The question that drives our research @yalenus is to gain a better understanding of how #brains operate and generate #behavior; #mechanisms.
At E6, Yale-NUS labs
Joined April 2020
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Happy to announce our recent study on “Evaluating the inter-species transmission risk of amyloid beta peptide aggregates via ingestion” came online over the weekend.
rdcu.be/dKeoU
Ajay Mathuru retweeted
Our new manuscript describing gene multiplexing (using RAM-FISH) is finally out... We profiled multiple known and novel mRNA candidates during different developmental stages of Bicyclus and Danio. biorxiv.org/content/10.1101/… @MonteiroLab @MathuruLab
chrna3 modulates biphasic response to alcohol biorxiv.org/content/10.1101/…
Our preprint on biphasic response to alcohol and the nicotinic acetylcholine receptor subunit chrna3 is out! The lay summary of our findings in the thread below.
However, chrna3 mutants exhibited a prolonged attraction to alcohol and were less affected by alcohol exposure. These findings suggest that chrna3 dysfunction may contribute to acute alcohol tolerance, potentially playing a significant role in the development of addiction.
And, a big thank you to a fantastic ongoing collaboration with @TirthaDasBaner1 and Antónia Monteiro, on a number of projects. The spatial expression patterns studied uses a modified HCR tech perfected in-house allowing for expression analyzing in 2-3 week old z.🐟!
However, we conclude we need more research to fully ascertain if iatrogenic transmission by this route is possible when the Aβ sequence similarity between species is higher than it is between zebrafish and humans or there is a long incubation period.
Great to see what started out as a fun little 💬 with @jangruber467 and @ nicktolwinski a few years ago matured into the HLCA catalyst award and this paper! Congratulations to @ Josh Raine, on his first paper in the lab!
Evaluating the transmission risk of amyloid beta peptide via ingestion biorxiv.org/content/10.1101/…
The answer at the moment, thankfully, seems to be unlikely!
Read more ⬆️
Ajay Mathuru retweeted
📢New paper out in #PNAS on mitochondrial control of microglial phagocytosis.
🧵A brief thread
pnas.org/doi/10.1073/pnas.22…
@PNASnews @NTU_LKCMedicine @NTUsg @alzforum
#mitochondria #microglia #Alzheimers #Immunometabolism
Check out the smchd1 story here. nature.com/articles/s41467-0…
Had not been thinking about homeotic transformations till this amazing study with @shifengxue and @ReversadeLab.
Congratulations 🎉 also to Raunak Vijayakar whose capstone thesis contributed to this publication. His 1st 📝!
Ajay Mathuru retweeted
Happy to share our latest work on the role of maternal SMCHD1 in regulating #HOX expression @NatureComms with @ReversadeLab @MathuruLab. This project survived a job change, maternity and pandemic. 🧵 nature.com/articles/s41467-0… 1/n
Hi all,
We are hiring! My lab has two open positions. Please write to me with the job title in subject line. Details here - yale-nus.edu.sg/careers/rese…
And here -
yale-nus.edu.sg/careers/rese…
#zebrafishjobs
Have you been wondering what fish will do if they could self-administer alcohol? Check out our lab's preprint for an answer! #Hormesis, #CRITTA with at James, and @adamcchang. Contingent-behavior assay shows zebrafish preference for alcohol is biphasic biorxiv.org/content/10.1101/…
Great to see this work in pre-print! congrats @ Anja and @ Erin
Connect with me at Mathurulab for these mutants.
Oxytocin receptors influence the development and maintenance of social behavior in zebrafish (Danio rerio) biorxiv.org/content/10.1101/…
Fantastic to see this published. Great #Collaboration with IMH, NAMS, and Venki‘s lab @ IMCB on an important problem. #Mentalhealth
“Whole-Exome Sequencing to Identify Potential Genetic Risk in Substance Use Disorders…”
mdpi.com/1165130, @JCM_MDPI
Whole-Exome Sequencing to Identify Potential Genetic Risk in Substance Use Disorders: A Pilot Feasibility Study mdpi.com/1165130 ##mdpijcm via @JCM_MDPI
