@SuLabUCSD

Sensory neurobiologist at the University of California San Diego

 San Diego
sulab.biology.ucsd.edu
Joined February 2019
  • Tweets260
  • Following321
  • Followers492
7Media
More with less: @UCSanDiego scientists in @ucsdbiosciences and @UCSDPhySci have proposed a solution for how flies use a simple but efficient method to recognize odors. The answer lies at the edges of their sensory systems. today.ucsd.edu/story/detecti… @yahdef @SuLabUCSD @PuriPalka

Detecting Odors on the Edge: Researchers Decipher How Insects Smell More with Less

While humans feature a sophisticated sense of smell, insects have a much more basic olfactory system. Yet they depend upon smell to survive. Scientists have figured out how fruit flies use a simple...

today.ucsd.edu
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Richard Benton@bentonlab9 Aug 2023
#PLOSBiology: Functional unknomics: Systematic screening of conserved genes of unknown function dx.plos.org/10.1371/journal.…
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Yonatan Aljadeff@yahdef27 Jul 2023
The array of olfactory receptor neurons in flies is highly structured. Our collaborator Chih-Ying Su @SuLabUCSD showed previously that receptors are electrically coupled, a coupling that affects animal behavior. nature.com/articles/nature11… 2/

Non-synaptic inhibition between grouped neurons in an olfactory circuit

Nature - It has been suggested that the electrical activity of one neuron can influence that of its unlinked neighbour, but this so-called ephaptic effect is widely assumed to be weak and has been...

nature.com
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New paper using reconstructions from NeuroMorpho.Org: arxiv.org/abs/2307.01499
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Greg Jefferis@gsxej30 Jun 2023
Building the FlyWire #connectome from the FAFB brain was a massive team effort. But neuroscientists need to find their favourite neurons in this huge dataset. We report an indexed parts list, systematically annotating all 127k neurons (Schlegel et al biorxiv.org/content/10.1101/…) 1/7

A consensus cell type atlas from multiple connectomes reveals principles of circuit stereotypy and...

The fruit fly Drosophila melanogaster combines surprisingly sophisticated behaviour with a highly tractable nervous system. A large part of the fly’s success as a model organism in modern neuroscie...

biorxiv.org
Sven Dorkenwald@sdorkenw30 Jun 2023
We are releasing a whole-brain connectome of the fruit fly, including ~130k annotated neurons and tens of millions of typed synapses! Explore the connectome: codex.flywire.ai/ Reconstruction paper: biorxiv.org/content/10.1101/… Annotation paper: biorxiv.org/content/10.1101/… 1/6
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Richard Benton@bentonlab6 Jul 2023
New lab pre-print from @MShahand and co. Evolution of circadian behavioral plasticity through cis-regulatory divergence of a neuropeptide gene biorxiv.org/content/10.1101/…

Evolution of circadian behavioral plasticity through cis-regulatory divergence of a neuropeptide...

Widely-distributed species experience substantial environmental variation, which they often accommodate through behavioral plasticity. Although this ability is integral to fitness, we have little...

biorxiv.org
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Today the lab was greeted by innocuous appearing white adapters plugged in lab bays and offices. We inquired and learned the university is monitoring 'occupancy', i.e. when we are/are not in. Be on the lookout! Big brother is watching!👀
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Yonatan Aljadeff@yahdef19 May 2023
Congratulations to Palka @PuriPalka for receiving the @UCSanDiego GPSA Interdisciplinary Research Award! Pictured with Palka are Chih-Ying @SuLabUCSD and I looking and feeling very proud.
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applications are due TOMORROW! MARCH 15TH! come spend the summer at cshl and learn everything about drosophila neurobiology! we've got an aamzing slate planned with a cavalcade of star faculty! don't miss out. RT and DM me with any q's! meetings.cshl.edu/courses.as…

Drosophila Neurobiology: Genes, Circuits & Behavior

Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.

meetings.cshl.edu
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Richard Benton@bentonlab6 Mar 2023
Remarkable! Ricca’s factors as mobile proteinaceous effectors of electrical signaling cell.com/cell/fulltext/S0092…

Ricca’s factors as mobile proteinaceous effectors of electrical signaling

β-THIOGLUCOSIDE GLUCOHYDROLASE 1 and 2 as xylem-mobile factors to generate membrane depolarizing elicitors in the veins of wounded Arabidopsis, highlighting a mechanism for inter-organ electrical...

cell.com
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Meg Younger@meg_younger16 Dec 2022
Richard Benton@bentonlab15 Dec 2022
New preprint: thanks to #AlphaFold and @natehimmel, we discover potential HUMAN homologues of insect Odorant Receptors, and bunch of cryptic Gustatory Receptor-like proteins ... biorxiv.org/content/10.1101/…

Structural screens identify candidate human homologs of insect chemoreceptors and cryptic Drosoph...

Insect Odorant receptors and Gustatory receptors define a superfamily of seven-transmembrane domain ligand-gated ion channels (termed here 7TMICs), with homologs identified across Animalia except...

biorxiv.org
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Matthieu Louis@tamsioul16 Dec 2022
[1/11] @DavidTadres and I are excited to share new research doi.org/10.1126/sciadv.ade72… where we show that olfactory sensory neurons undergo silencing due to depolarization block at ethologically relevant odor concentrations. #olfaction #chemosensation #behavior

Depolarization block in olfactory sensory neurons expands the dimensionality of odor encoding

Silencing olfactory sensory neurons through depolarization block shapes the peripheral representation of odors.

science.org
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NYT Science
@NYTScience8 Oct 2022
Two mosquito species in their larval stage catch prey by shooting their heads away from their bodies like harpoons, mouths open, and reeling in their victims with a thin neck membrane nyti.ms/3ypfmVT

‘Our Jaws Dropped’: Mosquito Larvae’s Killer Harpoon Heads Revealed. (Published 2022)

A new study shows mosquito larvae feeding in slow motion, under a microscope, for the first time.

nytimes.com
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BMC Biology@BMCBiology11 Oct 2022
New #openaccess research from Richard Benton @bentonlab and co. characterizing #Drosophila #olfactory subsystems identifies a new protein - Osiris 8 - required for #insect #pheromone detection. bit.ly/3SVhL2E #odorant #scRNAseq #RNAseq #transcriptomics
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We're hiring! (and we have interesting windows) Come join us! Tenure track assistant professor in Neurobiology, open to all kinds of applicants 🪰🕊️🦋🐁🐭🤸‍♂️🪱🐒🐟🦐🦜🐞🦉🐦 @NUneurobio neurobiology.northwestern.ed…
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i still don't believe something until i can hold it in my hand (i'm a deeply distrusting individual). but our issue of @Dev_Cell with @lucas__restrepo's gamma secretase paper is finally here! hard copies! it's so pretty and i'm so proud of the authors and the artist @GAL4science!
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Happy to share our newest work that is published online in @NeuroCellPress today! cell.com/neuron/fulltext/S08… Great teamwork by @JungWooYang2 , Pablo Serrano, and @Xuming_Yin during the tough covid time. Also thanks to @Xiaochen_Sun_ and Yingxi Lin for sharing the NRAM virus with us!

Functionally distinct NPAS4-expressing somatostatin interneuron ensembles critical for motor skill...

Utilizing in vivo two-photon imaging in behaving mice, Yang et al. reveal that motor learning triggers an emergence of an NPAS4-expressing SST-IN ensemble that regulates the spine remodeling of...

cell.com
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It is generally accepted that fat tissues “talk” to the brain via secreted hormones. Our amazing student @yuwang, co-mentored by @liye_tsri, discovered that somatosensory neurons innervating adipose tissue act as a break to counteract sympathetic activity. nature.com/articles/s41586-0…
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PhD Fellowships opportunities at the University of Lausanne (including in my lab): unil.ch/ecoledoctoralefbm/en… via @unil
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Paul Garrity@Nemvec29 Aug 2022
Mapping OR ligand specificity determinants from Leal lab: Two mosquito odorant receptors with reciprocal specificity mediated by a single amino acid residue | bioRxiv biorxiv.org/content/10.1101/…

Two mosquito odorant receptors with reciprocal specificity mediated by a single amino acid residue

The southern house mosquito, Culex quinquefasciatus , utilizes two odorant receptors, CquiOR10 and CquiOR2, narrowly tuned to oviposition attractants and well conserved among mosquito species. They...

biorxiv.org
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