@ReikLab

Twitter feed for the laboratory of Prof. Wolf Reik @BabrahamInst and @altos_labs Cambridge Institute of Science. Tweets by lab members and views are our own.

 Cambridge, UK
babraham.ac.uk/our-research/epigenetics/wolf-reik
Joined April 2013
  • Tweets1.5K
  • Following522
  • Followers4.9K
88Media
The product of a large and exciting international collaboration! Our study investigating the consequences of the endocrine disruptors DDT/ DDE on the sperm epigenome of Greenlandic Inuit and South African VhaVenda men is finally out. ehp.niehs.nih.gov/doi/10.128…
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Very excited to share that our work reconstructing chromothripsis has now been published in @CellGenomics! We reconstructed chromosomes with up to 800 rearrangements on a single allele and queried epigenetic and transcriptomic consequences. Thread below! cell.com/cell-genomics/fullt…

Haplotype-specific assembly of shattered chromosomes in esophageal adenocarcinomas

Ijaz et al. reconstructed chromothriptic and wild-type chromosomes in patient-derived esophageal adenocarcinoma organoids using a haplotype-aware method. Upon these assemblies, they layered epigene...

cell.com
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My main PhD work is now out as a preprint 👇
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In our latest publication, we recapitulated features of early human #development and characterised the #epigenetic landscape of naive and primed hPSCs in vitro. We found that X chromosome erosion is reversed by resetting and subsequent hPSCs capacitation: science.org/doi/full/10.1126…
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Excited for the pre-print of our latest work to go public! In this study, we discovered that DNA damage tolerance is required for mammalian primordial germ cell DNA demethylation and development biorxiv.org/content/10.1101/… Fantastic collaboration with @ReikLab @HGLeitch 1/9

Primordial germ cell DNA demethylation and development require DNA translesion synthesis

Mutations in DNA damage response (DDR) factors are associated with human infertility, which affects up to 15% of the population. It remains unclear if the role of DDR is solely in meiosis. One...

biorxiv.org
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Please RT! We have a position for a Research Associate/Senior Research Associate to work on chromatin mechanics in cellular ageing and rejuvenation. @ReikLab; @altos_labs boards.greenhouse.io/altosla…

Altos Labs

job-boards.greenhouse.io
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Happy to share our News and Views article on a new enzymatic 5mC sequencing method by @KohliLab and colleagues out in @nchembio. @ReikLab; @altos nature.com/articles/s41589-0… and the original article: nature.com/articles/s41589-0…
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Delighted to see this review out! cell.com/trends/molecular-me… Jan Vijg, @schumacherbj, @_MichaelAntonov, Chris Bradley, @ATJCagan, @geochurch, @gladyshev_lab, Vera Gorbunova, Alexander Maslov, @ReikLab,@altos_labs, Samim Sharifi, Yousin Suh, Kenneth Walsh

Mitigating age-related somatic mutation burden

Mutations are alterations in genetic information and the ultimate source of biological variation, fueling evolution by natural selection. Driven by DNA damage (see Glossary) (Box 1), mutations are...

cell.com
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What began as a few concept being kicked around in stimulating & memorable discussions, progressed into a comprehensive piece on paternal epigenetic inheritance. I am very excited to share @KimminsSarah and I’s Perspective out today in @NatureComms! doi.org/10.1038/s41467-023-3…

Emerging evidence that the mammalian sperm epigenome serves as a template for embryo development

Nature Communications - Increasing evidence suggests parental environmental stressors can influence offspring health and disease outcomes. In this perspective, the authors provide an update of the...

nature.com
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Replying to @ReikLab
@ReikLab reunion!! This is sooo exciting!! (@marioiurlaro seems to agree with this statement, if you can spot him).
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Exciting science is being presented at #AGBT. Swing by poster 414 to learn how @aledjohnparry @Diljeet_Gill and @ReikLab are using our tech to profile #genetic and #epigenetic changes, at read-level, after cellular rejuvenation.
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A long time in the making – but I am very happy to see our collaborative effort with @penningerlab @IMBA_Vienna finally published in @EMBOMolMed “A whole-genome scan for Artemisinin cytotoxicity reveals a novel therapy for human brain tumors” doi.org/10.15252/emmm.202216…

A whole‐genome scan for Artemisinin cytotoxicity reveals a novel therapy for human brain tumors

EMBO Molecular Medicine - The natural compound Artemisinin is the most widely used antimalarial drug worldwide. Based on its cytotoxicity, it is also used for anticancer therapy. Artemisinin and...

link.springer.com
EMBO Mol. Medicine@EmboMolMed6 Feb 2023
Happy Monday! 🙂 Online today: A whole-genome scan for #Artemisinin cytotoxicity reveals a novel therapy for human #BrainTumors By J. Taubenschmid-Stowers, JM Penninger & colleagues @IMBA_Vienna @UBC 🗞️Read #openaccess: doi.org/10.15252/emmm.202216…
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We are thrilled that our new paper has been published by @Nature. In it, we explain how our novel pre-sequencing workflow and analysis software enables the ability to interrogate genetics and DNA #epigenetics in a single workflow Read the full paper 👉 nature.com/articles/s41587-0…
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Do all cells age the same? At least not by DNA methylation age: Single cell DNA methylation ageing in mouse blood biorxiv.org/cgi/content/shor… #bioRxiv. Wonderful collaboration between @mjbonder @ReikLab @OliverStegle @vonmeyenn_lab & @rulandsgroup!
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Excited to see our latest work published @Dev_journal where we explored the function and evolution of NANOG's pseudogenes. Huge congratulations to Kate Maskalenka and @gokberkalagoz for leading the work, together with @aylwyn_scally and colleagues! 🎉 journals.biologists.com/dev/…

NANOGP1, a tandem duplicate of NANOG, exhibits partial functional conservation in human naïve...

Highlighted Article: Establishing that NANOGP1 has retained partial functional conservation with its ancestral copy NANOG sheds light on the role of gene duplication and subfunctionalisation in human...

journals.biologists.com
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Meet our first keynote speaker for #interact2023! 👇 🧬 Dr. Wolf Reik is the Director of the Altos Labs Cambridge Institute, honorary group leader at the Babraham Institute and honorary professor of epigenetics at the University of Cambridge. @reikwolf @reiklab @altoslab
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We are looking for a postdoc to join our team @BabrahamInst, to work on a project investigating gene regulatory mechanisms in human early development. For more info and to apply: babrahaminstitute.livevacanc… Please help us to spread the word.
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Look who's on the cover!
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How primitive social organisation of wasps achieve specialization (division of labour) but retain plasticity to adapt to environmental changes? We went for multidisciplinary and multi-scale approaches to bring some answers … 🧵 (1/7) cell.com/cell-systems/fullte…
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New paper out: With @ReikLab and @SolennPatalano we studied physical mechanisms of how societies of paper wasps can maintain stable social order (queen and workers) but show striking plasticity by rapidly reprogramming after loss of the queen👇 @csbdresden sciencedirect.com/science/ar…
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