@StottmannLab

PI of lab with long-term goals to understand the genes and mechanisms guiding brain and face developmental biology. Tweets and opinions are my own.

 Nationwide Children's Hospital
nationwidechildrens.org/find-a-doctor/profiles/rolf-w-stottmann
Joined March 2014
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  • Followers305
103Media
We’re recruiting a postdoc to follow up on an astonishing number of mutants with craniofacial phenotypes from our ENU mutagenesis screen. Great opportunity for someone interested in developmental genetics, craniofacial biology, mouse genetics & gene discovery. Please share!
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We have parallel efforts focused on forebrain development and cortical circuits. Happy to share more.
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Rolf_Stottmann retweeted
Itai Yanai
@ItaiYanaiJun 24
🔥 Published today, and just in time for summer conferences, here are your guidelines for presenting badly
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Always a pleasure to participate for a couple of days in the legendary Cold Spring Harbor "Mouse Course." Thanks to Matt A, Katie F, Danelle D and Loydie J-M for the invite. Hope to do it again. Best of luck to the great young scholars i met this week.
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New paper in @iScience_CP! We show that Piga is essential for forebrain, oligodendrocyte, and cerebellar development, while Pgap2 is surprisingly dispensable in these contexts.
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A striking difference for two genes in the same GPI-anchor biosynthesis pathway. Congrats Jennifer Watts and Jesus Leal! #Neuroscience #Genetics
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Excited and grateful for a new NIH NOA for a 5-year project. 🎉 A reminder that persistence is key A0 (7/2023): 27% A1 (3/2024): ND 😬 A0 (10/2024): 22% A1 (7/2025): 2% NOA (5/2026) 1,033 days from first submission to funding. If you believe in the idea, keep going.
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Grateful to Andrea Miller, Ivan Martinez Duncker and the CDG CARE team for a fantastic 2026 Scientific & Family Weekend in Orlando. Inspiring to connect with clinicians and PIGA families -- real momentum behind gene replacement therapy for PIGA and other CDGs.
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Save the Date! The 14th Structural Birth Defects Meeting will be held September 21-23 @ChildrensPhila Keynote Speakers: Erica E. Davis at @LurieChildrens @NUFeinbergMed & Jeremy Reiter @ReiterLab @UCSF. Abstracts & registration open May 1. #14thSBD #structuralbirthdefects
14th Structural Birth Defects Meeting flyer Children's Hospital of Philadelphia; Philadelphia | September 21-23 2026; Abstract Deadline June 22; Photo of Children's Hospital of Philadelphia; Abstracts & Registration Open May 1; Keynote Speakers: Erica E. Davis, PhD, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University; Jeremy Reiter, MD, PhD, University of California, San Francisco

ALT 14th Structural Birth Defects Meeting flyer Children's Hospital of Philadelphia; Philadelphia | September 21-23 2026; Abstract Deadline June 22; Photo of Children's Hospital of Philadelphia; Abstracts & Registration Open May 1; Keynote Speakers: Erica E. Davis, PhD, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University; Jeremy Reiter, MD, PhD, University of California, San Francisco

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Heading to my first CDG (Congenital Disorders of Glycosylation) Scientific & Family Conference this week in Orlando (CDG-CARE). Looking forward to reconnecting with colleagues and sharing our latest work on Piga gene replacement therapy—led by @jennwatts11 .
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We do some cool stuff in the @StottmannLab! instagram.com/p/DGi6yh8JiPl/…
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#Neurofilament #Confocal #mouseembryo #Stottmann_lab
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As part of a larger effort to sequence patients with micrognathia and cleft palate, Andrew M. Vontell et al. identified candidate pathogenic variants in dmx-like 1 (DMXL1). Read the open access article in Differentiation to learn more: doi.org/10.1016/j.diff.2025.… @Paul_Iyyanar
Fig. 5. Dmxl1 embryos show no signs of craniofacial dysmorphism or micrognathia. (A–H) Skeletal preparations to highlight craniofacial structures (A–D) and dissociated mandibles at E18.5 (E–H).

ALT Fig. 5. Dmxl1 embryos show no signs of craniofacial dysmorphism or micrognathia. (A–H) Skeletal preparations to highlight craniofacial structures (A–D) and dissociated mandibles at E18.5 (E–H).

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Rolf_Stottmann retweeted
craniofacialgenetics@SCGDB1Feb 16
We are excited to announce that the 49th Annual Meeting of the SCGDB will be held September 28th-30th, 2026 in Seattle! The meeting will be hosted by the University of Washington @UW
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Rolf_Stottmann retweeted
Paul P. R. Iyyanar@Paul_IyyanarJan 4
Happy to share my first paper from the @StottmannLab, on Cse1l neural crest function just got accepted for publication in @Dev_Bio_Journal sciencedirect.com/science/ar…
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Rolf_Stottmann retweeted
DMM Journal@DMM_JournalFeb 23
Rebekah Niewoehner, @StottmannLab & co showed that mutations in Ttc21b contribute to human primary #microcephaly, and that the severe microcephaly in homozygous #mouse mutants arises from impaired neural progenitor proliferation and differentiation. Read doi.org/10.1242/dmm.052392
The figure shows staining of mouse embryos with X-gal to highlight Ttc21b in whole-mount embryos (panels A-D,H) or after sectioning (panels E-G,I-N). Boxed areas in panel E are shown magnified in panels F and G, boxed areas in panels I and L are shown magnified in panels J and M. Arrows indicate specific areas of lacZ expression.

ALT The figure shows staining of mouse embryos with X-gal to highlight Ttc21b in whole-mount embryos (panels A-D,H) or after sectioning (panels E-G,I-N). Boxed areas in panel E are shown magnified in panels F and G, boxed areas in panels I and L are shown magnified in panels J and M. Arrows indicate specific areas of lacZ expression.

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yeah, this is just not what it used to be. will leave the account up for now but going looking for some blue skies (from now on???)
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OBX 2025 - booked. if you know, you know
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saw my first Christmas TV commercial last night........
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