@stats_ci

All about Statistical Methods in Clinical Trials and Good Statistical Practice in Healthcare Research. @ImperialCTU, Imperial College London #StatsCI

 London, UK
statsci.co.uk/
Joined August 2019
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StatsCI retweeted
Suzie Cro@Suzie_croApr 29
How can Bayesian methods help us learn more from Studies Within A Trial (SWATs)? Find out here where we explore how Bayesian methods and ACCEPT analysis help us get more meaningful insights from SWATs: link.springer.com/article/10… #Trials #TrialMethodology #SWAT #BayesianStatistics

The use of Bayesian methods for the analysis of Studies Within A Trial: a proof-of-concept case...

Trials - A Study Within A Trial (SWAT) is a research study embedded within a larger trial which aims to investigate different strategies for a particular trial process, such as trial recruitment....

link.springer.com
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📣New Publication: Investigating estimand considerations in adaptive trials: a systematic review link.springer.com/article/10…

Investigating estimand considerations in adaptive trials: a systematic review

Trials - Randomised controlled trials (RCTs) are the gold standard for evaluating treatment effects, with the results informing policy and clinical practice. To ensure appropriate methods are...

link.springer.com
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In 2024 we hosted Hannah Wallace and Fran Piazza as part of the NIHR Undergraduate Internship Programme and NIHR RSS Imperial College London & Partners Hub - this review summarises the findings from their research project!
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It provides evidence that there is still a lack of uptake of the estimand framework in RCTs & how clear guidance on how to implement the estimand framework to trials with an adaptive design is needed
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📚 All I want for Christmas…is a precisely defined research question link.springer.com/article/10…

All I want for Christmas…is a precisely defined research question

Trials -

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Last week we enjoyed Victoria Cornelius's Inaugural lecture! Under pressure: smarter trials for better health outcomes - covering traditional trials to Bayesian, adaptive, and decentralised approaches. If you missed it - you can watch the recording here: youtube.com/watch?v=DpejpM6e…
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📢 New publication in #Trials led by @Suzie_cro with the HEALTHY STATS public involvement group: Supporting public involvement in defining estimands: a practical tool accessibly explaining the five key attributes of an estimand trialsjournal.biomedcentral.…

Supporting public involvement in defining estimands: a practical tool accessibly explaining the...

Trials - An estimand is a precise description of the treatment effect a trial is aiming to find out. We previously identified that public partners (defined as patients and/or members of the public...

link.springer.com
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📢 New blog post: statsci.co.uk/post/highlight… One of our NIHR pre-doctoral fellows Xiao Xuan Tan recently attended ISCB 2025 which was packed with cutting-edge statistical research & inspiring keynotes. Read all about her key highlights & takeaways from attending the conference

Highlights and Reflections from ISCB 2025

This summer, I had the opportunity to attend the 46th Annual Conference of the International Society for Clinical Biostatistics (ISCB) in Basel. It was an incredible week of learning and networking...

statsci.co.uk
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Our Research Methods Academy Seminar Series: 2nd trials seminar  Prof. Karla Hemming will be discussing the updated guidelines for Statistical Analysis Plans in Cluster Randomised Trials, ensuring transparency & credibility in trial design Register: imperial-ac-uk.zoom.us/webin…
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New publication 📢: A Bayesian framework to evaluate non-inferiority in randomised controlled trials of uncommon conditions - Journal of Clinical Epidemiology led by Victoria Cornelius jclinepi.com/article/S0895-4…

A Bayesian framework to evaluate non-inferiority in randomized controlled trials of uncommon...

Noninferiority (NI) trials typically require larger sample sizes than superiority comparisons. This is problematic for uncommon conditions where recruitment is restricted. When a power calculation...

jclinepi.com
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📢 Chelsea&Westminster NHS Trust Research Dept. are looking for an enthusiastic & dedicated senior statistician with experience working on drug trials to lead on the statistical work for a small portfolio of sponsored studies. For details please see here: chelwest.nhs.uk/about-us/wor…

Work with us

chelwest.nhs.uk
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💬Got 5 mins? Help improve clinical trials by sharing your thoughts on health data collection. Annie Wright a PhD researcher at Imperial has designed this survey with the help of her public involvement groups. imperial.eu.qualtrics.com/jf…... #PPI #HealthEquity #ResearchVoices
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New publication 📣: Are estimands being correctly used? A review of UK research protocols by Timothy P. Clark, Richard H. Wicentowski, Suzie Cro, Matthew R. Sydes & Brennan C. Kahan trialsjournal.biomedcentral.…

Are estimands being correctly used? A review of UK research protocols

Trials - The use of estimands in clinical trials was formalised with the adoption of the final International Conference on Harmonisation E9 Addendum on Estimands and Sensitivity Analysis in...

link.springer.com
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🎉 Excited to welcome two NIHR Pre-Doc Fellows! Hannah Wallace from Scotland who will work with @RachPips & @Suzie_cro. And, Oluwaseun Olayiwola from Nigeria who will work with @LeilaJTF , @Suzie_cro and @DrKGibbons .
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Attending the International Society for Clinical Biostatistics this week? @ISCB_info Don’t miss @ellievanvogt and Xiao Xuan who will be presenting these exciting topics:
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Meet Alex Dixon, who is spending his summer experiencing life within ICTUs statistics and trial methodology group and conducting a research project with us as part of an NIHR undergraduate internship Find out what he has been up to here: statsci.co.uk/news
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🔊We're hiring! Imperial Clinical Trials Unit are looking for an ambitious senior statistician with experience in clinical trials including adaptive trials, to lead a research programme in antimicrobial resistance & data-enabled trials. Full details: imperial.ac.uk/jobs/search-j…

Description

Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...

imperial.ac.uk
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Delighted to share registration is open for Professor Victoria Cornelius's inaugural lecture -Under pressure: smarter trials for better health outcomes- Thursday, 30 October 2025, 17.30-18.30, Imperial College South Kensington. For details & registration: imperial.ac.uk/events/196880…
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New publication📣- Incorporation of Patient & Public Involvement in Statistical Methodology Research: Summary of Workshop Proceedings -aimed at addressing barriers to meaningful PPI in statistical methodology research. Open access in Statistics in Medicine onlinelibrary.wiley.com/doi/…
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Attending NIHR stats conference this week @NIHRStatistics ? Don’t miss @Annie_Stats , @LeilaJTF , @JakElkes , @marie_miller_ , and Francesco Lala, who will be presenting these exciting topics:
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