@SIMICA_iMM

SIMICA is a @EU_Commission Twinning @immolecular to promote scientific excellence & research on therapeutic site-selective protein-modification chemistries

 Lisbon
simica.imm.medicina.ulisboa.pt/#home
Joined November 2019
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  • Followers192
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Our paper on the preclinical efficacy of a highly stable de novo protein decoy against SARS-CoV-2 infection is out! 🥳 @gbernardes_chem @ClaireTang20 @AnaRaquelCoelh5 @neoleukin @IMMolecular academic.oup.com/jid/article…

De Novo Human Angiotensin-Converting Enzyme 2 Decoy NL-CVX1 Protects Mice From Severe Disease After...

We show that NL-CVX1, a de novo human angiotensin-converting enzyme 2 protein decoy that blocks viral cell invasion, prevents severe disease after severe a

academic.oup.com
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"All those experiences made me who I am." From being a taxi driver to becoming a Nobel Prize laureate - 2018 chemistry laureate @francesarnold describes how a diversity of experiences shapes you as a human being.
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🏆 Prof. Gonçalo Bernardes is the recipient of the 2023 EFMC-WuXi AppTec Award for Excellence in Chemical Biology! 🎉 We are delighted to award @gbernardes_chem for his groundbreaking research! #EFMCAward #EFMCWuXiAppTecAward #ChemicalBiologyExcellence #AwardWinner
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Generative AI for protein design is now one click away. We've launched a new platform that puts powerful tools behind a simple web interface, making #proteindesign accessible to anyone. Try it here ➡️ huggingface.co/spaces/merle/… Learn more on YouTube ➡️ youtu.be/bS71K2U0amA
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Proud of this work sponsored by SIMICA about a new metal decaging reaction through C–C bond break by palladium. @IMMolecular
J. Am. Chem. Soc.@J_A_C_S4 May 2023
Expanding Transition Metal-Mediated Bioorthogonal Decaging to Include C–C Bond Cleavage Reactions @EloahLatocheski @JosielBDomingos @UFSC @BilbaoChem @ritafior @ChemCambridge #TransitionMetal #Biorothogonal #Decaging #CCCleavage pubs.acs.org/doi/10.1021/jac…

Expanding Transition Metal-Mediated Bioorthogonal Decaging to Include C–C Bond Cleavage Reactions

Abstract. The ability to control the activation of prodrugs by transition metals has been shown to have great potential for controlled drug release in canc

pubs.acs.org
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Thiomethyltetrazines are reversible covalent cysteine warheads whose reversibility can be "switched off” via live cell bioorthogonal chem, providing stability to lysis/proteomics. Led by @TallonAmanda w/ @Pfizer Mary Xu, Graham West & @ChrisamEnde1 10.26434/chemrxiv-2023-w0p5m
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Excited to invite Dr Emma Yates (co-founder & CSO of Proteotype) presenting on Monday Lecture @IMMolecular today! Amazing and interesting talk about developing a novel technique for early stage cancer diagnosis. @gbernardes_chem
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This paper is finally out! One of the first examples of a Ru(II) photosensitizer for PDT active at 740 nm!
Gasser Group@GasserGroup6 Apr 2023
Check out our @ChemBioChem article on a new organometallic PDT photosensitizer activatable at 740 nm that can be linked to the antibody Cetuximab. Congrats to @astromarta09 and @Agandioso @ChimieParisTech @psl_univ @inc dx.doi.org/10.1002/cbic.2023….
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Tomorrow, Raphaël Rodriguez will present his most recent work about the prevalent role of d-block metals in the regulation of cell plasticity, entitle "Discovery of a metal-driven signaling pathway that regulates cell plasticity". Do not miss it. @institut_curie @immolecular
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I am thrilled to announce that Prof. Gonçalo Bernardes @gbernardes_chem from @Cambridge_Uni has joined @BioconjChem as Associate Editor! Gonçalo brings expertise in protein modification, targeted therapeutics, and bioorthogonal chemistry. gbernardeslab.com/ @ACSPublications
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Fluorescent amino acids are getting SMALLER, acid-stable & compatible for peptide-PAINT. Terrific work led by Fabio & Zuzanna with many collaborators. We share Fmoc/Boc analogues for your peptides, get in touch! @MathewHHorrocks @ERC_Research Free link▶️ onlinelibrary.wiley.com/shar…
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Angela Casini will be in Lisbon to share some great work on bioinorganic chemistry. Don´t loose this opportunity!!🙂
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Congratulations to Rafaela Cavadas, the most recent master @GoisLab, for a very susseceful discussion with @BrunoBioTargtin and @Jpantonio92
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Delighted to share the preclinical studies of JS25, a selective BTK inhibitor, with potent efficacy in blood cancers relative to other BTK inhibitors used in the clinic. A special thank you to all the collaborators and to my supervisor @gbernardes_chem. pubs.acs.org/doi/10.1021/acs…

Selective Inhibition of Bruton’s Tyrosine Kinase by a Designed Covalent Ligand Leads to Potent...

Abstract. Bruton’s tyrosine kinase (BTK) is a member of the TEC-family kinases and crucial for the proliferation and differentiation of B-cells. We evaluat

pubs.acs.org
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Such an amazing SIMICA meeting this week, a lot of fun, science and nice people. Huge thanks to #SIMICA – at Lisbon, Portugal
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Very happy to talk about ADC & bioconjugates from a development and manufacturing perspective at @SIMICA_iMM. This is a side of the history we don’t hear much in R&D and I am so glad with the positive responses! Thanks @gbernardes_chem for the invitation 🤩! @LonzaGroup
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Pharma collaborations happening at @SIMICA_iMM. Talk from Catarina Cardoso - Phagecon.
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The @SIMICA_iMM summer school is on !!!
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Nice @SIMICA_iMM meeting at Octant hotels in Praia Verde!
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Fresh from our oven: Traceless cysteine-linchpin enables precision engineering of lysine in native proteins @chm_iiserb @iiserbhopal @serbonline @IndiaDST @rkmisrb1 @sanjeevtmc @NeeleshChandr13 @RAJIB__MOLLA nature.com/articles/s41467-0…
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