@SynRegLab
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#SyntheticRegeneration & Systems Physiology Laboratory @Columbia | Engineering Tissue Healing through Systems Physiology
Manhattan, NY
Joined April 2022
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Check out our latest study on wound healing!
#SyntheticRegeneration
To regenerate organs, we must 1st decode how they heal. Mammals have repaired tissues for millions of years, yet the instruction manual for organ-scale coordination remained a mystery.
📢We constructed OWHA, a 4D multimodal healing atlas to study this!📢
#SyntheticRegeneration
Synthetic Regeneration Laboratory at Columbia retweeted
Macrophages eating living cells...NATURE paper !
nature.com/articles/s41586-0…
Synthetic Regeneration Laboratory at Columbia retweeted
Strongest Nature paper for us who love #cancer #immunology
Tumors use nerves to tell the brain to suppress immune response to all the cancer to grow.
nature.com/articles/s41586-0…
Nature research paper: Imaging cellular activity across all organs reveals body-wide circuits
go.nature.com/4xSOOsS
Synthetic Regeneration Laboratory at Columbia retweeted
Our September issue is live! 🎉
nature.com/nmeth/volumes/23/…
This special issue includes a Focus on AI in biological research. AI is everywhere these days, and is impacting nearly all fields of biology. To learn more, read our Editorial and check out the focus content!
Synthetic Regeneration Laboratory at Columbia retweeted
It was such a joy and privilege to host @andrewlji to kick off our @ColumbiaMed Dermatology Research Symposium Series! Work that sets a new standard for spatially-informed human skin biology!
Synthetic Regeneration Laboratory at Columbia retweeted
Excited to share our new review in @CellCellPress. We propose fibrosis is a reversible state encoded in chromatin circuits shaped by immune-stromal crosstalk, and that rewiring this logic may offer durable therapeutic paths. @GladstoneInst
authors.elsevier.com/sd/arti…
Synthetic Regeneration Laboratory at Columbia retweeted
Together with Emma Dann, we are thrilled to present a massive new Perturb-seq atlas of 22M primary CD4+ T cells, from 4 donors, across 3 timepoints – the result of a decade-long collaboration between the Marson (@MarsonLab) and Pritchard (@jkpritch) labs.
🧵👇
Synthetic Regeneration Laboratory at Columbia retweeted
Excited to share a public beta of Seurat 5.6, implementing major improvements for speed/memory/scalability of the core workflow, especially for large datasets.
Try it out! Installation instructions at: github.com/satijalab/seurat/…
Synthetic Regeneration Laboratory at Columbia retweeted
@biorxivpreprint A Cytokine Receptor Signaling Atlas Reveals How STAT Mosaics Fine-Tune T Cell Function
biorxiv.org/content/10.64898… @Stanford
Synthetic Regeneration Laboratory at Columbia retweeted
Excited to return to beautiful Barcelona to present our latest work on organ-scale wound regeneration! Equally thrilled at the opportunity to co-lead the New Technologies session! #SyntheticRegeneration
grc.org/epithelial-stem-cell…
Synthetic Regeneration Laboratory at Columbia retweeted
谁再说生物医学找插图难，我跟谁急——美国国家过敏与传染病研究所亲自下场，甩出了NIH官方背书的 BioArt Source ，一个完全免费、纯净无广的素材宝库！
三大硬核亮点：
1️⃣ 2000多张专业插画师出品的矢量图、图标、笔刷，品质全程在线
2️⃣ 病毒、细胞、解剖、免疫、蛋白质，生物医学主题几乎全覆盖
3️⃣ 公有领域版权，论文、教学、商业用途统统无压力
🔗 bioart.niaid.nih.gov
Synthetic Regeneration Laboratory at Columbia retweeted
Skin is the largest organ in the human body, and a major site of immune surveillance, aging, and disease. Developing scalable and data-driven methods for drug screening in complex human skin tissues will be critical for drug discovery in inflammation, tissue repair, cancer response, and many other aspects of disease-relevant skin biology.
Wonderful to work with Michael, @ladygaga, and the entire @OuterBio team! @Wing_VC
Meet @outerbio and YUNA. We are building the future of skin health. outerbio.com
Welcome from Michael, Me and the entire team at Outer Bio.
Brainstorming, engineering, and bonding! Our lab summer research retreat was an absolute blast 💡✨! Energized and ready to push the boundaries of synthetic regeneration!
Synthetic Regeneration Laboratory at Columbia retweeted
Breakthrough Nature paper...
Brain neurons record autoimmune activity and remember it....
nature.com/articles/s41467-0…
Synthetic Regeneration Laboratory at Columbia retweeted
Drs. David Kaplan (@TuftsUniversity) and Gordana Vunjak-Novakovic (@GVNlab) have defined the hallmarks of #fibrosis across organ systems to establish foundational design criteria necessary for modelling human fibrosis in vitro.
Abstract: go.nature.com/45uJv6p
We are proud to release the world's first virtual cell -- a multi-modal, multi-scale, dynamic, and stateful world model of the cell, the first step toward an AI-driven Digital Organism (AIDO).
Synthetic Regeneration Laboratory at Columbia retweeted
This study established a high-fidelity mouse #SkinOrganoid platform to simulate clinically relevant stressors and identify the core regulatory components of the regenerative program. 🧫
#Fibroblast #OpenAccess
💡 Learn more: bit.ly/4g5UYOH
The biggest bottleneck in high-res #SpatialTranscriptomics? Accurate cell segmentation in dense tissues. 🧬
Meet DISSECT: a new model published in @NatComputSci that integrates cytological images with spatial transcriptomic profiles to solve this. 🧵👇
ALT Figure illustrating the DISSECT architecture. It extracts multiscale image features via an encoder, detects bounding boxes using a diffusion model, and refines final single-cell segmentation masks using transcriptome-guided gradient fields.