translational Neuroproteomics Lab | We study protein (dis)aggregation in ALS/FTD, AD, and other neurodegenerative proteinopathies. (Views are my own.)
Jacksonville,FL
Joined March 2019
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Wilfried Rossoll retweeted
In partnership with @aging_mind, @alzassociation, and @CurePSP we recently hosted the 2025 #TauopathyChallengeWorkshop and are excited to announce the grantees who will receive a total of $2.5 million in funding to advance their neurodegenerative research: bit.ly/412dMaN
Wilfried Rossoll retweeted
Excited to share our latest work! We asked if and how TDP-43 regulates RNA transport in neurons and if this is misregulated in ALS. We found that it works to keep RNAs *out* of neurites, and that loss of TDP-43 activity results in specific RNAs aberrantly accumulating there.
Wilfried Rossoll retweeted
Introducing mipDVP (multiplexed imaging-powered Deep Visual Proteomics)! Using 22-marker imaging to profile proteomes across hot/cold tumors, revealing immune microenvironments, macrophage barriers to T cells, & hypoxic adaptations. Out in @MolecularCell
doi.org/10.1016/j.molcel.202…
Wilfried Rossoll retweeted
If Nature and Science journals both agree on this, surely there is at least a 60% chance it is true. nature.com/articles/d41586-0…
Wilfried Rossoll retweeted
Excited to share our latest work! We developed a new method for studying RNA localization via proximity labeling: OINC-seq! In contrast to other proximity methods, labels deposited on RNAs are read directly by sequencing without a need for biotinylation. biorxiv.org/cgi/content/shor…
Wilfried Rossoll retweeted
APEX peroxidase is a versatile tool for proximity labeling and electron microscopy (EM) but its requirement for toxic H2O2 is a liability. We now report LaccID, a multicopper oxidase evolved from an ancestral fungal laccase that oxidizes aromatic substrates using non-toxic O2 instead of H2O2. We use LaccID for EM imaging of cultured cells and fly brains, and for proteomic mapping of the changing surface composition of T cells that engage with tumor cells via antigen-specific T cell receptors.
Wilfried Rossoll retweeted
introducing the folding phase-check out our new opinion article in which we propose a protein folding function of the nuclear pore complex: sciencedirect.com/science/ar…
Wilfried Rossoll retweeted
We are coming off three days of outstanding discussions and collaboration to advance pre-clinical ALS research. Our biennial ALS Research Symposium brought together more than 100 early-career researchers from across the globe. Safe travels home, everyone! #livelikelousymposium
Wilfried Rossoll retweeted
Heteromeric amyloid filaments of ANXA11 and TDP-43 in FTLD-TDP Type C biorxiv.org/cgi/content/shor… #bioRxiv
Wilfried Rossoll retweeted
Surprise - FTLD-TDP Type C is a dual proteinopathy! Annexin A11 co-accumulates with TDP-43 in all cases of FTLD-TDP Type C. #annexinopathy
#FTD #dementia #ADRD #ActaNeuropathologica
doi.org/10.1007/s00401-024-0…
ALT Double immunofluorescence showing TDP-43 (red) and annexin A11 (green) positive aggregates in FTLD-TDP Type C.
Wilfried Rossoll retweeted
Departmental Retreat off to a great start with our Chair @DrNErtekinTaner taking us down memory lane. Wow the last 30 years of research has been productive with a cumulative H-index of 241 and 2,899 papers🤩 Excited for our legendary keynote @DrLiHueiTsai – at Florida, USA
Wilfried Rossoll retweeted
Thank you to all who joined us at #ISMND2024 in Seoul. With over 700 attendees from 19 countries, it was our biggest conference yet! A huge thank you to the organizing committees for their hard work. Special thanks to our main sponsors the @_BrightFocus for their generous support
Wilfried Rossoll retweeted
Absolute highlight was meeting @DrEleanorD during my poster session @ISMND1, straight up fangirling “I’m a fan of your tau interactome papers!” She so kindly responded that she was hoping I’d be by my poster and had stopped by earlier!😬🫣Such a pleasure sharing my work with you!
Wilfried Rossoll retweeted
Congrats to the awardees of the @_BrightFocus Diversity Travel Fellowship Award presented by @PreetiSub - Noah Graves, Linda Lorenz @DrBilalKhalil Lukas Busch, Thi Ai Van Tran, Joshua Gills, Heewon Shin, @ChloeLopezLee @Cara_Croft @jannafur @phdoyleneuro Shivani Aryal #ISMND2024
Wilfried Rossoll retweeted
Closing the session, Wilfried Rossoll @RossollLab @MayoClinicNeuro presents ‘#Proteomics approaches to identify novel modifiers of tau pathology’ #ISMND2024
Wilfried Rossoll retweeted
@MayoClinicNeuro reunites with Mayo alumni at @ISMND1 2024 in Seoul, Korea! What a good looking crew!
@RossollLab @owenaross @jungsukim77 @DrBilalKhalil @dchloechung @Lucyjob2 @HandeKarahan_ @bioinfo_mark @ByungwookKim4 @YJin0715 – at Gangnam-gu, Republic of Korea
Wilfried Rossoll retweeted
α-Synuclein Conformations in Plasma Distinguish Parkinson's Disease from Dementia with Lewy Bodies biorxiv.org/cgi/content/shor… #biorxiv_neursci
Wilfried Rossoll retweeted
So excited to share this! We discuss the role of nuclear-import receptors in controlling and chaperoning phase transitions associated with ALS & FTD. Great collaboration between the @RossollLab & @ShorterLab!
@MolNeuro @alsassociation @PennMedicine @MayoClinicNeuro
'Nuclear-import receptors as gatekeepers of pathological phase transitions in #ALS/#FTD'
@DrBilalKhalil @M_Linsenmeier @neuro_smith @ShorterLab @RossollLab @MayoClinicNeuro @PennMedicine #TDP43
bit.ly/3vMq22t
Wilfried Rossoll retweeted
Nuclear-import receptors as gatekeepers of pathological phase transitions in ALS/FTD, it was great to write this review for @MolNeuro with @DrBilalKhalil @M_Linsenmeier @neuro_smith & @RossollLab! molecularneurodegeneration.b…
Wilfried Rossoll retweeted
The latest publication as part of our 'ALS: Challenges and New Advances' review series!
Find all the exciting reviews in this series here: bit.ly/3WHZ2dC
'Nuclear-import receptors as gatekeepers of pathological phase transitions in #ALS/#FTD'
@DrBilalKhalil @M_Linsenmeier @neuro_smith @ShorterLab @RossollLab @MayoClinicNeuro @PennMedicine #TDP43
bit.ly/3vMq22t