@SabanLab

Immunologist leveraging the eye to study #neuroimmunology #mucosalimmunology #immuneprivilege #macrophage https://xitter.cf/t.co/cV5V7O7kzs

youtube.com/channel/UCSQcXResQ4yb4RofJVvZI_A
Joined January 2011
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382Media
Danny Saban retweeted
IdoAmitLab@IdoAmitLabOct 16
What comes after M1/M2? In our Perspective with @FGinhoux in @ImmunityCP we explore how single-cell technologies and AI can decode the gene programs macrophages use across tissues & microenvironments, and how this modular view could transform immunotherapy cell.com/immunity/abstract/S…

Embracing macrophage complexity for research and translation

Ginhoux, Mulder, Arcila-Barrera, and Amit argue that macrophage identity is best understood not as a set of discrete subsets or a binary M1/M2 axis but as combinations of modular gene programs. They...

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A few more hours to place a bid on this piece! Money does not go to me, but to the child neurology foundation @Child_Neurology . pro.gofundme.com/live/auctio…
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🪄Regeneration is a conversation between stem cells and their surroundings. 🥳I’m excited to share our new review on the expanding landscape of stem cell niches and how understanding stem cell–niche dialogue could advance tissue repair and healthy aging 💪🏽 sciencedirect.com/science/ar…
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Danny Saban retweeted
Amir Giladi@AmirGiladiOct 10
This has been an exciting journey, and our paper is finally out as a preprint! Together with @chihyaochung and in collaboration with Agnel Sfeir, we developed mtDIVE to explore the functional consequences of thousands of mitochondrial DNA variants biorxiv.org/content/10.64898… 1/12

Random mtDNA mutagenesis maps genotype-phenotype associations across metabolic contexts and lineages

Mitochondrial DNA (mtDNA) mutations cause inherited disease, accumulate with age, and recur in tumors, yet their effects remain unresolved because existing models interrogate one engineered allele at...

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📢 To everyone on the job market who has a vision for neuroscience applied to biomedical applications & technological innovation: The Duke Dept. of Biomedical Engineering announces a tenure-track faculty job search in neural engineering, broadly defined! academicjobsonline.org/ajo/j…
View of Duke Chapel looking up a quiet street surrounded by colorful autumn foliage

ALT View of Duke Chapel looking up a quiet street surrounded by colorful autumn foliage

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Danny Saban retweeted
IdoAmitLab@IdoAmitLabSep 14
New dates, same ReThink spirit! 🏄 Join us at Weizmann, May 24–26, 2027, for 3 days of bold ideas and lively discussions shaping the future of neuroimmunology. Explore our speakers and register: conferences.weizmann.ac.il/R… #ReThinkNeuroimmunology
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Danny Saban retweeted
Claudia Han@CeeZeeHSep 2
One unsolicited piece of advice for new #gradstudents. Don't settle on ALL of your #rotations before school starts. Use the first semester to explore. Talk to people! Check out labs and areas that you haven't considered! Go outside of your comfort zone! Let yourself be surprised!
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Danny Saban retweeted
Moshe Biton@bitonmAug 28
🎉 Excited to share our new paper in Immunity! Can a tissue remember inflammation after the inflammation itself is gone? We find that it can—and that this memory can be stored in an unexpected place: the extracellular matrix (ECM). 🧵👇 cell.com/immunity/abstract/S…

Long-lasting extracellular matrix modifications reshape intestinal stem cell fate and promote...

Whether inflammation leaves a lasting imprint on the intestinal stem cell (ISC) niche has remained unknown. Adir et al. find that persistent modified ECM (modECM) encodes inflammatory memory,...

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Danny Saban retweeted
Rotem Shalita@Rotem_ShalitaAug 28
Excited to share our new Perspective in @natBME! What if drug development could learn continuously from the data generated along the way? We propose a data-driven framework to turn biological and clinical data into a feedback loop for designing better immunotherapies
IdoAmitLab@IdoAmitLabAug 28
Genomic data generation is exploding. Translation into new therapies is not. Our new @natBME Perspective proposes data-centric feedback loops combining ML, single-cell genomics & in vivo perturbations to accelerate next-gen immunotherapy @Rotem_Shalita nature.com/articles/s41551-0…
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New paper from the Colonna lab! cMAF is a key regulator of BAM identity and drives communication with brain arteries via IGF1. We show that this cMAF-dependent program in BAMs supports cerebrovascular function in mice and is protective against AD. cell.com/cell/fulltext/S0092…

Brain perivascular macrophages regulate endothelial cell function via a cMAF-dependent transcript...

This study identifies cMAF as a key transcription factor that orchestrates the molecular crosstalk between brain perivascular macrophages and arteries, thereby sustaining cerebrovascular function in...

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Danny Saban retweeted
Eric Topol
@EricTopolAug 12
Contradicting an influential 2023 study that claimed science progress has slowed and there is a notable decline in disruption, today's @Nature paper claims that's not true and was attributable to data artifacts nature.com/articles/s41586-0… economist.com/science-and-te…
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Academic biomedical research is national defence dlvr.it/TTtvVc

Academic biomedical research is national defence

Nature Reviews Immunology - Academic biomedical research is national defence

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Our new study, led by @JoonHyukLee3 , is out today in @Nature! We discovered a population of CD40+MHC-II+ astrocytes that present antigens to CD4+ T cells, enhancing pathogenic Th17 responses and promoting CNS autoimmunity. nature.com/articles/s41586-0…

Antigen presentation by CD40+MHC-II+ astrocytes promotes CNS autoimmunity

Nature - Astrocytes promote central nervous system (CNS) immunity through antigen presentation and activation of CD40 in astrocytes by CD40L expressed by CD4+ T cells in a model of experimental...

nature.com
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Danny Saban retweeted
John Lukens@LukensJohnRAug 5
Antigen presentation by CD40+MHC-II+ astrocytes promotes CNS autoimmunity nature.com/articles/s41586-0… @Nature
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Danny Saban retweeted
Rony Dahan@DahanLabAug 5
1/ Why have anti-GITR agonists, despite strong preclinical activity, shown limited clinical success? Our new study in @NatureCancer points to Fc receptor pathways as a key missing piece. Led by the amazing @AvYahel, Natasha Barth nature.com/articles/s43018-0…

Fc-optimized GITR antibody enhances a CD4 T cell–dendritic cell crosstalk to promote antitumor...

Nature Cancer - Avraham et al. engineered an anti-GITR human antibody with an optimized Fc domain that engages the activating Fcγ receptors IIa and IIIa to enhance antitumor efficacy through...

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Danny Saban retweeted
IdoAmitLab@IdoAmitLabAug 4
Congratulations Chris @UCSDGlassLab on this beautiful paper! cell.com/immunity/fulltext/S…

Lysosomal dysfunction drives a transcriptional and epigenetic signature found in disease-associated...

Lysosomal dysfunction is associated with neurodegeneration. Balak et al. examine the cell-specific effects of lysosomal dysfunction in an MPS-IIIA (Sgsh−/−) model and find that microglia are dispro...

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Danny Saban retweeted
IdoAmitLab@IdoAmitLabJul 30
Beautiful study lead by Julia, Howard, Siddhartha and co. follows the ontogeny of microglia in human aging nature.com/articles/s41586-0…

Somatic mutations reveal the ontogeny of microglia in human ageing

Nature - A widespread influx of myeloid cells into the healthy human brain contributes to the pool of human microglia and becomes common with ageing.

nature.com
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Danny Saban retweeted
IdoAmitLab@IdoAmitLabJul 15
📢 New dates for ReThink Neuroimmunology: May 24–26, 2027, at the Weizmann Institute of Science. Join our spectacular international speaker lineup for bold science and deep discussions. Registration is open. Space is limited: conferences.weizmann.ac.il/R… #RTN2027 #Neuroimmunology
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Excited to share our Review in @NatImmunol with @HepingXuLab_WU! We discuss how tissue environment, differentiation, time of residency and inflammation shape eosinophil identity and function. nature.com/articles/s41590-0…

Rediscovering eosinophil identity through tissue adaptation

Nature Immunology - In this Review, the authors discuss the immunology of eosinophils beyond their roles in allergy and type 2 immune responses, focusing on the adaptation and heterogeneity of...

nature.com
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In the latest issue of VISION magazine, we reflect on the impact of Edward Buckley, MD.
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