Working on cancer research and cell signalling at the University of Liverpool.
University of Liverpool.
Joined May 2011
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Ian Prior retweeted
🧠🔬Are passionate about EM, neurons, ageing, neurodegeneration, Drosophila?
Funded 4-year BBSRC NWD PhD to advance neuroscience through vCLEM techniques.
🙏repost this project with
@PriorLab
@Natsansor
@AlisonBeckett11
findaphd.com/phds/project/bb…
Ian Prior retweeted
Returning to the lab after a great week at @BiochemSoc Small G Proteins in Cellular Signalling and Disease 2025.
Blown away by the high calibre of research on display, and grateful to have been able to showcase our work after years in development.
#BiochemEvent #SGP25
ALT https://www.linkedin.com/posts/hlahiff_biochemevent-biochemawards-sgp25-activity-7345767226265812992-kbmZ?utm_source=share&utm_medium=member_desktop&rcm=ACoAACvmAZkBkaRFPkrRLEJXZsO5NUPHHoZ4Rjo
Ian Prior retweeted
Thoroughly enjoyable work and some surprise findings! The first journey into the chromosome periphery in mammalian oocytes with @TheMitosisBooth and @wthrll. Great team science with several labs across Institutions @kinetochore and @PriorLab biorxiv.org/content/10.1101/…
1) There has been super work in recent years, from multiple labs - but almost all have centred on a mitotic CP. But what about a CP in meiosis, eg in oocytes! Check out this work - from a great collaborative team! biorxiv.org/content/10.1101/…
@SuzanneMadgwick @kinetochore @UoN_BDI
Ian Prior retweeted
🆕#TLevelToolkit for UK universities who want to host #TLevel placements, but don't know where to start
📽️ Hear what #TLevel students say about their experience @LivUni @LivUniTechNet @ElearnerMatt
➡️Download your free toolkit buff.ly/4hqcCw6
Ian Prior retweeted
I have a BBSRC CTP PhD on protein kinases & cancer therapies available to start in Oct 2025. It is a collaboration between my lab @BabrahamInst and @CR_Horizons @BabrahamUK We're a friendly bunch. We like cake. What's not to like? Please RT
babraham.ac.uk/work-and-stud…
Ian Prior retweeted
#Chromosomes in early prometaphase are longer, have a more granular surface, and lack a primary constriction. From Cisneros-Soberanis, Simpson, Earnshaw et al. @WTcell: hubs.la/Q02Mx5G40
#StructuralBiology #Mitosis #CellDivision
Ian Prior retweeted
🆕#TLevelToolkit for UK universities who want to host #TLevel placements, but don't know where to start
📽️ Hear from @LivUni @LivUniTechNet @PdGilbert @PriorLab @ElearnerMatt about the benefits of hosting #TLevel placements
➡️Download your free toolkit buff.ly/3MBPpct
Ian Prior retweeted
An atlas of genetic effects on cellular composition of the tumor microenvironment @NatImmunol
nature.com/articles/s41590-0…
Ian Prior retweeted
Online Now: Distinct clinical outcomes and biological features of specific KRAS mutants in human pancreatic cancer dlvr.it/TCXth0
Ian Prior retweeted
Thrilled to share progress on Ras isoform binders! Using AI-driven protein design, I’ve targeted the challenging, highly charged and disordered C-terminus of Ras. These de novo binders exceed antibody specificity and effectively disrupt Ras signaling. biorxiv.org/content/10.1101/…
ALT Design pipeline for making Ras isoform binders.
Ian Prior retweeted
RAS-ON inhibition overcomes clinical resistance to KRAS G12C-OFF covalent blockade | Nature Communications nature.com/articles/s41467-0…
Ian Prior retweeted
Exciting talk from @AndrewMWaters about the distinct resistance mechanisms of different #RAS inhibitors in #pancreaticcancer @FASEBorg Function & Regulation of Small #GTPases meeting. Can’t wait what his lab @uofcincycancer will achieve in the coming years! #RGTPSRC
Ian Prior retweeted
Proud to have our first @UCincyMedicine @UCincySurg co-authored publication out in @nature collaborating with Revolution Medicines. We are swinging for the fences to #killkras
@KRASKickers @PanCAN @SyedAAhmad5 @grace_goodhart
nature.com/articles/s41586-0… – at San Diego, CA
Ian Prior retweeted
Today is our annual Shared Research Facilities (LIV-SRF) showcase event. Through teaser talks, stalls and case studies, facilities will highlight the cutting-edge technology and expertise on offer to internal and external users. #LIVSRF24
Ian Prior retweeted
Prof Tim Jones kicking off our inaugural LIV-SRF Showcase! #LIVSRF24 @livuniLivSRF – at Liverpool, England
Ian Prior retweeted
Delighted our work on the importance of choosing the right proliferation assay is now published. This could have affected the assessment of many drugs, especially anti-cancer drugs, although our work focussed on CDK4/6 inhibitors. (Tweets to explain below)
nature.com/articles/s41523-0…
Ian Prior retweeted
Register now - @LivUni Liverpool Shared Research Facilities Showcase. This one-day event on the 25 March is free and open to everyone. A fantastic opportunity to hear about the wealth of expertise and cutting-edge technology on offer to external users bit.ly/3OFUYId
Ian Prior retweeted
PerturbView enables in vivo CRISPR screens with single cell spatial resolution (biorxiv.org/content/10.1101/…). CRISPR sgRNA are uniquely identified over 6 rounds of in situ sequencing. Attached is an animation of in situ sequencing of sgRNAs in a tumor xenograft (1/4)
Ian Prior retweeted
Why drug holidays? Matthias simple mathematical model shows how intermittent treatment outperforms continuous treatment, both if two populations of tumour cells exist or if resistance is induced by the treatment. @compcancer doi.org/10.1016/j.jtbi.2023.…
Ian Prior retweeted
Thrilled to see our latest work on CDK4/6 inhibitors published in two back-to-back articles. Check out the manuscripts here and read a thread that describes them below [1/16]
cell.com/molecular-cell/full…
cell.com/molecular-cell/full…
