Rest in peace, David Baltimore. Dr. David Baltimore, Nobel Prize–winning biologist, was one of the most influential scientists of our time. His work reshaped modern molecular biology and immunology, altering our understanding of viruses and immune responses and laying the foundation for advancements in gene therapy, cancer research, and vaccine development. His influence extended far beyond the lab: through his leadership at major research institutions and his guidance of scientific inquiry, he helped shape the very landscape of modern biology. I photographed Dr. Baltimore on November 2, 2021, at Caltech’s Athenaeum, a setting befitting his legacy. Our conversation was wide-ranging, touching on molecular biology, the evolving challenges of university administration, and the responsibilities of scientific leadership in a rapidly changing world. His insights carried the weight of experience, tempered by a continued passion for discovery and mentorship. We sat for portraits beneath his own painted likeness in the Athenaeum, a moment that highlighted his enduring impact. Later, in the shadowed reading room, surrounded by art and the quiet weight of history, his presence felt both scholarly and deeply reflective. The setting underscored not just his scientific contributions but also his role as a custodian of knowledge, someone who expanded the frontiers of biology and ensured that those who followed would have the tools and guidance to push them further. Dr. Baltimore’s contributions to virology and immunology will remain central to the foundations of modern biomedical science. His leadership at Caltech and beyond influenced generations of researchers, making him a pivotal figure in both scientific discovery and institutional stewardship. His life’s work is a reminder that science is both a pursuit of knowledge and a responsibility, one that demands vision, integrity, and a commitment to the generations that inherit its discoveries. explorers.com/david-baltimor… @theNASEM @NobelPrize @theNASciences @Caltech

Silencing stress: Structural insights into ISR termination by the SIFI ubiquitin ligase dlvr.it/TM03Rt

‘For pioneering innovative strategies to overcome viral defenses through novel antibody-focused approaches.’: Pamela Bjorkman, Wolf Prize Laureate in Medicine 2025, has revolutionized our approach to viral defense with her novel, antibody-focused strategies. Join us in celebrating her groundbreaking impact! @Caltech #Medicine #wolfprize2025 #wolfprizelaureate #wp2025medicine #wp2025

Very excited to present the structural and mechanistic basis for stress response silencing by the monster E3 ligase SIFI. biorxiv.org/content/10.1101/…

Jensen (Jen-Hsun) Huang, Founder and CEO of @nvidia will deliver the keynote address at Caltech's 130th Annual Commencement Ceremony on June 14, 2024. caltech.edu/about/news/nvidi…

🔬 Exciting findings in our latest publication out in @nature! This work delves into the dynamic world of HIV-1 envelope structures, revealing distinct conformational changes during host receptor (CD4) engagement. 🧬💡