@SCS_DMCCB

Everything about Swiss #MedChem and #ChemBio. Led by the Division of Medicinal Chemistry and Chemical Biology (#DMCCB) of the Swiss Chemical Society

 Berne, Switzerland
scg.ch/dmccb/
Joined September 2015
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  • Followers557
67Media
Do you want to learn more about conferences that we co-organize outside of Switzerland? The report of the FiMC, co-organized by the SCS 🇨🇭and GDCh 🇩🇪, was published in ChemMedChem 💊🧬🧫 chemistry-europe.onlinelibra…

A Warm Welcome to MedChem: The Frontiers in Medicinal Chemistry 2025

The Frontiers in Medicinal Chemistry (FiMC) is the largest international Medicinal Chemistry conference in Germany and took place from April 1st to 4th, 2025, in Erlangen. This conference report...

chemistry-europe.onlinelibrary.wiley.com
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📯 Paper Alert 📯 A study published in @ChemMedChem describes the identification of a potential positron emission tomography (PET) imaging agent targeting the NLRP3 protein. chemistry-europe.onlinelibra… @Novartis 🧫💊

[18F]NP3‐627, a Candidate PET Imaging Agent Targeting the NLRP3 Inflammasome in the Central Nervous...

Illuminating the NACHT. A series of pyridazine-based NLRP3 inhibitors was optimized towards the profile of an imaging agent for positron emission tomography. Compound 17 b has all the desired...

chemistry-europe.onlinelibrary.wiley.com
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Using pyridazine-based inhibitors as a starting point, the research team leveraged their improved permeability and brain-penetrant properties to develop imaging agents for NLRP3 that could help measure both target expression and occupancy by a drug in the CNS.
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It’s hoped that the resulting agent, [18F]NP3-627,  could enable the clinical development of drugs acting on the NLRP3 inflammasome, lead to a better understanding of their target engagement and optimal dose, and help stratify patients and monitor disease progression.
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📯 Paper Altert 📯 In the Journal of Medicinal Chemistry, researchers from @Novartis describe the discovery, characterization, and optimization of a series of pyridazine-based NLRP3 inhibitors, including lead molecule NP3-253. 🧫💊 pubs.acs.org/doi/10.1021/acs…

Discovery of NP3-253, a Potent Brain Penetrant Inhibitor of the NLRP3 Inflammasome

Abstract. Activation of the NLRP3 inflammasome in response to danger signals is a key innate immune mechanism and results in the production of the pro-infl

pubs.acs.org
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NP3-253 displayed good efficacy and tissue & brain penetrance. The study also elucidated the molecule’s mechanism as a  NLRP3 inhibitor.
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NP3-253 is expected to be a useful tool to further study NLRP3 inhibition, especially in the central nervous system (CNS) in neuroinflammatory conditions.
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SwissMedChemBio retweeted
EFMC@EuroMedChem15 Nov 2024
🏆 EFMC-YSN PhD Prize 2025 🏆 Applications are now open! The EFMC-Young Scientists Network recognizes excellence by awarding a European PhD student in medicinal chemistry or chemical biology 🔗 Apply here: buff.ly/3sykmYD ⏱️ Deadline: January 31, 2025
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Simon Braun@smgbraun3 Oct 2024
🚨#JobAlert🚨 Join us in Geneva @unige_en! We have an open #postdoc position starting in 2025. If you are interested in studying chromatin regulation and working with brain organoids, apply now! #sciencejobs More info: unige.ch/medecine/gede/en/re…
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Just a few days left (Oct 9) to submit your abstract for OC! Check the list of confirmed speakers and register to not miss your chance to be part of #EFMCISCB25! @EuroMedChem @SCS_DMCCB @YoungSciNet
Gianluca Sbardella@g_sbardella20 Sep 2024
Don’t miss your chance to be part of the #EFMCISCB25!Submit your abstract for an Oral or a Poster Communication by October 9 and showcase your research to a focused audience of Chemical Biologists and Medicinal Chemists. efmc-iscb.org/
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Kathrin Lang@klanglab5 Oct 2024
🔥 We have two open full prof positions at our institute (LOC) at @ETH_DCHAB @ETH_en 1. Synthetic Organic Chemistry 2. (Bio)Analytical Chemistry Apply until Nov 15 and be our colleague! ethz.ch/en/the-eth-zurich/wo…
Morandi Lab@morandilab3 Oct 2024
Come be our colleague 👇. Two positions (synthetic organic and (bio)analytical) open at our institute (LOC). Amazing students and staff, colleagues, facilities, location, and long-term funding perspectives. What are you waiting for? Apply today 😀. @ETH_DCHAB #chemjobs
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Don’t miss your chance to be part of the #EFMCISCB25!Submit your abstract for an Oral or a Poster Communication by October 9 and showcase your research to a focused audience of Chemical Biologists and Medicinal Chemists. efmc-iscb.org/
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🚨 Your Opinion Matters! 🚨 We’re gearing up for the Basel Symposium 2025, and we want YOU to help shape the event. 🗳️ Cast your vote now for the topic you’re most excited to explore on February 6, 2025 🌟 strawpoll.com/GJn4442Dqnz

Choose the Basel Symposium 2025 Topic - StrawPoll

What is your opinion? Vote now: Strategies for Addressing Challenging Targets, Innovations in Next-Generation Cancer Therapies, New Therapeutic and Uncharted Target Families

strawpoll.com
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This week on the front cover of ChemMedChem: Developing Low Molecular Weight PET and SPECT Imaging Agents chemistry-europe.onlinelibra… Congratulations on this outstanding work and the beautiful cover L. Xue, C.M.L. Jie, S. Desrayaud and @YvesAuberson from @NovartisScience in Basel!

Front Cover: Developing Low Molecular Weight PET and SPECT Imaging Agents (ChemMedChem 15/2024)

The Front Cover shows the clinical demands that drive the development of novel imaging agents for positron emission tomography (PET) or single-photon emission computed tomography (SPECT). Multiple...

chemistry-europe.onlinelibrary.wiley.com
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⏰ The registration deadline for the Peptide Therapeutics Forum 2024 is approaching (this Friday!) 💊🧫🧬 Please join us for a fantastic day of peptide science in Basel on August 22 & 23! ptf24.scg.ch/registration

Registration

ptf24.scg.ch
Swiss Chemical Society@SwissChemistry5 Aug 2024
‼️Last chance to register for the Peptide Therapeutics Forum 2024 🗓️Aug 22-23 @biozentrum University of Basel ptf24.scg.ch/registration #ptf24 #peptides #chemistry #scs #medchem #chembio #symposia #switzerland
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SwissMedChemBio retweeted
Nina Hartrampf@NinaHartrampf18 May 2024
Our chemoenzymatic synthesis of the lasso peptide Microcin J25 is out now in @J_A_C_S! We used flow-SPPS to synthesize several sidechain- and backbone-modified precursor peptides and demonstrated their in vitro transformation. pubs.acs.org/doi/10.1021/jac… @UZH_Chemistry @Hartrampf_Lab

Merging Flow Synthesis and Enzymatic Maturation to Expand the Chemical Space of Lasso Peptides

Abstract. Many peptidic natural products, such as lasso peptides, cyclic peptides, and cyclotides, are conformationally constrained and show biological sta

pubs.acs.org
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Bode Group@bode_lab14 May 2024
Would you like a data set of 40,000 reactions for evaluating your reactivity prediction models? We made it, so you don’t have to. 1/10
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SwissMedChemBio retweeted
SNE ChemBio@SNE_ChemBio15 May 2024
📢Good news! The program for the @SNE_ChemBio retreat on June 3-4, 2024, is now available! Join us to dive into enlightening sessions, hear from esteemed speakers, and enjoy the breathtaking scenery of Champèry, Valais 🗓️Check out the agenda here 👉 bit.ly/44Gibkc
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📣 18th EFMC-YSN MedChemBioOnline | Registration is Open! 📅 June 11, 2024 | 16:30 - 18:30 CEST 💻 Virtual Event 🔗 medchembio.online #MedChemBioOnline #EFMCYSN #ChemicalBiology #MedicinalChemistry #EarlyCareerScientists #Webinar
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🌸 The May edition of MedChemBioWatch is now available! Stay informed about the latest activities of EFMC, upcoming events and so much more... 🔗 efmc.info/medchemwatch.php?l… #MedChemBioWatch #EFMC #MedChem #ChemBio
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