@StephenWalsh4

Associate Principal Scientist at Bicycle Therapeutics. Former PhD and PDRA in Spring lab (Chemistry) and Carroll lab (CRUK CI) at University of Cambridge

 Cambridge, England
Joined February 2012
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  • Following491
  • Followers170
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📢 Exciting Postdoctoral Research Associate opportunity for a chemist with research experience in organic synthesis and/or chemical biology is now available in our group. For more info check jobs.cam.ac.uk/job/37525/ 📢
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'Antibody dual-functionalisation enabled through a modular divinylpyrimidine disulfide rebridging strategy' by David R. Spring & Abigail R. Hanby et al @SpringGroupChem @ChemCambridge #OpenAccess 🔓 rsc.li/3BYcJgb
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Happy to share our newly accepted manuscript in @ChemCommun: "Antibody dual-functionalisation enabled through a modular divinylpyrimidine disulfide rebridging strategy" doi.org/10.1039/D2CC02515A pubs.rsc.org/en/content/arti…

Antibody dual-functionalisation enabled through a modular divinylpyrimidine disulfide rebridging...

Herein we report the development of a methodology for the dual-functionalisation of IgG antibodies. This is accomplished through the combination of disulfi

pubs.rsc.org
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We're delighted to share our most recent work in antibody conjugation, featuring all-in-one disulfide bridging using TetraDVP reagents. Now in @ChemicalScience, check it out! doi.org/10.1039/d2sc02198f @ChemCambridge
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New 🔥 article from Ian Paterson, @nelsonyslam and first author Tegan Stockdale at @chemcambridge 🔓 'A synthesis-enabled relative configurational assignment of the C31–C46 region of hemicalide' rsc.li/3vWFG8Z

A synthesis-enabled relative configurational assignment of the C31–C46 region of hemicalide†

With 21 unknown stereocentres embedded in spatially separated stereoclusters, the cytotoxic polyketide hemicalide represents a seemingly intractible struct

pubs.rsc.org
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David Spring at @ChemCambridge, Jason Carroll at @CRUK_CI and colleagues use divinylpyrimidine reagents for the synthesis of antibody–drug conjugates. @springgroupchem rsc.li/3sR6Tr4

Divinylpyrimidine reagents generate antibody–drug conjugates with excellent in vivo efficacy and...

The development of divinylpyrimidine (DVP) reagents for the synthesis of antibody–drug conjugates (ADCs) with in vivo efficacy and tolerability is reported

pubs.rsc.org
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A funded PhD position is available for those interested in organometallic, organic synthesis, radical chemistry and catalysis @TheKumarLab1 @UCLChemistry RTs greatly appreciated. PhD opportunity on @FindAPhD: findaphd.com/phds/projectdet…

A three-year PhD studentship in organic synthesis for the development of sustainable C–O bond...

PhD Project - A three-year PhD studentship in organic synthesis for the development of sustainable C–O bond activation technologies at University College London, listed on FindAPhD.com

findaphd.com
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Are you passionate about microbiology and chemistry? @EachanJohnson and I have the perfect PhD project for you! Join us @TheCrick to work on TB drug discovery. RT highly appreciated! #chemtwitter #ukchemjobs #chemjobs crick.ac.uk/careers-study/st…
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If you are interested in doing a PhD in organic synthesis and photochemistry have a think about this opportunity in @NappiGroup! Deadline: August 15th! RT much appreciated thanks!
CiQUS
@ciqususc28 Jul 2021
📢 #CiQUS researcher Dr. Manuel Nappi (@ManuelNappi4) is seeking a talented young PhD student in organic synthesis and photochemistry. 👩‍🔬Research topic: Synthetic methods promoted by visible light. 🗓️ Deadline: August 15th 💻 Info: buff.ly/3f3sEOf
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If you are interested in a PhD in organic synthesis and photochemistry then have a think about this opportunity in the @NappiGroup! RT is much appreciated! Thanks! More info in our website: nappichem.com/

Home

Chemical reactions promoted by visible light

nappichem.com
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We're happy to share our most recent work in protein modification published in @ChemicalScience! Our vinylheteroarene linkers can chemoselectively functionalise cysteine residues to give stable bioconjugates. @ChemCambridge @CRUK_CI @ASTRAZENECAUK doi.org/10.1039/D1SC02722K
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Check out my most recent publication in Chemical Science! This was a project I have been working on since the start of my PhD, so it's really nice to see it published! Thanks to everyone involved! doi.org/10.1039/D1SC02722K
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Steve Walsh retweeted
Luca Laraia@laraialab2 Jun 2021
I'm looking for a #postdoc in protein #biochemistry to join my lab on a @novonordiskfond funded project on cholesterol transport proteins. Deadline is July 2nd but I will be assessing applications as they come in so apply soon! Please RT and share :) dtu.dk/english/About/JOB-and…
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Check our this review on cyclisation strategies for the stabilisation of peptides with irregular conformations by @YuHengLau and colleagues @rsc_medchem Great summary of #peptidomimetics that recapitulate non-repetitive secondary structure elements pubs.rsc.org/en/content/arti…
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Postdoc post available in my lab to work on transcriptional pathways and endocrine resistance. Hurry up💪💪💪👍🏽 jobs.ac.uk/job/CFP179/resear…
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Have you seen the latest #openaccess Communication from David Spring & colleagues @SpringGroupChem @ChemCambridge? Check out 'A dual-enzyme cleavable linker for antibody–drug conjugates' here 🔓 👇 xlink.rsc.org/?doi=D1CC00957…
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From Natural Product Synthesis, read 'Total synthesis and biological evaluation of simplified aplyronine analogues as synthetically tractable anticancer agents' by Ian Paterson & colleagues @ChemCambridge xlink.rsc.org/?doi=C9CC09050…
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Steve Walsh retweeted
SIMICA@SIMICA_iMM10 Mar 2021
A β-galactose linker for cleavage by lysosomal enzymes to release a toxic payload (MMAE) in targeted cells by @SpringGroupChem et al. pubs.rsc.org/en/content/arti…

A dual-enzyme cleavable linker for antibody–drug conjugates†

A novel enzyme cleavable linker for antibody–drug conjugates is reported. The 3-O-sulfo-β-galactose linker is cleaved sequentially by two lysosomal enzymes

pubs.rsc.org
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We’re happy to share our most recent work into ADC linker chemistry, featuring a highly hydrophilic, dual-cleavable sulfo-galactose motif. Check it out! @ChemCommun @ChemCambridge @CRUK_CI @GSK doi.org/10.1039/D1CC00957E
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Very pleased to share this two-part personal perspective penned by the last few PhD students from Prof Ian Paterson’s group at @ChemCambridge, chronicling Ian’s illustrious >thirty-year career in advance of his retirement later this year (1/5)
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