@RossollLab

translational Neuroproteomics Lab | We study protein (dis)aggregation in ALS/FTD, AD, and other neurodegenerative proteinopathies. (Views are my own.)

 Jacksonville,FL
mayo.edu/research/labs/neurobiology-neurodegenerative-diseases/overview
Joined March 2019
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We’re hiring! Two postdoc positions are open in the Translational Neuroproteomics lab at Mayo Clinic Florida, focusing on tau and TDP-43 proteinopathies and neurodegeneration. mayo.edu/research/labs/trans… Apply here: 1) fa-euwp-saasfaprod1.fa.ocs.o… 2) fa-euwp-saasfaprod1.fa.ocs.o… Please share!

Overview - Translational Neuroproteomics - Translational Neuroproteomics Laboratory

Dr. Rossoll's Translational Neuroproteomics Laboratory at Mayo Clinic focuses on new treatments for motor neuron and neurodegenerative disease.

mayo.edu
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It is truly a great honor to be selected as a 2025 Kissick Family Foundation Frontotemporal Dementia (FTD) grantee. I extend my heartfelt gratitude to the Kissick Family Foundation in partnership with @MIPhilanthropy for their support. milkeninstitute.org/content-…

Kissick Family Foundation FTD Grant Program: 2025 Awardees and Projects

In September 2025, the Kissick Family Foundation, in partnership with the Milken Institute Science Philanthropy Accelerator for Research and Collaboration (SPAR

milkeninstitute.org
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In partnership with @aging_mind, @alzassociation, and @CurePSP we recently hosted the 2025 #TauopathyChallengeWorkshop and are excited to announce the grantees who will receive a total of $2.5 million in funding to advance their neurodegenerative research: bit.ly/412dMaN
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It’s truly an honor to be selected as a 2025 #TauopathyChallengeWorkshop grantee. I extend my heartfelt gratitude to the @RCFNeuro, @aging_mind, @alzassociation, and @CurePSP for recognizing the potential impact of our work how TDP-43 co-pathology affects tauopathies.
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molecularneurodegeneration.b… Out now! Probe‑dependent Proximity Profiling (ProPPr) of Phospho‑Tau‑Associated Proteomes across Tauopathies by @DMorderer and @NeuroWren. Great collaboration with @DrNeuroChic and Dr. Dennis Dickson! @MayoClinicNeuro @MolNeuro @cziscience @NIHAging

Probe-dependent Proximity Profiling (ProPPr) Uncovers Similarities and Differences in Phospho-Tau...

Molecular Neurodegeneration - Tauopathies represent a diverse group of neurodegenerative disorders characterized by the abnormal aggregation of the microtubule-associated protein tau. Despite...

link.springer.com
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Our analysis demonstrated that infiltration of APs with FTL-positive microglia is a characteristic feature of CBD pathology. The observed complex co-localization patterns underscore the importance of using fluorescence microscopy to follow up on proximity proteomics findings.
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Our study provides a first comprehensive overview of pTau-associated proteomes across tauopathies and uncovered several important findings. It is also a starting point for further ProPPr projects, where we can put to good use everything that we have learned during this journey.
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Wilfried Rossoll retweeted
Matthew Taliaferro@JMTali3 Mar 2025
Excited to share our latest work! We asked if and how TDP-43 regulates RNA transport in neurons and if this is misregulated in ALS. We found that it works to keep RNAs *out* of neurites, and that loss of TDP-43 activity results in specific RNAs aberrantly accumulating there.
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Wilfried Rossoll retweeted
Matthias Mann Lab@labs_mann14 Jan 2025
Introducing mipDVP (multiplexed imaging-powered Deep Visual Proteomics)! Using 22-marker imaging to profile proteomes across hot/cold tumors, revealing immune microenvironments, macrophage barriers to T cells, & hypoxic adaptations. Out in @MolecularCell doi.org/10.1016/j.molcel.202…
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Wilfried Rossoll retweeted
David Katz@Katz_Lab22 Nov 2024
If Nature and Science journals both agree on this, surely there is at least a 60% chance it is true. nature.com/articles/d41586-0…

‘A place of joy’: why scientists are joining the rush to Bluesky

Nature - Researchers say the social-media platform — an alternative to X — offers more control over the content they see and the people they engage with.

nature.com
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Looks like PPS Silent Surfactant, Progenta anionic acid labile surfactant (AALS) I, AALS II, cationic acid labile surfactant (CALS) I, and CALS II are not commercially available anymore.
Wilfried Rossoll@RossollLab21 Nov 2024
Can someone please point us to a source for mass spectrometry compatible surfactants less pricey than Invitrosol, ProteaseMax, and RapiGest SF? DDM did not work that well in our hands for FFPE tissue extraction and proteomics.
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Can someone please point us to a source for mass spectrometry compatible surfactants less pricey than Invitrosol, ProteaseMax, and RapiGest SF? DDM did not work that well in our hands for FFPE tissue extraction and proteomics.
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Wilfried Rossoll retweeted
Matthew Taliaferro@JMTali13 Nov 2024
Excited to share our latest work! We developed a new method for studying RNA localization via proximity labeling: OINC-seq! In contrast to other proximity methods, labels deposited on RNAs are read directly by sequencing without a need for biotinylation. biorxiv.org/cgi/content/shor…
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