@SpringGroupChem

ADCs, peptides, small molecule drugs and degraders. Student run account @ChemCambridge @Cambridge_Uni.

 Cambridge
Joined March 2013
  • Tweets237
  • Following175
  • Followers960
67Media
The @HyvonenGroup, @SpringGroupChem, Apollo Therapeutics and Sandexis have published a paper in Medicinal Chemistry describing the discovery of APL-5125. This highly selective and potent small molecule CK2a is now in a US Phase 1/2 clinical trial: bioc.cam.ac.uk/news/hyvonen-…
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Happy New Year to all of our followers!🎇 Join us for our next webinar on Protein and Peptide Science on 7th February 1pm UK time. Hear from Dr Sona Krajcovicova (University of Cambridge) & Dr Anna Peacock (University of Birmingham). Register here rsc.org/events/detail/80508/…
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Very sad news of the passing of @sirfrasersays, a giant of chemistry for four decades. He pioneered (with J-P Sauvage) the chemistry of the mechanical bond (catenanes & rotaxanes) & recognised that their well defined motions could be useful for molecular machinery... 1/3
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The @Gaunt_Group are looking for two enthusiastic and talented researchers to join our dynamic team in Cambridge, as postdocs. If you are interested in developing cutting edge synthetic chemistry across a wide range of areas relating to catalysis, apply at jobs.cam.ac.uk/job/49113/
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Amazing paper from the group of my Cambridge colleague Robert Phipps. Great work. science.org/stoken/author-to…

A chiral hydrogen atom abstraction catalyst for the enantioselective epimerization of meso-diols

Hydrogen atom abstraction is an important elementary chemical process but is very difficult to carry out enantioselectively. We have developed catalysts, readily derived from the Cinchona alkaloid...

science.org
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PhD studentship available in the group with @AstraZeneca in iron catalysis! Another inorganic catalysis PhD is also available !🧪🧪 @ChemCambridge jobs.cam.ac.uk/job/48802/
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Come and join our team. We have an exciting Synthetic Chemistry PhD opportunity in the @Gaunt_Group (starting Oct 2025) in collaboration with AstraZeneca. It will focus development of new catalytic activation modes for the synthesis of novel scaffolds. jobs.cam.ac.uk/job/48481/
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Spring Group retweeted
Mahri Park@MahriPark4 Jul 2024
Very excited to see this work published! A huge thank you to our colleagues and collaborators, without whom this would not have been possible! @NicolaAshman6, @JCarrollLab, The Welch Lab and @SpringGroupChem
Chemical Communications@ChemCommun2 Jul 2024
New HOT article from David Spring and first authors @RaoulWalther and @MahriPark at @ChemCambridge 'Tuneable thiol exchange linkers for traceless drug release applications in prodrugs and ADCs' 🔥🔓 pubs.rsc.org/en/content/arti…

Tuneable thiol exchange linkers for traceless drug release applications in prodrugs and ADCs†

We describe a versatile and tuneable thiol responsive linker system using thiovinylketones, which relies on the conjugate addition–elimination mechanism of

pubs.rsc.org
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Mahri Park @MahriPark on cool Fc display of peptides #esboc57
Mahri Park

ALT Mahri Park

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Thomas Wharton on self-immolative release of amine-containing drugs. Check out his recent paper: onlinelibrary.wiley.com/doi/…
Thomas Wharton

ALT Thomas Wharton

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The list of most-accessed papers in the past month includes contributions by @MaulideLab, @springgroupchem, @ICIQchem, @sumansar8, @xiao4538435, @BristolChem, @ChXinjian What else? See the full list. ow.ly/kjUK50RFjeu
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Unlocking Amides: A General Method for the Self-Immolative Release of Amide-Containing Molecules (David R. Spring) @springgroupchem @Cambridge_Uni #openaccess onlinelibrary.wiley.com/doi/…

Unlocking Amides: A General Method for the Self‐Immolative Release of Amide‐Containing Molecules

Methodologies for the self-immolative release of amide motifs remain scarce despite the prevalence of amides in molecules. Herein, is presented a general and comprehensive strategy for the selective...

onlinelibrary.wiley.com
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Congratulations Tom Wharton on winning the RSC Medicinal Chemistry Poster Prize at the @RSC_CBBG forum last week👏 @SpringGroupChem
This Post is from an account that no longer exists. Learn more
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Spring Group retweeted
SEQT@SocEspQuimTerap26 Jan 2024
📢#SEQT_articles Red-light modulated ortho-chloro azobenzene photoswitch for peptide stapling via aromatic substitution and its application for the inhibition of MDM2/p53 interaction as a proof-of-concept Authors: @dr_illo @SpringGroupChem 🔗pubs.rsc.org/en/content/arti…
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New from David Spring and first author Jack Sydenham: 'Site-selective peptide functionalisation mediated via vinyl-triazine linchpins' 🔓 @SpringGroupChem, @ChemCambridge bit.ly/3RF9Jvm bit.ly/3RF9Jvm

Site-selective peptide functionalisation mediated via vinyl-triazine linchpins†

Herein we introduce 3-vinyl-1,2,4-triazines derivatives as dual-reactive linkers that exhibit selectivity towards cysteine and specific strained alkynes, e

pubs.rsc.org
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One more of the most read ChemComm Communications this year: 'Peroxide-cleavable linkers for antibody–drug conjugates' by @SpringGroupChem and first author @NicolaAshman6 🔓 bit.ly/473NiFO bit.ly/473NiFO
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Read this #openaccess study by Dr David Spring et al., on peptide stapling using photoswitchable linkers for potential therapeutic applications 😍. Read the full article below 👇 DOIhttps://doi.org/10.1039/D3CB00176H
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When you accidentally girlbossed a little too hard, and now you’re on the cover of the Chemistry at Cambridge Magazine 💅🏼😅😅 Truly honored and very grateful @ChemCambridge 🫶 📸: Nathan Pitt 🙏🙏🙏
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Delighted to share my latest interview from #ELRIG where I talk about how the simple passion for orgchem could lead to some pretty cool things in the lab 😁 Thank you @AZoNetwork for this opportunity 🙏 👉 news-medical.net/news/202311…
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Speaker 3 of the morning session is Mahri Park from University of Cambridge @SpringGroupChem. Her talk is on efficient semisynthetic peptide-containing Fc-fusion compounds #PPSG2023
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