@ReversadeLab

We study #HumanDevelopment #Embryology #Genetics and #RareDisease at @KAUST. Led by Bruno @reversade.

 Saudi Arabia
reversade.com
Joined September 2016
  • Tweets290
  • Following202
  • Followers467
50Media
Reversade Lab retweeted
AJHG@AJHGNews2 Jan 2025
📢New today! 📰CIROZ is dispensable in ancestral vertebrates but essential for left-right patterning in humans 🧑‍🤝‍🧑@reversadelab & colleagues cell.com/ajhg/abstract/S0002…
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Online! A progeroid syndrome caused by a deep intronic variant in TAPT1 is revealed by RNA/SI-NET sequencing. #progeroid_syndrome By A. Mayer, B. Reversade & colleagues @ReversadeLab @mayer_lab 🗞️#openaccess: doi.org/10.15252/emmm.202216…
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Handmade time-lapse of zebrafish development. Credit to @andro_pantru. #ZebrafishZunday
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"In the present manuscript, Wong et al describe for the first time the human phenotype resulting from the bi-allelic germline T543M mutation in the RAF1 proto-oncogene. " Rev #1
Review Commons@ReviewCommons15 Nov 2022
"<i>A</i> Progeroid Syndrome Caused <i>by RAF1</i> deficiency Underscores the importance of RTK signaling for Human Development" #RefereedPreprint Samantha Wong, @ReversadeLab et al medrxiv.org/content/10.1101/…
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Reversade Lab retweeted
medRxiv@medrxivpreprint21 Jul 2022
Deciphering the consequence of deep intronic variants: a progeroid syndrome caused by a TAPT1 mutation is revealed by combined RNA/SI-NET sequencing medrxiv.org/cgi/content/shor… #medRxiv
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New work from @Wagnerlab_RNA and @ReversadeLab just out in @NatureComms 👇 Mutations in INTS13 cause a ciliopathy and disrupt Integrator module interactions; the findings underscore the importance of Integrator to human development urmc.info/y2 #URochesterResearch
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My thesis work is out now in Nature Communications! The #IntegratorComplex is destabilized by rare mutations in INTS13. This change in Integrator function leads to upregulation of a set of ciliary genes, causing a #ciliopathy in 4 individuals nature.com/articles/s41467-0…
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Reversade Lab retweeted
Jason Spence@TheSpenceLab8 Jun 2022
Huge congrats to @UMCDB PhD student @ReneeConway and team (@joshhwu @tristanfrum @_Alyssa_J_ and collaborators)! R-SPONDIN2+ mesenchymal cells form the bud tip progenitor niche during human lung development, in @Dev_Cell cell.com/developmental-cell/… #organoids
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Reversade Lab retweeted
Development@Dev_journal4 Oct 2022
Omics profiling identifies the regulatory functions of the MAPK/ERK pathway in nephron progenitor metabolism An #OpenAccess Research Article from Hyuk Nam Kwon, Kristen Kurtzeborn, Satu Kuure @shkuure and colleagues journals.biologists.com/dev/…
Control and Pycr1/2 double-knockout kidneys immunostained with cadherin 6 (CDH6, white), and calbindin (CALB, green).

ALT Control and Pycr1/2 double-knockout kidneys immunostained with cadherin 6 (CDH6, white), and calbindin (CALB, green).

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Early Embryogenesis and Epiegenetics (EEE) conference @WeizmannScience February 2023- Registration and abstract submission are now open. Will be great fun and many short talks to be selected from submitted abstracts. weizmann.ac.il/conferences/e…
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Great exchange between two large-scale national projects @QatarGenome & Precision Health Research Program #PRECISE #Singapore during #PMFG2022 , to advance health &clinical breakthroughs in both countries
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Tune in to radio CNA938's Health Matters with Daniel Martin tomorrow, 23 August, at 4:10pm for Prof Bruno Reversade's interview on FOCAD. Read more: a-star.edu.sg/gis/news-event…
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After lunch more exciting science and #diseasemodeling by @ReversadeLab on novel heterotaxy genes characterization!
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Reversade Lab retweeted
Shifeng Xue@shifengxue24 Jun 2022
Happy to share our latest work on the role of maternal SMCHD1 in regulating #HOX expression @NatureComms with @ReversadeLab @MathuruLab. This project survived a job change, maternity and pandemic. 🧵 nature.com/articles/s41467-0… 1/n

HOX epimutations driven by maternal SMCHD1/LRIF1 haploinsufficiency trigger homeotic transformati...

Nature Communications - Hox genes are known to control anteroposterior patterning, including the vertebrate spine. Here Xue et al. show that maternal Smchd1 regulates Hox expression in an...

nature.com
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Nanopore sequencing is coupled with machine learning models to directly identify A-to-I edits in RNA molecules from the characteristic reads. @MengHowTan1 nature.com/articles/s41592-0…
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Great session on left/right patterning at #ESHG2022 including talk by Bruno Reversade showing the role of CIROP in heterotaxia. More here 👇on its evo-devo discovered
Reversade Lab@ReversadeLab14 Dec 2021
Excited to share our latest collaborative work @NatureGenet: we find a genetic module of 5 genes essential for Left-Right asymmetry in humans and other vertebrates dependent on motile-cilia in their L-R Organizers. Spearheaded by Emma Szenker-Ravi. (1/6) nature.com/articles/s41588-0…
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🎇 ICYMI #RareDiseaseDay2022 @NatureGenet 📰 Discovery of a genetic module essential for assigning left–right asymmetry in humans and ancestral vertebrates 🧑🏾‍🤝‍🧑🏼 @ReversadeLab Emmanuelle Szenker-Ravi, Martin Blum, Patrice Bouvagnet, and team ⬇️ go.nature.com/3HsU9fe

Discovery of a genetic module essential for assigning left–right asymmetry in humans and ancestral...

Nature Genetics - Phylogenomic and genetic analyses identify an ancestral module of genes expressed specifically in ciliated left–right organizer tissue and required for left–right axis...

nature.com
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🚨Online now @NatureGenet ⬅️🧬➡️ Discovery of a genetic module essential for assigning left–right asymmetry in humans and ancestral vertebrates ✍️🏻@ReversadeLab Emmanuelle Szenker-Ravi, Patrice Bouvagnet, and team 👇🏻👇🏼👇🏾 go.nature.com/3lWFnpl
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Reversade Lab retweeted
Javier Santoyo@jsantoyo27 Nov 2021
The dark proteome: translation from noncanonical open reading frames. #NonCanonicalORFs #Translatome cell.com/trends/cell-biology… @TrendsCellBio

The dark proteome: translation from noncanonical open reading frames

Omics-based technologies have revolutionized our understanding of the coding potential of the genome. In particular, these studies revealed widespread unannotated open reading frames (ORFs) through...

cell.com
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A paper in @NatureComms suggests that identical twins have a specific epigenetic signature in their DNA that persists from conception to adulthood. The finding provides insights into the biology surrounding identical twin conception. go.nature.com/3D1WY5k
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