Michael Rauh retweeted
Our latest work, uncovering the origins of microglia in human aging! Link to article below
👇
Gaining therapeutic access to the human brain is one of the biggest unsolved problems in biomedical science.
Today @nature, we uncover a massive influx of immune cells into the human brain during aging, revealing that the brain is more accessible than previously thought. 1/
nature.com/articles/s41586-0…
Michael Rauh retweeted
Gaining therapeutic access to the human brain is one of the biggest unsolved problems in biomedical science.
Today @nature, we uncover a massive influx of immune cells into the human brain during aging, revealing that the brain is more accessible than previously thought. 1/
nature.com/articles/s41586-0…
Michael Rauh retweeted
It's been a while now, but @DrFlashHeart and I are excited to share that our work exploring somatic gene x environment interactions between CHIP and air pollution in lung cancer is now published in @JNCI_Now
doi.org/10.1093/jnci/djag159
Air pollution is a recently recognized driver of lung cancer among never-smokers.
In a new preprint, we show that clonal hematopoiesis of indeterminate potential (CHIP) and PM2.5 form a novel gene × environment interaction promoting NSCLC tumorigenesis.
medrxiv.org/content/10.1101/…
Michael Rauh retweeted
✨ Thrilled to share our new publication in Nature.
We define an “inflammatory memory” HSC state (HSC‑iM), linking lifelong inflammatory exposure to aging and disease.
📄 Article: nature.com/articles/s41586-0…
Grateful to an incredible team and global collaborators 💚💙
Michael Rauh retweeted
Very nice CH review series in Hematologica.
haematologica.org/issue/view…
Michael Rauh retweeted
📢 Our review on clonal hematopoiesis + evolutionary dynamics using mathematics is now available online @NatureGenet Check it out! #CHIPsm
Modeling the evolutionary dynamics of clonal hematopoiesis -- @S_Marzban et al, Nature Genetics
rdcu.be/e4cP1
Michael Rauh retweeted
Happy International Day of Women & Girls in Science! 🌟 Celebrating the brilliant minds breaking barriers, sparking innovation, & inspiring future generations to dream bigger. Here’s to curiosity, discovery, and the power of science! 💡🔬 #WomenInScience #GirlsInSTEM #IDWGS2026
Michael Rauh retweeted
CHIP ahoy: charting a decade of discovery in clonal hematopoiesis | Haematologica haematologica.org/article/vi…
Michael Rauh retweeted
@rheumrob,@AlexBickMDPhD, & I are excited to share that our work is now out in @jclinicalinvest! CHIP epi studies underestimate the association between CHIP & disease using WGS vs deep sequencing. Many thanks to the co-authors, participants, & reviewers! doi.org/10.1172/JCI198861
Using a unique cohort of 10k doubly sequenced people in @VUMCDiscoveries's BioVU, @AlexBickMDPhD, @yash_pershad, and I investigated how well #WGS data really works for detecting #CHIP. medrxiv.org/content/10.1101/…. Thread below! 1/n
Michael Rauh retweeted
CHIP was associated with increased heart failure and ischemic cardiovascular disease risk after #cancer therapy in patients with solid tumors, especially among those with higher #chemotherapy exposure. ja.ma/3Nj5vuW
Michael Rauh retweeted
Clonal hematopoiesis driven by Dnmt3a mutations promotes metabolic disease development in mice
In this Research Letter, Bowen Yan @BowenyanYan, Olga A. Guryanova @gur_ola @UFHealthCancer @UF_Pharmacolo& team @UFMedicine report #ClonalHematopoiesis, an #aging related condition caused by mutations in the #blood system, promotes #obesity, and drives the risk of #diabetes and #MASLD in the context of a high-fat #diet: doi.org/10.1172/JCI197100
Michael Rauh retweeted
📢 Online today: Ancestry-dependent patterns of somatic mosaicism and clonal hematopoiesis mutations in over 125,000 individuals reveal distinct cancer associations rdcu.be/eSROU. A huge feat with pretty figures, driven by #ChristelleColinLeitzinger. 👏
🚨🚨 Our new manuscript is now available online!
Co-led with the awesome @mingxiangteng
Peripheral blood somatic mosaicism and clonal hematopoiesis across ancestry backgrounds medrxiv.org/content/10.1101/…
Michael Rauh retweeted
Happy to share that our work on TET2 CH in ICI therapy is now out in @CR_AACR!
We found that TET2 mutations promote myeloid co-stimulatory programs and suppress T cell exhaustion, contributing to improved immunotherapy response!
🔗Read more here: doi.org/10.1158/0008-5472.CA…
Michael Rauh retweeted
CHIP variants are often discovered incidentally in liquid biopsy testing, but is plasma cell-free DNA reliable when CHIP variants are the desired finding? 🩸@BloodAdvances @AlexBickMDPhD 🧵1/12
Michael Rauh retweeted
Congratulations to @PMResearch_UHN's Dr. Robert Vanner, who leads a team awarded $1M through @BrainCanada and @SRC_CRS's 2025 Translational Research Grant in Brain Cancer! 🎉
🔗Learn more about the project focused on advancing #glioblastoma research: braincanada.ca/funded_grants…
🚨 Big news in #braincancer research! Brain Canada & @SRC_CRS are funding 2 top teams: Dr. Robert Vanner & Dr. Sheila Singh with $1M each over 3 years.
@CDCR_Mac @UnityHealthTO
Read more ➡️ braincanada.ca/announcements…
Michael Rauh retweeted
🚨 Big news in #braincancer research! Brain Canada & @SRC_CRS are funding 2 top teams: Dr. Robert Vanner & Dr. Sheila Singh with $1M each over 3 years.
@CDCR_Mac @UnityHealthTO
Read more ➡️ braincanada.ca/announcements…
Michael Rauh retweeted
Drs. Caitlyn Vlasschaert @DrFlashHeart & Michael Rauh @QMyPath (@QueensuDOM)'s study on assessing the role of clonal hematopoiesis in respiratory infection risk and vaccine responses in the elderly: psifoundation.org/funded-res… #NationalSeniorsDay
Michael Rauh retweeted
Primary Prevention of colon cancer. We don't measure CHIP (clonal hematopoiesis of indeterminate origin, blood stem cell mutation) but it is the one factor that helps predict who will benefit from low dose aspirin
jamanetwork.com/journals/jam…
Michael Rauh retweeted
Congratulations to Alex McDonald who successfully defended her MSc thesis examination!! @QMyPath @QueensuDOM @queensgradstudy @QueensUHealth
