Postdoc @durocherlab. Interested in genome stability, DNA repair
Toronto, Ontario
Joined May 2020
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Sumin Feng retweeted
A high-resolution view of how replication-coupled DNA breaks are generated, processed and repaired. Congrats to @pavani_raphael, @TripathiVeenu, and many terrific collaborators including @FrogWalterLab, @CejkaLab, @weiwsmiling. See science.org/doi/epdf/10.1126…
Sumin Feng retweeted
We're excited to report a new mechanism of replisome proteostasis cell.com/cell/fulltext/S0092…. 55LCC ATPase/unfoldase complex dependent replisome turnover prevents chromosome instability. Great collaboration by @vidhya_k7 and @RobertLDilley with @FoglizzoMartina and @zeqiraj.
Sumin Feng retweeted
Very excited to share a new preprint from the @durocherlab! We used AlphaFold2 to exhaustively map the 53BP1-RIF1-shieldin-CST pathway and found a novel RIF1-SHLD3 binding interface essential for pathway function. 🧵below 1/6
biorxiv.org/content/10.1101/…
Sumin Feng retweeted
🚨Job alert🚨 Our lab is looking for a bioinformatics associate to support our work using functional genomic/proteomic approaches (CRISPR screens, proximity proteomics, various Seq approaches).
👇
contact2.mshri.on.ca/hr/DEFA…
Thanks Dongyi and collaboraters!
Our final version came out with new data. Happy to share our study linking DNA repair and dynamic changes of high-order chromatin structure to suppress initiation of resection. Thanks to Sumin Feng, Sai Ma & Kejiao Li in my lab and our collaborators!
disq.us/t/45afp7h
Sumin Feng retweeted
Honored and looking forward to presenting my postdoctoral work on the 53BP1-RIF1-shieldin pathway as part of the ECS3 seminar at @ircm_mtl!
Don't miss our first ECS3 Seminar next week: a groundbreaking initiative whose mission is to showcase early career scientists and a great opportunity to discover the exciting projects of researchers in training ircm.qc.ca/en/events-details… #DrivenByLife
Sumin Feng retweeted
Happy to share our new work that RIF1 forms a complex with histone chaperone ASF1, which condenses adjacent chromatin by heterochromatinization to protect broken DNA ends and promote NHEJ. biorxiv.org/content/10.1101/…
Sumin Feng retweeted
We found that the Fanconi anemia pathway is intrinsically a BIR pathway and persistent replication stress is a potential offending cause of disease symptoms in Fanconi anemia. nature.com/articles/s41594-0…