ADCs, peptides, small molecule drugs and degraders. Student run account @ChemCambridge @Cambridge_Uni.
Cambridge
Joined March 2013
- Tweets237
- Following175
- Followers960
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Check out our new paper, "Towards a glutathione-cleavable azobenzene linker for antibody–drug conjugates"
pubs.rsc.org/en/content/arti…
We're very excited to see our very own David Spring winning the Outstanding Investigator award at the World ADC Awards. Well deserved!
Spring Group retweeted
The @HyvonenGroup, @SpringGroupChem, Apollo Therapeutics and Sandexis have published a paper in Medicinal Chemistry describing the discovery of APL-5125. This highly selective and potent small molecule CK2a is now in a US Phase 1/2 clinical trial: bioc.cam.ac.uk/news/hyvonen-…
Amazing and elegant work!
We are excited to share our new work on one carbon alkene homologation. We can iteratively homologate terminal and internal alkenes in simple and complex molecules using this method. Great work by Marcus that opens up lots of exciting opportunities for us. nature.com/articles/s41586-0…
Congratulations to our very own first-year student Georgie Bonney for winning the poster prize today at @AstraZeneca student symposium in Cambridge!
A Platform for SpyCatcher Conjugation to Native Antibodies
Out now in @ChemicalScience
pubs.rsc.org/en/content/arti…
Check out our newest paper in @ChemEurJ: Advances in the Release of Amide-Containing Molecules!
chemistry-europe.onlinelibra…
A great read!
#RachelBrazil examines progress by researchers to create a new generation of antibody drug conjugates to improve efficacy and minimise off-target adverse effects of these cancer therapies
#Enhertu #enfortumabvedotin #antibodydrugconjugate
pharmaceutical-journal.com/a…
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Happy New Year to all of our followers!🎇
Join us for our next webinar on Protein and Peptide Science on 7th February 1pm UK time.
Hear from Dr Sona Krajcovicova (University of Cambridge) & Dr Anna Peacock (University of Birmingham).
Register here rsc.org/events/detail/80508/…
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Very sad news of the passing of @sirfrasersays, a giant of chemistry for four decades. He pioneered (with J-P Sauvage) the chemistry of the mechanical bond (catenanes & rotaxanes) & recognised that their well defined motions could be useful for molecular machinery... 1/3
#SpringleMingle’s in Action: Congratulations to Saan Voss (@peptidestudio) for bringing home the 1st Luis Moroder award for the best conference presentation at the 18th peptide workshop in Naples!
It's also time that we welcome new PhD students Aryaman, Georgie, Sophie and Josh to the group! We've loved having you thus far and can't wait to see the amazing science you get up to over the next 3/4 years.
A wonderful group away day @TrinCollCam filled with excellent science, great food and lovely chat. A big thank you to Sarah and Daria for organising!
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The @Gaunt_Group are looking for two enthusiastic and talented researchers to join our dynamic team in Cambridge, as postdocs. If you are interested in developing cutting edge synthetic chemistry across a wide range of areas relating to catalysis, apply at jobs.cam.ac.uk/job/49113/
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Amazing paper from the group of my Cambridge colleague Robert Phipps. Great work. science.org/stoken/author-to…
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PhD studentship available in the group with @AstraZeneca in iron catalysis! Another inorganic catalysis PhD is also available !🧪🧪 @ChemCambridge
jobs.cam.ac.uk/job/48802/
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Come and join our team. We have an exciting Synthetic Chemistry PhD opportunity in the @Gaunt_Group (starting Oct 2025) in collaboration with AstraZeneca. It will focus development of new catalytic activation modes for the synthesis of novel scaffolds.
jobs.cam.ac.uk/job/48481/
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Very excited to see this work published! A huge thank you to our colleagues and collaborators, without whom this would not have been possible!
@NicolaAshman6, @JCarrollLab, The Welch Lab and @SpringGroupChem
New HOT article from David Spring and first authors @RaoulWalther and @MahriPark at @ChemCambridge
'Tuneable thiol exchange linkers for traceless drug release applications in prodrugs and ADCs' 🔥🔓
pubs.rsc.org/en/content/arti…
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Thomas Wharton on self-immolative release of amine-containing drugs. Check out his recent paper:
onlinelibrary.wiley.com/doi/…
ALT Thomas Wharton