Twitter feed for the laboratory of Prof. Wolf Reik @BabrahamInst and @altos_labs Cambridge Institute of Science. Tweets by lab members and views are our own.
Cambridge, UK
Joined April 2013
- Tweets1.5K
- Following522
- Followers4.9K
- Likes2.4K
Pinned Tweet
The Reik Lab are excited to join Altos Labs - whose launch was announced today prn.to/3FBwEzH - to work on cellular rejuvenation programming, whilst continuing to work with our wonderful community @BabrahamInst
Curious about the seemingly contradictory functions of m6A in R-loops? Check out this comment by @a_abakir & @AlexeyRuzov out in @NatureGenet where they propose a new model for a dual function of m6A in R-loop regulation. nature.com/articles/s41588-0…
Preprint alert! 🎉 @C_D_Todd and the team used multi-omic profiling of human and mouse embryonic development to identify a conserved program of epigenetic priming at lineage specific enhancers for all three germ layers within the epiblast.
biorxiv.org/cgi/content/shor…
Finally, we epigenetically profiled a collection of genetically diverse hiPSCs to identify sequence determinants and candidate transcription factors that may be responsible for establishing the primed enhancer state at key enhancers for human neural development.
A colossal thank you to this collaborative group: @sciencejannat, @Feriitrb, @ODovgusha, @RArgelaguet, @j_e_pearce, @ikafetzo, @AliceSantam, @guenesdoganlab, @stefanschoenfe1 and others!!
Check out Wolf speaking at the recent @codexworld Top 50 Innovators event! 🧪
youtu.be/KPzCXAmSeR8?si=pf1p…
#T50 #CodexTalks
Reik Lab retweeted
The product of a large and exciting international collaboration! Our study investigating the consequences of the endocrine disruptors DDT/ DDE on the sperm epigenome of Greenlandic Inuit and South African VhaVenda men is finally out.
ehp.niehs.nih.gov/doi/10.128…
Need a podcast for your commute or for cell culture? 🎧Check out Wolf, @METorresPadilla and @Boyan84 discussing epigenetic regulation in development, ageing and rejuvenation as part of the @PioneerCampus Podcast! 👇
Welcome to the newest episode of @PioneerCampus #Podcast
@METorresPadilla @Boyan84 from @HelmholtzMunich discuss with Wolf Reik @altos_labs Cambridge #Epigenetics from organ #development to #regenerative #medicine
podcasts.apple.com/de/podcas…
Reik Lab retweeted
Very excited to share that our work reconstructing chromothripsis has now been published in @CellGenomics! We reconstructed chromosomes with up to 800 rearrangements on a single allele and queried epigenetic and transcriptomic consequences. Thread below!
cell.com/cell-genomics/fullt…
Single cell multi-omics (scNMT-seq) showed reduced chromatin accessibility and disrupted nucleosome positioning at ZGA genes. This suggests a novel link between the maternally deposited chromatin remodeller SMARCA5 and transcription initiation in mammalian embryos.
Preprint alert 🎉🐁👩🔬🧬! @OanaKubinyecz used Trim Away to deplete SMARCA5 in mouse zygotes and found that in its absence major ZGA is impaired in 2-cell embryos. biorxiv.org/content/10.1101/…
Reik Lab retweeted
In our latest publication, we recapitulated features of early human #development and characterised the #epigenetic landscape of naive and primed hPSCs in vitro. We found that X chromosome erosion is reversed by resetting and subsequent hPSCs capacitation: science.org/doi/full/10.1126…
Reik Lab retweeted
Excited for the pre-print of our latest work to go public! In this study, we discovered that DNA damage tolerance is required for mammalian primordial germ cell DNA demethylation and development biorxiv.org/content/10.1101/…
Fantastic collaboration with @ReikLab @HGLeitch 1/9
Reik Lab retweeted
Please RT!
We have a position for a Research Associate/Senior Research Associate to work on chromatin mechanics in cellular ageing and rejuvenation. @ReikLab; @altos_labs
boards.greenhouse.io/altosla…
Job alert 🚨
We're looking for a Research Associate/Senior Research Associate to work with us on chromatin mechanics in the context of cellular ageing and rejuvenation.
More details here 👇
boards.greenhouse.io/altosla…
Reik Lab retweeted
Happy to share our News and Views article on a new enzymatic 5mC sequencing method by @KohliLab and colleagues out in @nchembio. @ReikLab; @altos
nature.com/articles/s41589-0…
and the original article:
nature.com/articles/s41589-0…
Lab members are having a great time at #ISSCR2023, despite getting a bit soggy in an unexpected storm!
@AliceSantam @ikafetzo @BrendanTerry8
