@TheColonnaLab
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We study innate immunity with a focus on ILCs, macrophages, and DCs. The account is led by trainees. @wusm_pathology @WUSTLmed
St. Louis, MO
Joined April 2021
- Tweets105
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The Colonna Lab retweeted
The transcription factor MAF is known from human genetics to be important in Alzheimer’s disease, but its precise function within the brain has been unclear.
Our latest, out today in @CellCellPress, dissects the role of MAF in brain macrophages. 1/
cell.com/cell/fulltext/S0092…
New paper from the Colonna lab! cMAF is a key regulator of BAM identity and drives communication with brain arteries via IGF1. We show that this cMAF-dependent program in BAMs supports cerebrovascular function in mice and is protective against AD.
cell.com/cell/fulltext/S0092…
The Colonna Lab retweeted
Gaining therapeutic access to the human brain is one of the biggest unsolved problems in biomedical science.
Today @nature, we uncover a massive influx of immune cells into the human brain during aging, revealing that the brain is more accessible than previously thought. 1/
nature.com/articles/s41586-0…
The Colonna Lab retweeted
Online now: Age- and tissue-dependent diversity of human plasmacytoid dendritic cells uncovers a cycling subset dominant in early life and cancer dlvr.it/TSHW39
What defines human pDC diversity? Our newest work led by @UlezkoAlina in @ImmunityCP uncovers a complex landscape shaped by age and tissue niche, including a cycling pDC subset that declines with age but persists in the BM & expands in malignant BPDCN. shorturl.at/99Zui
Excited to share our latest work in J Exp Med! We identify LINGO4 as a key regulator of ILC3 fitness, IL-22 production and microbiota homeostasis, with major impact on host defense against enteric infection. Check it out!
doi.org/10.1084/jem.20252632
Our study is out in @ScienceMagazine! It shows that CAR-expressing astrocytes (CAR-A) can recognize and clear amyloid aggregates, reducing pathology and restoring microglial homeostasis in AD models.
Led by Yun Chen, Alex Liu and @khainotkaiorky!
doi.org/10.1126/science.ads3…
The Colonna Lab retweeted
Genetically altered astrocytes that express chimeric antigen receptors offer a promising immunotherapy system capable of clearing accumulations of amyloid-β in the brains of mice—a hallmark pathological feature of #AlzheimersDisease, according to a new study in Science.
📄: scim.ag/3NjPIfP
#SciencePerspective: scim.ag/4rgI1oL
The Colonna Lab retweeted
Platelet-derived growth factor D (#PDGFD) binds to PDGFRβ in #ILC3s in mice and NKp44 in human ILC3s, promoting divergent innate immune responses following intestinal infections. @TheColonnaLab
Learn more in Science #Immunology: scim.ag/4aXJmL1
Excited to share our new work in @SciImmunology, led by @zefachi! Mesenchymal cells produce PDGF-D during colitis, driving species-specific ILC3 programs: via PDGFRβ in mice (IL-22, repair) and NKp44 in humans (type I response, pathogen clearance).
science.org/eprint/EFDJ3BJRF…
The Colonna Lab retweeted
Online now: Immunity in Alzheimer’s disease: From mechanisms to therapies dlvr.it/TR9xxM
How do microglia and T cells shape Alzheimer’s? We review the stage-specific roles of innate and adaptive immunity, from genetic risk factors to precision therapies. Is the immune system a guardian or a saboteur?
check out in our review in Immunity: authors.elsevier.com/a/1mgnQ…
The Colonna Lab retweeted
A new Science #Immunology study pinpoints the developmental origin of a distinct group of #DendriticCells that express the transcription factor #RORγt and highlights molecular players that regulate this process. scim.ag/45vKMue
Excited to share that our work by @PatFernRod & @TongWu99 is published: RORγt⁺ DCs are a distinct lymphoid-derived lineage whose development is controlled by REV-ERBα/β, PRDM16 and PU.1, enabling pTreg induction and protection from Th2-skewed responses.
rb.gy/lyvce8
Our new study led by Bishan Bhattarai shows that circadian proteins REV-ERBα/β protect gut health by maintaining ILC3 homeostasis. Without them, ILC3s turn into IFNγ+ ILC1s, fueling inflammation.
Chick it out!
nature.com/articles/s41590-0…
Check out Research Briefing for our recent paper in Nature Immunology @DuSiling
nature.com/articles/s41590-0…
The Colonna Lab retweeted
🧵1/
Excited to share my first publication from the @ColonnaLab in @NatImmunol! We investigated how mutations in the human CSF1R gene disrupt microglia and impair white matter integrity in a rare but devastating neurodegeneration called ALSP.
nature.com/articles/s41590-0…
Our new study by @DuSiling reveals how CSF1R mutations in adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) disrupt glial homeostasis. Key roles for oligodendrocytes, astrocytes & STAT3 signaling.
nature.com/articles/s41590-0…
Congrats to @KedmiRanit’s group! RORγt⁺ APCs prime food-specific pTregs and induce oral tolerance. Infection or food poisoning temporarily bypasses this, allowing CD8αβ T cell responses to mimicked food antigens without breaking long-term oral tolerance. nature.com/articles/s41586-0…
Big shoutout to Brown’s group: IRF8-dependent TC are essential for inducing food-specific pTregs & establishing oral tolerance! In line with recent work from Mucida’s, Littman’s, Gardner’s, and our group highlighting the role of RORγt⁺ APC in this process.rb.gy/rej77q
As RORγt⁺ APC gain attention for their tolerogenic roles, Schraml’s group also highlights their inflammatory potential. Key questions remain: How are RORγt⁺ APC specified? Are eTAC and RORγt⁺ DC distinct or the same? What dictates tolerance vs. inflammation? Fast-moving field!
Find the referenced papers below:
Brown: rb.gy/rej77q
Mucida: rb.gy/1ulzqt
Littman: rb.gy/9v8ke8
Gardner: shorturl.at/vTk7k
Schraml: rb.gy/yhw499
Colonna: rb.gy/w50y70