molecular mechanisms of cell fate specification in development and disease; molecular glues and induced protein degradation as new therapeutic options
Berkeley, CA
Joined January 2015
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Rapé Lab retweeted
#LungCancerAwarenessMonth reminds us why our mission matters, innovation saves lives. Our novel CBL-B inhibitor NX-1607 aims to deliver new hope and improved outcomes for people affected by solid tumors including #lungcancer.
Learn more about our work: bit.ly/3L7kMKK
Rapé Lab retweeted
Nurix’s CSO, Gwenn Hansen, Ph.D., will discuss the development of novel BTK degrader bexobrutideg (NX-5948) in a presentation at the 8th Annual TPD & Induced Proximity Summit on Tues, Oct 28, 2025, at 12:15 a.m. ET.
Learn more here:
bit.ly/4gLjPXN
#TPDSummit2025
Rapé Lab retweeted
Check out the Stanford.Berkeley.UCSF Next Generation Faculty Symposium highlighting the work of exceptional early-career scientists in the broad field of quantitative biological and biomedical sciences:
Wednesday, Sept. 10th 2025 9:30AM - 1:45PM (PT):
czbiohub.zoom.us/webinar/reg…
ALT 2025 Next Generation Faculty Symposium registration flyer: https://czbiohub.zoom.us/webinar/register/WN_I5xR9QzZR7u0hfbHYXD8EA
Rapé Lab retweeted
🔬 The Future of Biotech is Female… and It’s Global.
We just wrapped a strategic advisory with international female founders in life sciences; winners of the @dwih_sf sponsored 8-week entrepreneurship program hosted by The GUILD.
They’re innovating across cancer, clinical trials, and sustainability, and they came to the Bay Area ready to scale 🌉
#WomenInSTEM #MolecularTherapeutics #DWIH #TheGUILD #BiotechFounders #MTI #MolecularTherapeuticsInitiative
Rapé Lab retweeted
Today on #WorldCLLDay, we join the global community in raising awareness of #CLL. At $NRIX, we’re advancing bexobrutideg (NX-5948), our BTK degrader, with the goal of transforming outcomes and bringing new hope to patients. Learn more about #CLL here: wclld.org/
Rapé Lab retweeted
Check out this recap of Berkeley's recent inaugural Bay Area Biotech Day which brought communities together to foster collaboration & accelerate the translation of cutting-edge biological discoveries into life-changing therapeutics! 🧪 @MTI_UCB
mcb.berkeley.edu/news-and-ev…
ALT Keynote speaker Dr. Carolyn Bertozzi at the Bay Area Biotech Day. Photo credit: Serim Yang.
Rapé Lab retweeted
We're Hiring! Assistant Professor of Molecular Therapeutics in MCB. Learn more and apply online: aprecruit.berkeley.edu/JPF05…
Rapé Lab retweeted
Tenure track position alert! Assistant Professor of Molecular Therapeutics in MCB @UCBerkeley. Apply and come be our colleague! 🎉
aprecruit.berkeley.edu/JPF05…
Rapé Lab retweeted
📣 @UCBerkeley PIs: IGI & AditumBio have launched the IGI Incubator Program - offering grants of $200-400K + expert mentoring for novel therapeutics & discovery platform technologies. 2–3-page proposals due Sept 15 2025.
Apply: innovativegenomics.org/igi-i…
#Biotech #UCBerkeley
Rapé Lab retweeted
It was great to join Bay Area Biotech Day at UC Berkeley to share updates from our protein degradation pipeline, including our work with DACs, DEL-AI, machine learning driven discovery & CNS-penetrant BTK degraders.
Thanks to our team for the great presentations!
#BiotechDay
Rapé Lab retweeted
$NRIX’s VP of DEL & Protein Sciences Jose Santos, Ph.D., will discuss using $NRIX’s DEL-AI Platform to accelerate the discovery & development of protein degraders at the 3rd Targeted Protein Degradation Conference in Japan on Wed, Jul 30 at 1:15 p.m. JST. bit.ly/4jYXBBL xitter.cf/Nurix_Tx/status/194984…
Rapé Lab retweeted
Nurix’s Assoc. Dir. of DEL Screening Marie Lynne Malone, Ph.D., will discuss the use of DEL to develop targeted protein degradation therapies at the Gordon Research Conference on Tues, Jul 29, 2025, at 8:30 a.m. ET. Learn more: bit.ly/4kLqRgm
Rapé Lab retweeted
It’s great to see our @RapeLab paper being highlighted @CellChemBiol . Thank you @LanderLab for your comments!!
Silencing stress: Structural insights into ISR termination by the SIFI ubiquitin ligase dlvr.it/TM03Rt
Rapé Lab retweeted
New preprint w/ the Dupage lab! FSP1 KO in Tregs / Tcells promotes tumor suppression, highlighting the therapeutic value & single-agent potential of FSP1 inhibition. A new paradigm for targeting ferroptosis in the immune system (not just in cancer cells).
biorxiv.org/content/10.1101/…
Rapé Lab retweeted
A new #CRISPR Cures center, funded by $20M from @czi and led by @UrnovFyodor, will create 8 custom therapies for patients in the next 3 years. “Our goal is to aggressively walk the walk of CRISPR platformization,” Urnov told me. More in @endpts: endpoints.news/crispr-cures-…
Rapé Lab retweeted
UC Berkeley isn’t just the No. 1 public research university in the nation — it’s a force for the public good.
Every discovery we make is built to serve society, from confronting climate change and improving access to clean drinking water to advancing cancer treatments and driving equity across communities.
Rapé Lab retweeted
This paper now published in @ACSCentSci!!
pubs.acs.org/doi/10.1021/acs…
Excited to highlight our latest @biorxivpreprint by graduate student @L__Orreo on the discovery of a covalent degradative handle that acts through two unique cysteines C173 and C178, on the frequent-hitting E3 ligase DCAF16 that can be used to modularly design monovalent and bifunctional degraders, even against the truncation variant of the androgen receptor AR-V7. Thanks to @OlzmannLab for the great collaboration, and also thanks to @NovartisScience @TheMarkFdn @MTI_UCB @UCB_Chemistry @berkeleyMCB! (1/3) biorxiv.org/content/10.1101/…
Rapé Lab retweeted
I'm honored to have been selected as a JCC postdoctoral Fellow. This will support my research in elucidating the detailed molecular mechanisms of UPR.
Huge thanks to my advisors @RapeLab @aliceyting, and collaborators/colleagues for their support!
jccfund.org/blog/the-jane-co…
Rapé Lab retweeted
Congrats to MCB postdocs Aurora Alvarez-Buylla (Schepartz Lab), Grace Hibshman (Nogales Lab) and Heegwang Roh (Rapé Lab) for being selected as 2025 Jane Coffin Childs Fellows! 🎉👏 @schepartzlab @NogalesLab @RapeLab @heegwangroh
jccfund.org/fellows/class-of…
Rapé Lab retweeted
URGENT call to action: please contact any Republican senator you know to keep ORPHAN Cures Act & Accelerating Access for Kids Act in the reconciliation bill - at high risk of being removed @IAmBiotech #BIO2025