@mdimairo

Senior Research Fellow. Statistician. Novel trial methods. Former Wellcome Trust & NIHR DR fellow. Views are my own. RT≠ENDORSEMENT 🇿🇼 🇬🇧

 Sheffield, England
orcid.org/0000-0002-9311-6920
Joined July 2010
  • Tweets38.1K
  • Following2.3K
  • Followers2.5K
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Canner (1983) ... “decision-making in clinical trials is complicated & often protracted... no single statistical decision rule or procedure can take the place of well-reasoned consideration of all aspects of the data by a group of concerned, competent, & experienced persons...”
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We applaud the UK’s MHRA for implementing these long-overdue measures to inform patients of the risks of suicidality when initiating antidepressant treatment or adjusting dosages, as well as the risk of persistent sexual dysfunction. We urge the U.S. @FDA to follow suit and, alongside other @HHSGov agencies, prioritize helping those who have already been harm. Years-long sufferers of PSSD @PSSDNetwork and protracted withdrawal deserve acknowledgment, answers, and, most importantly, effective treatments.
MHRAgovuk
@MHRAgovukOct 15
The MHRA is introducing a series of new measures to strengthen how risks associated with antidepressant medicines are communicated to patients, carers and healthcare professionals. Read the full drug safety update here: brnw.ch/21x6qlr
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Munya Dimairo retweeted
Yonemoto N@nyonenyoneOct 15
Using Individualized Treatment Effects to Assess Treatment Effect Heterogeneity - Sechidis - 2025 - Statistics in Medicine - Wiley Online Library onlinelibrary.wiley.com/doi/…

Using Individualized Treatment Effects to Assess Treatment Effect Heterogeneity

Assessing treatment effect heterogeneity (TEH) in clinical trials is crucial, as it provides insights into the variability of treatment responses among patients, influencing key decisions related to...

onlinelibrary.wiley.com
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Ever looked at your todo list and everything seems urgent and important, and get depressed?
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Munya Dimairo retweeted
MHRAgovuk
@MHRAgovukOct 14
The MHRA’s 2030 Strategy is about harnessing the best of scientific and technological innovation so patients across the UK can benefit from safe, effective treatments more quickly. Read the Executive Summary brnw.ch/21x6onP #innovation #lifesciences #patientsafety
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Munya Dimairo retweeted
MHRAgovuk
@MHRAgovukOct 15
The MHRA is introducing a series of new measures to strengthen how risks associated with antidepressant medicines are communicated to patients, carers and healthcare professionals. Read the full drug safety update here: brnw.ch/21x6qlr
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Munya Dimairo retweeted
Triad sou.@triadsouOct 15
Estimands for combination therapy oncology trials with competing risks and their integration with Project SignifiCanT. Ayon Mukherjee, Satrajit Roychoudhury, Atanu Bhattacharjee, James M. S. Wason. Journal of Biopharmaceutical Statistics. tandfonline.com/doi/full/10.…

Estimands for combination therapy oncology trials with competing risks and their integration with...

The evaluation of combination therapies in oncology increasingly demands estimand frameworks that reflect component-specific treatment strategies, complex intercurrent events (ICEs), and competing ...

tandfonline.com
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Munya Dimairo retweeted
Ash Paul
@pash22Oct 14
Many patient, consumer reps on @FDA advisory panels have ties to groups funded by pharma, @ProfGenKanter et al analysis finds: Findings highlight gap in conflict-of-interest policy that could be source of undue influence via @pharmalot statnews.com/pharmalot/2026/…

Many patient, consumer reps on FDA advisory panels have ties to groups funded by pharma, analysis...

Nearly 40% of FDA advisory committee meetings over a 20-year period included either a patient or consumer rep with active ties to an advocacy group funded by pharma companies.

statnews.com
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Munya Dimairo retweeted
Ash Paul
@pash22Oct 14
How should the results of Alz' disease treatment trials be communicated to colleagues, patients and families? alz-journals.onlinelibrary.w… via @ProfRobHoward
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Munya Dimairo retweeted
Ash Paul
@pash22Oct 12
Communicating Uncertainty and Influence on Treatment Decision-Making by Patients jamanetwork.com/journals/jam… via @AlexChaitoff et al
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Munya Dimairo retweeted
あさひな@aaiashnOct 12
Moving towards best practice when using inverse probability of treatment weighting (IPTW) using the propensity score to estimate causal treatment effects in observational studies - Austin - 2015 - Statistics in Medicine - Wiley Online Library onlinelibrary.wiley.com/doi/…

Moving towards best practice when using inverse probability of treatment weighting (IPTW) using the...

The propensity score is defined as a subject's probability of treatment selection, conditional on observed baseline covariates. Weighting subjects by the inverse probability of treatment received...

onlinelibrary.wiley.com
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Removing Trump will end this war!
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Volodymyr Zelenskyy is an exceptional leader of our time.
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Munya Dimairo retweeted
Donald Tusk
@donaldtuskOct 11
After my today’s talk with @ZelenskyyUa, I’m absolutely convinced that no-one and nothing can break Ukraine and its’ President in their fight against the Russian aggression. I have assured him that he can count on Poland’s and Europe’s full solidarity with the Ukrainian nation.
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Ukraine must hit more data centres!!
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Weird to find myself in agreement.
Laura Loomer
@LauraLoomerOct 11
The Ukrainian people are simply just trying to survive.
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Munya Dimairo retweeted
Triad sou.@triadsouOct 11
ROC curve analysis for functional markers. Ana M. Bianco, Graciela Boente, Juan Carlos Pardo-Fernández. Journal of Multivariate Analysis. sciencedirect.com/science/ar…
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In the last 2 decades we have provided over 23,000 career development awards across more than 200 different professions. Our investment in building clinical academic careers is creating the capacity and resilience to enable us to meet the health and social care challenges of the future, for the health and wealth of the nation. Find out more about how we are building the foundations for research in the latest in our Gamechanger series at lnkd.in/4G0r4+ #NIHR20
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Apply now to be a mentee on the NIHR Mentoring Programme! If you are an early to mid-career researcher, a mentor could help you to: ⭐ build confidence in your publications and funding applications ⭐ expand your network and connect strategically with senior professionals ⭐ solve challenges and learn to navigate the complexities of academic life Apply before 15 October ➡️nihr.ac.uk/funding/mentoring…
"My mentor offered a highly effective sounding board to consider my career options and to make informed decisions." Dr Kaat De Backer, Postdoctoral midwife research fellow

ALT "My mentor offered a highly effective sounding board to consider my career options and to make informed decisions." Dr Kaat De Backer, Postdoctoral midwife research fellow

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