Check out pyramidal cells and mossy fibers from the CA3 volume on the cover of @NatureNeuro.
Read the paper (open access): Hippocampal CA3 connectomics reveals a gradient of mossy fiber inputs and selective feedforward inhibition onto pyramidal cells nature.com/articles/s41593-0…
These cells are thought to participate in pattern separation, pattern completion and memory encoding.
182 of 1,815 pyramidal cells from the CA3 volume, now out in @NatureNeuro nature.com/articles/s41593-0…
Pyr Brain Game retweeted
Happy to share the CA3 dataset is published. First large-scale dense connectomics from hippocampus. First connectomic dataset imaged in @PrincetonNeuro. A harbinger of many larger datasets to come (for both). doi.org/10.1038/s41593-026-0… (1/3)
Pyr Brain Game retweeted
That escalated quickly. Claude Blender MCP>>
Data from our project pyr.ai ~ follow @PyrGame for future dataset drops and check out this preprint: "Connectomic reconstruction from hippocampal CA3 reveals spatially graded mossy fiber inputs and selective feedforward inhibition to pyramidal" cellshttps://www.biorxiv.org/content/10.1101/2025.07.09.663979v1
Pyr Brain Game retweeted
We are delighted to announce that thanks to generous support from Research to Prevent Blindness @RPB_org, Eyewire II is now officially underway!
RPB has granted @NUFeinbergMed a $950,000 RPB Transformational Team Science Award to support the @eye_wire II project to create the first complete connectome in the mammalian central nervous system with @Princeton and University of Tübingen. bit.ly/RPBTTSA
ALT This render shows 370 retinal cells that compute visual information, such as motion. Many of these cells send information from the back of the eye directly into the brain. These cells are part of Eyewire 2, which is building the world’s largest synapse resolution retinal connectomics dataset to help decipher the cells and circuits that make vision possible. PHOTO CREDIT: Amy Sterling, EyeWire II, Princeton University
Pyr Brain Game retweeted
The Institute for Advanced Study (@the_IAS), the fabled home of Einstein and Gödel, announces a 2026-27 program on Modeling Fly Vision, intended to refound theor/comp neuro on the bedrock of 21st century brain maps. Apply for membership! ias.edu/sns/csb#special-year
New preprint alert: hippocampus CA3!
∼1×1×0.1mm3 volume with 1,815 pyramidal neurons, 229 inhibitory cells, and 55,000 mossy fibers (like the ones shown below). Access the data at pyr.ai and explore the preprint below
Excited to share a connectomics dataset of hippocampus CA3.
Explore the dataset: pyr.ai
Paper introducing the dataset and some of our discoveries: biorxiv.org/content/10.1101/…
A quick guide to 3D neuron navigation in neuroglancer: youtu.be/4Pi0QpjkDcI (try saying that 3 times fast)
Explore interactive neurons from the microns dataset: microns-explorer.org/gallery…
mossy fiber with several long filopodia
request early access to Pyr CA3 dataset to unlock interactive 3D: play.pyr.ai/#!middleauth+htt…
pyr.ai/ca3_access
A spiraling dance of neural threads,
twisting, branching, in the head.
A tangle born of thought and time,
synapses spark and neurons climb.
In crimson rivers, pathways stream,
etching maps of hidden dreams.
Image from CA3 by Nseraf
>1,000 axons presynaptic to CA3 spiny pyramidal neurons have been proofread by citizen scientists. pyr.ai/
A few presynaptic axons connecting to a CA3 pyramidal neuron. Request early dataset access here: pyr.ai
🔥⚡ Action Potential: When neurons gossip ⚡🔥
"Hey, did you hear? Na+ rushed in, K+ stormed out, and BAM 💥 signal sent!"
Sparking thoughts, moves, and feels. science.eyewire.org/neurons