@TNRLab

N^3 (Neuropathologist, Neuroscientist, Nerd), Translational Neuropath Research Laboratory, Co-Director Penn Institute on Aging

 University of Pennsylvania
med.upenn.edu/tnrlab/
Joined December 2011
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【Medicine/Health】 Polyubiquitin May Stabilize Tau Filament Structures in Neurodegenerative Diseases Tau filament stabilization may help explain differences among tau-related neurodegenerative diseases. tsukuba.ac.jp/en/research-ne… doi.org/10.1038/s41594-026-0… #UniversityofTsukuba

Polyubiquitin May Stabilize Tau Filament Structures in Neurodegenerative Diseases | Research News -...

Structure of a pathological tau filament. (Structural data: PDB 10LN / EMDB EMD-75271)Source: https://www.rcsb.org/struc

tsukuba.ac.jp
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What if the stuff attached to tau fibrils affect their pathogenic structure? We found that repositioning polyubiquitin remodels pathological tau filaments, linking PTMs to tau strain biology. Huge credit to Dr. Ryohei Watanabe for leading this work. nature.com/articles/s41594-0…

Repositioning of polyubiquitin alters the pathologic tau filament structure

Nature Structural & Molecular Biology - Watanabe et al. show that tau fibrils from Alzheimer disease and vacuolar tauopathy exhibit distinct seeding patterns in vivo. Cryo-electron microscopy...

nature.com
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Exciting news from the 2026 Tauopathy Challenge Workshop: Four researchers have been awarded a combined $3 million in grants to investigate the structural & thermodynamic properties of tau protein. Read more: prnewswire.com/news-releases… @aging_mind @alzassociation @CurePSP
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Amyloid removal may reduce tau buildup & neurodegeneration in Alzheimer’s disease ft. David Wolk, Christopher Brown (@PennNeurology) & @TNRLab (@PennPathLabMed) @PennMemory tinyurl.com/49ye48ne
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I am so grateful for this outcome, for the incredible colleagues who helped ensure this outcome @PennMedicine @PennNeurology @PennNSG @DanielYoshor @TNRLab, and for the opportunity to share our experience so others can identify and treat this rare neuroinflammatory emergency
Penn Medicine
@PennMedicine17 Sep 2025
31-year-old Shannon Cook was in a month-long coma, diagnosed with a rare, often fatal, brain disorder. Penn Medicine’s bold care decisions helped Cook survive and wake up just in time for Christmas. @PennNeurology spr.ly/6014ArJiy
Family of four sitting on a blanket outdoors in front of evergreen trees, smiling.

ALT Family of four sitting on a blanket outdoors in front of evergreen trees, smiling.

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Ambient air pollution (PM2.5) exposure is associated with increased dementia severity and more advanced Alzheimer's Disease neuropathology found at autopsy. jamanetwork.com/journals/jam…
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There is ample evidence that PM2.5 exposure is harmful to human health. Improving air quality should be considered an investment in public health. It may be expensive, but so is dementia care.
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All of this reflects the amazing work by first author, Boram Kim, and many of my collaborators @PennFTDCenter @PennAging @UPennCEET @PennNeurology @PennPathLabMed
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Maybe my last Tweet? We found that shifting around polyubiquitin (using a chemical biology trick) results in altered #tau filament structure. The unstructured "fuzzy coat" of tau filaments matters!?! #AD #FTD #FTLD #cryoEM #Alzheimer #VCP #raredisease biorxiv.org/content/10.1101/…

Repositioning of polyubiquitin alters the pathologic tau filament structure

Structurally diverse tau filaments form proteinaceous aggregates in a heterogeneous group of neurodegenerative diseases called tauopathies[1][1]. The factors extrinsic to the highly ordered core...

biorxiv.org
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Amazing work by Ryohei Watanabe!
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I've started writing a new grant in anticipation of the RFAs that are coming in 2025. "Synergistic effects of fluorinated water and lecanemab on autism risk in Alzheimer's Disease." 🤮🤯😖☠️
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For my daughter, wife, mother, I #vote.
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.@PennMedicine researchers receive $18M grant from @NIH/@NIHAging to investigate cognitive decline in Lewy body diseases ft. @alicechenp, @drdirwin (@PennNeurology), @TNRLab, Virginia Lee, Kelvin Luk (@PennPathLabMed) & Sharon Xie (@UPennDBEI) tinyurl.com/4u5b3z7c
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You ever meet someone who you know will help change the world just by existing...then you get to know them and see how much they're actively doing to make a #betterworld. Allow me to introduce you to my friend and inspiration for all of our upcoming #MAPT projects, Linde Lee🤩 Kismet brought us together to watch Tim Miller's plenary presentation on tau-targeting therapies for @alzassociation #AAIC24 👉Add her @CureMaptFtd to see how a daughter's love and three sister's passion for finding a cure will be the catalyst the world needs for solving the mysteries of #tau accumulation in the brain. Grateful to @RCFNeuro and @virginiahughes for amplifying her voice. – at Florida, USA
Cure MAPT FTD@CureMaptFtd2 Aug 2024
Incredible trip to #AAIC2024! Thank you to @alzassociation for such an incredible week of learning and connection! Special shoutout to some of our biggest cheerleaders- @DrMariaALZ , @claire_e_sexton, @IgorCamargoF
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Thrilling to give the #AAIC24 introductory plenary about how neuropathology synergizes with other disciplines. Nerve-wracking and exhilirating! Thank u @alzassociation scientific planning committee for giving me the honor of welcoming everyone to Philly. #inclusion #diversity
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