@samit2104

PhD candidate👨‍🔬 @Biozentrum, University of Basel #CellBiology 🧫 🔬#EndosomeMaturation

 Basel, Switzerland
Joined May 2013
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  • Following388
  • Followers33
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ARF-1 coordinates cargo sorting at FERARI endosomal recycling hubs rupress.org/jcb/article-abst…

ARF-1 coordinates cargo sorting at FERARI endosomal recycling hubs

Sorting in the endosomal system is critical to cellular homeostasis. How the directionality of cargo flow is achieved is still not entirely clear. Solinger

rupress.org
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Happy to share our new preprint on endocytic lysosome reformation. Many thanks to Prof. Anne Spang for her guidance and support throughout this work.
The Spang Lab@Spang_LabJan 30
Replying to @Spang_Lab
Check out our newest findings on how #lysosomes are generated from #endolysosomes. Great work from @samit2104 ! @biozentrum @UniBasel_en #cellbio Ca2+ and DRP1 drive endocytic lysosome reformation at tripartite contact sites biorxiv.org/content/10.64898…
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Congratulations to Anne Spang @SpangLab for being elected as a new #AAASFellow 2024 by @aaas ! The world’s largest scientific society recognizes her outstanding contributions to the field of cell #biology and #biochemistry. @biozentrum @unibas_en biozentrum.unibas.ch/news/de…

Anne Spang awarded distinction of AAAS Fellow

The AAAS has elected Prof. Anne Spang at the Biozentrum, University of Basel, as a Fellow. With this honor, the world’s largest scientific society recognizes her outstanding contributions to the...

biozentrum.unibas.ch
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Samit Desai retweeted
The Spang Lab@Spang_Lab5 Feb 2025
Check out our latest paper! Congrats to Daniel Ott @Samit2104 and Jachen Solinger! well done! Coordination between ESCRT function and Rab conversion during endosome maturation | The EMBO Journal embopress.org/doi/full/10.10…
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Congratulations to Anne Spang @Spang_Lab for receiving the renowned Lelio Orci Award. The award honors her pioneering work in intracellular organization and her research achievements in Cell Biology. @LS2Switzerland @UniBasel_en biozentrum.unibas.ch/news/de…
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Honored to collaborate with @petrovic_iv on our latest research! We investigated the effect of CCR5 phosphorylation on internalization and arrestin’s interaction with the endocytic machinery. Check out our findings. Hope it inspires new ideas in the field!
ivanapetrovic@petrovic_iv5 Nov 2024
🚨 New preprint alert! 🚨 We analyzed how #receptor phosphorylation modulates #arrestin interactions with the proteins of the endocytic machinery. Big thanks to my amazing co-authors @samit2104 @Spang_Lab and @AbikoLayara @isaikina_p! #NMR #GPCR biorxiv.org/content/10.1101/…

A high-resolution analysis of arrestin2 interactions responsible for CCR5 endocytosis

Clathrin-mediated endocytosis (CME) is crucial for regulating G protein-coupled receptors (GPCRs) via phosphorylation-dependent arrestin interactions. The interplay between receptor phosphorylation...

biorxiv.org
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Glad to have contributed to this great work led by the one and only Akriti Prashar @SickKidsNews @NicolaJGI, now @Nature! Introducing here VDIMs (vesicles derived from the IMM) as new pathway of intramitochondrial QC #Lysosomes #Mitochondria nature.com/articles/s41586-0… 😍
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🥧Fresh from the oven 🥧 #GPCR #BiasedSignaling We've uncovered the molecular mechanism behind β1AR arrestin-biased signaling using #NMR. Here is a teaser of our main findings: 1/5 biorxiv.org/content/10.1101/…

Biased agonism of carvedilol in the β1-adrenergic receptor is governed by conformational exclusion

G protein-coupled receptors (GPCRs) are the therapeutically most important family of receptors in the human genome. The selective activation of specific signaling pathways, termed biased signaling,...

biorxiv.org
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Have you ever wondered how different processes talk to each other?checkout our newest preprint! Congratulations Daniel Ott! Coordination between ESCRT function and Rab conversion during endosome maturation biorxiv.org/content/10.1101/…

Coordination between ESCRT function and Rab conversion during endosome maturation

The endosomal pathway is essential for regulating cell signaling and cellular homeostasis. Rab5-positive early endosomes receive proteins from the plasma membrane. Dependent on a ubiquitin mark on...

biorxiv.org
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Telling the story of endolysosome maturation at Biozentrum symposium 2023 #biozentrum
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We had an interactive course on ‘Effective Visual Communication of Science’, during which we learned to transmit our scientific ideas and results by applying the best visual communication practices to our research communication. Stay tuned and join the next courses!
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The team of @bengeliscious @biozentrum @UniBasel_en together with @goetheuni and @SchullerJm @Uni_MR have revealed how the enzyme HDCR performs high-speed storage of #CO2 in #bacteria. New ideas to store CO2 are needed to address the #climate crisis. bit.ly/3ROcFFm
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Started new journey as a PhD candidate at the Biozentrum, University of Basel. Excited to start my work in the field on endolysosome machinery. Together with the project and lab, this view is worth coming all the way here😃😃😍😍.
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