@StevenJulious

Professor of Medical Statistics at The University of Sheffield. Statistician, walker and Garibaldi Red. The opinions are personal

 Sheffield
sheffield.ac.uk/scharr/sections/dts/statistics/staff/sajulious
Joined October 2019
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  • Followers874
208Media
Have just received the authors copy the 2nd edition of my book. Sample Sizes for Clinical Trials It is due out 21 June #statstwitter #epitwitter #ClinicalTrials #clinicalresearch @ScHARRSheffield @ScHARR_DTS @CTRU_Sheffield
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Had a paper published with @Flight_LG and @Alan_Brennan entitled Value-adaptive clinical trial designs for efficient delivery of publicly funded trials - a discussion of methods, case studies, opportunities and challenges doi.org/10.1186/s12874-025-0…

Value-adaptive clinical trial designs for efficient delivery of publicly funded trials - a discus...

BMC Medical Research Methodology - Value-adaptive designs for clinical trials are a novel set of emerging methods for delivering greater value for clinical research. There is increasing interest in...

link.springer.com
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The protocol for MissionEB - a randomised, double-blinded, placebo-controlled, two-centre, crossover trial - a study to assess mesenchymal intravenous stromal cell infusions in children with recessive dystrophic epidermolysis bullosa has been published doi.org/10.1136/bmjopen-2024…
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A great talk by @JamesSalsbury at #sct2025 entitled Assurance methods for designing a survival trial with delayed treatment effects
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Attending an excellent talk by @NikkiTotton entitled at #SCT2025 entitled Using benefit risk methods to adjust the non-inferiority margin based on treatment benefits
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Had a paper published with Kelly Grant on the analysis of recurrent events in clinical trials doi.org/10.1177/096228022513…

Analysis of recurrent events in cluster randomised trials: The PLEASANT trial case study - Kelly...

Recurrent events for many clinical conditions, such as asthma, can indicate poor health outcomes. Recurrent events data are often analysed using statistical met...

journals.sagepub.com
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We recommend that the conditional frailty model be used for these data in trials, including cluster randomised trials, to help to explain changes in event risk over time and assist clinical interpretation
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In clinical trials it is not only potential benefits that should be measured - it is crucially important that any potential #harms are also investigated 1/7 #MethodologyMonday #118
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Steven Julious retweeted
StatsCI@stats_ci13 May 2025
New Publication 🔊: Trials special series - the collection, analysis and reporting of adverse events in randomised controlled trials by @RachPips & @VR_Cornelius trialsjournal.biomedcentral.…

Trials special series - the collection, analysis and reporting of adverse events in randomised...

Trials -

link.springer.com
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Today's date 5-2-25 Is a palindrome
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My PhD student is undertaking a DELPHI on reporting of sample sizes with studies with adaptive designs in protocols and grants. Please fill in if you can
qiang zhang@qiangzh837696925 Feb 2025
Replying to @qiangzh83769692
This sub-study is part of a PhD project at the University of Sheffield, supervised by Prof. Steven Julious (@StevenJulious ) and Dr. Munya Dimairo (@mdimairo ) Please feel free to reach out to our team. Email: [email protected] #AdaptiveTrials #TrialDesign #SampleSize
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Just had a paper published led by @HollyTibble with researchers from @AUKCAR on using routine data in research
Holly Tibble@HollyTibble13 Jan 2025
New Paper! Routinely recorded primary care data can be used to evaluate interventions provided within routine care, anecdotally researchers in the @AUKCAR have encountered multiple barriers to access and use. informatics.bmj.com/content/…
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My paper with Amy Whitehead Mike Campbell & Cindy Cooper Estimating the sample size for a pilot randomised trial to minimise the overall trial sample size for the external pilot and main trial for a continuous outcome variable Has been cited 1000 times doi.org/10.1177/096228021558…
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Just had a paper published entitled "A review of UK publicly funded non-inferiority trials: is the design more inferior than it should be?" Led by Nikki Totton with Stephen Walters and Elizabeth Coates doi.org/10.1186/s13063-024-0…
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The paper found the use of term "non-inferioroity" increased with the publication of the CONSORT Non-inferiority Guidelines
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Nearly half of studies did not justify their non-inferiority limit
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Justed had paper published with @qiangzh83769692 , @mdimairo , Jen Lewis and Zihang Yu entitled "Reporting and communication of sample size calculations in adaptive clinical trials: a review of trial protocols and grant applications" doi.org/10.1186/s12874-024-0…
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For industry studies 68% have just one interim analysis compared to 51% for publicly funded
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The timing of the first inteim analysis between industry and publicly funded trials is quite marked. For industry studies the first interim is after 50% of the information fration. By comparison for publicly funded trials the timing is bi-modal
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For industry studies 68% have just one interim analysis compared to 51% for publicly funded
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The timing of the first inteim analysis between industry and publicly funded trials is quite marked. For industry studies the first interim is after 50% of the information fration. By comparison for publicly funded trials the timing is bi-modal
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