Michael Rauh retweeted
Our latest work, uncovering the origins of microglia in human aging! Link to article below
👇
Gaining therapeutic access to the human brain is one of the biggest unsolved problems in biomedical science.
Today @nature, we uncover a massive influx of immune cells into the human brain during aging, revealing that the brain is more accessible than previously thought. 1/
nature.com/articles/s41586-0…
Michael Rauh retweeted
Gaining therapeutic access to the human brain is one of the biggest unsolved problems in biomedical science.
Today @nature, we uncover a massive influx of immune cells into the human brain during aging, revealing that the brain is more accessible than previously thought. 1/
nature.com/articles/s41586-0…
Michael Rauh retweeted
It's been a while now, but @DrFlashHeart and I are excited to share that our work exploring somatic gene x environment interactions between CHIP and air pollution in lung cancer is now published in @JNCI_Now
doi.org/10.1093/jnci/djag159
Air pollution is a recently recognized driver of lung cancer among never-smokers.
In a new preprint, we show that clonal hematopoiesis of indeterminate potential (CHIP) and PM2.5 form a novel gene × environment interaction promoting NSCLC tumorigenesis.
medrxiv.org/content/10.1101/…
Michael Rauh retweeted
✨ Thrilled to share our new publication in Nature.
We define an “inflammatory memory” HSC state (HSC‑iM), linking lifelong inflammatory exposure to aging and disease.
📄 Article: nature.com/articles/s41586-0…
Grateful to an incredible team and global collaborators 💚💙
Michael Rauh retweeted
Very nice CH review series in Hematologica.
haematologica.org/issue/view…
Michael Rauh retweeted
New preprint out! We asked: can we tell which CHIP mutations actually matter for disease risk? Analyzing >1 million individuals across @ukbiobank, @AllofUsResearch, and @VUMChealth BioVU — here's what we found. 🧵 (1/9)
Michael Rauh retweeted
📢 Our review on clonal hematopoiesis + evolutionary dynamics using mathematics is now available online @NatureGenet Check it out! #CHIPsm
Modeling the evolutionary dynamics of clonal hematopoiesis -- @S_Marzban et al, Nature Genetics
rdcu.be/e4cP1
Michael Rauh retweeted
Happy International Day of Women & Girls in Science! 🌟 Celebrating the brilliant minds breaking barriers, sparking innovation, & inspiring future generations to dream bigger. Here’s to curiosity, discovery, and the power of science! 💡🔬 #WomenInScience #GirlsInSTEM #IDWGS2026
Michael Rauh retweeted
CHIP ahoy: charting a decade of discovery in clonal hematopoiesis | Haematologica haematologica.org/article/vi…
Michael Rauh retweeted
@rheumrob,@AlexBickMDPhD, & I are excited to share that our work is now out in @jclinicalinvest! CHIP epi studies underestimate the association between CHIP & disease using WGS vs deep sequencing. Many thanks to the co-authors, participants, & reviewers! doi.org/10.1172/JCI198861
Using a unique cohort of 10k doubly sequenced people in @VUMCDiscoveries's BioVU, @AlexBickMDPhD, @yash_pershad, and I investigated how well #WGS data really works for detecting #CHIP. medrxiv.org/content/10.1101/…. Thread below! 1/n
Michael Rauh retweeted
CHIP was associated with increased heart failure and ischemic cardiovascular disease risk after #cancer therapy in patients with solid tumors, especially among those with higher #chemotherapy exposure. ja.ma/3Nj5vuW
Michael Rauh retweeted
Clonal hematopoiesis driven by Dnmt3a mutations promotes metabolic disease development in mice
In this Research Letter, Bowen Yan @BowenyanYan, Olga A. Guryanova @gur_ola @UFHealthCancer @UF_Pharmacolo& team @UFMedicine report #ClonalHematopoiesis, an #aging related condition caused by mutations in the #blood system, promotes #obesity, and drives the risk of #diabetes and #MASLD in the context of a high-fat #diet: doi.org/10.1172/JCI197100
Michael Rauh retweeted
📢 Online today: Ancestry-dependent patterns of somatic mosaicism and clonal hematopoiesis mutations in over 125,000 individuals reveal distinct cancer associations rdcu.be/eSROU. A huge feat with pretty figures, driven by #ChristelleColinLeitzinger. 👏
🚨🚨 Our new manuscript is now available online!
Co-led with the awesome @mingxiangteng
Peripheral blood somatic mosaicism and clonal hematopoiesis across ancestry backgrounds medrxiv.org/content/10.1101/…
Congrats @DrFlashHeart (Caitlyn Vlasschaert) on your work providing 🩸clonal hematopoiesis 🧬genetic phenotypes for @uk_biobank in conjunction with @AlexBickMDPhD @jaiswalmdphd @pnatarajanmd & others. An incredible resource for the world! #CH #CHIP @QueensUHealth @QueensuDOM biobank.ndph.ox.ac.uk/showca…
Michael Rauh retweeted
Happy to share that our work on TET2 CH in ICI therapy is now out in @CR_AACR!
We found that TET2 mutations promote myeloid co-stimulatory programs and suppress T cell exhaustion, contributing to improved immunotherapy response!
🔗Read more here: doi.org/10.1158/0008-5472.CA…
Congrats Alex McDonald on your MSc graduation @tmedQueens ! ! 🎉🍁
You made fundamental discoveries about clonal hematopoiesis and risk of Alzheimer disease, and contributions to this paper @CellStemCell . Amazing!!🤩
doi.org/10.1016/j.stem.2025.…
Michael Rauh retweeted
CHIP variants are often discovered incidentally in liquid biopsy testing, but is plasma cell-free DNA reliable when CHIP variants are the desired finding? 🩸@BloodAdvances @AlexBickMDPhD 🧵1/12
Michael Rauh retweeted
Congratulations to @PMResearch_UHN's Dr. Robert Vanner, who leads a team awarded $1M through @BrainCanada and @SRC_CRS's 2025 Translational Research Grant in Brain Cancer! 🎉
🔗Learn more about the project focused on advancing #glioblastoma research: braincanada.ca/funded_grants…
🚨 Big news in #braincancer research! Brain Canada & @SRC_CRS are funding 2 top teams: Dr. Robert Vanner & Dr. Sheila Singh with $1M each over 3 years.
@CDCR_Mac @UnityHealthTO
Read more ➡️ braincanada.ca/announcements…
