Pyr Brain Game retweeted
Happy to share the CA3 dataset is published. First large-scale dense connectomics from hippocampus. First connectomic dataset imaged in @PrincetonNeuro. A harbinger of many larger datasets to come (for both). doi.org/10.1038/s41593-026-0… (1/3)
Pyr Brain Game retweeted
That escalated quickly. Claude Blender MCP>>
Data from our project pyr.ai ~ follow @PyrGame for future dataset drops and check out this preprint: "Connectomic reconstruction from hippocampal CA3 reveals spatially graded mossy fiber inputs and selective feedforward inhibition to pyramidal" cellshttps://www.biorxiv.org/content/10.1101/2025.07.09.663979v1
Pyr Brain Game retweeted
We are delighted to announce that thanks to generous support from Research to Prevent Blindness @RPB_org, Eyewire II is now officially underway!
RPB has granted @NUFeinbergMed a $950,000 RPB Transformational Team Science Award to support the @eye_wire II project to create the first complete connectome in the mammalian central nervous system with @Princeton and University of Tübingen. bit.ly/RPBTTSA
ALT This render shows 370 retinal cells that compute visual information, such as motion. Many of these cells send information from the back of the eye directly into the brain. These cells are part of Eyewire 2, which is building the world’s largest synapse resolution retinal connectomics dataset to help decipher the cells and circuits that make vision possible. PHOTO CREDIT: Amy Sterling, EyeWire II, Princeton University
Pyr Brain Game retweeted
The Institute for Advanced Study (@the_IAS), the fabled home of Einstein and Gödel, announces a 2026-27 program on Modeling Fly Vision, intended to refound theor/comp neuro on the bedrock of 21st century brain maps. Apply for membership! ias.edu/sns/csb#special-year
Pyr Brain Game retweeted
My latest #neuro #visualization:
An intuition pump on connectivity in the #brain
~75K #neurons in the #MICrONS mm³.
I/O segregated by layers, function is columnar; the cortical column is the unit of cortical computation.
A typical #pyramidal cell has over >10K input #synapses.
Pyr Brain Game retweeted
This might make you think twice next time you reach for the fly swatter. The whole brain wiring diagram of the fly! All 140,000 neurons and their 50M synapses are available to explore in Codex, the Connectome Data Explorer: codex.flywire.ai/ #sfn23
Pyr Brain Game retweeted
It's #BrainAwarenessWeek! If you're curious about mapping the brain and connectomics, check out this science page we created with @PyrGame. It's loaded with illustrations and 3D renders science.eyewire.org/ Thanks for organizing, @dana_fdn!
Pyr Brain Game retweeted
The BRAIN Initiative Meeting website is now live! Learn more about the meeting and check out the agenda: brainmeeting.swoogo.com/2023… #studyBRAIN
Pyr Brain Game retweeted
When we think about communication between neurons, we often think about synapses. But as you can see in this week's #EM_Monday images, the cell body of neurons can come into contact with each other, and this contact area is huge compared to synapses. So do the neurons use...(1/n)
Pyr Brain Game retweeted
What is it like to be a dendrite?
My last visualization of #MICrONS layer2/3, to show the density of synapses and neuronal processes from a dendrites point of view. Previously shown the density from the outside looking in, this animation shows the complexity from the inside. 2/4
Pyr Brain Game retweeted
Our analysis of the connections between excitatory L2/3 pyramidal cells in mouse V1 just came out in eLife! Amazing team work between @PrincetonNeuro @bcmhouston @AllenInstitute
Previous tweet thread:
xitter.cf/tmacrina/status/121283…
elifesciences.org/articles/7…
Our scientists & collaborators used the largest map of connectivity to date between cortical neurons of a defined type (L2/3 pyramidal cells in mouse primary visual cortex), to identify constraints on the learning algorithms employed by the cortex.
📄 elifesciences.org/articles/7…
Pyr Brain Game retweeted
Named in honor of legend @usainbolt, Bolt Neurons (BPNs) drive fly sprints. Recently discovered by @SalilBidaye and published in @NeuroCellPress pubmed.ncbi.nlm.nih.gov/3282…, FlyWire analysis revealed 4 subtypes that may play a role in walking initiation & velocity control.
Pyr Brain Game retweeted
Today, @NIH announced two transformative BRAIN Initiative projects: The BRAIN InitiativeCell Atlas Network (11 grants totaling $100M annually over 5 yrs) and the Armamentarium for Precision Brain Cell Access (7 grants totaling $36M over 3 yrs) tinyurl.com/2fzwjc3b #studyBRAIN
Pyr Brain Game retweeted
Congratulations to the citizen scientists in FlyWire who recently proofread their 5,000th neuron and have together made over 75,000 edits! The left optic lobe is now 20% proofread. flywire.ai/
Pyr Brain Game retweeted
In a new blog, @NIH BRAIN Initiative Director John Ngai recaps the 2022 BRAIN PI meeting, including talks by @Bautista_DianaM, @eabuffalo, and @KafuiDzirasa, all of which can be viewed in our archive tinyurl.com/2rxogqop #studyBRAIN
Pyr Brain Game retweeted
Spectacular drosophila auditory circuitry. A new paper that utilizes FlyWire for connectomics is out today in @CurrentBiology @CellPressNews: cell.com/current-biology/ful…
Pyr Brain Game retweeted
Now we’re calling on the fly community to help us crowdsource the naming of cells, relying on your expertise. Sign up here to add names for any cells you recognize!
docs.google.com/document/d/1…