Professor @GeiselMed @Dartmouth @DMS_MicroImmuno; Laboratory of Antifungal Immunity // Director @MCBDartmouth // JV Soccer Coach @hcaneswirl
Lebanon, NH
Joined March 2020
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Excited to share our most recent pre-print on the role of mycoviruses in triggering the antifungal MAVS-dependent interferon response and their role in regulating chronic allergic bronchopulmonary aspergillosis (ABPA) disease severity.
biorxiv.org/content/10.64898…
ObarLab retweeted
Recently published work in our lab identified keratinocyte VISTA as an epidermal checkpoint that restrains skin type I IFN response and UV light-induced injury. #lupus #photosensitivity @ZacharyTPeters @JCI_insight @GeiselMed @MCBDartmouth insight.jci.org/articles/vie…
ObarLab retweeted
Congratulations to boys soccer for securing the SVL-B title last night! This is league title #17 for the program and 5th in the last 8 seasons. (1991, 1993, 1995, 1996, 1997, 1998, 2003, 2004, 2009, 2011, 2012, 2013, 2019, 2022, 2023, 2024, 2026). Well done Canes!!
ObarLab retweeted
We are hiring - at the new Center for Pathogen Immunology in the Department of Microbiology @nyugrossman @nyulangone linkedin.com/jobs/view/44746…
ObarLab retweeted
Thrilled to share this labor of love, #freshoffthepress in @Nature about how Type 2 immune history trains lung macrophages for viral disease tolerance.👇
nature.com/articles/s41586-0…
This was impossible without my mentor @Kamal_M_Khanna & our coauthors. 🧵 on 🦋payalyokota.bsky.social
Happy to share our new paper in @Nature “Type 2 immune history trains lung macrophages for viral disease tolerance” nature.com/articles/s41586-0… the work was fearlessly led by @PayalYokota Thanks to all our collaborators! @nyulangone @nyugrossman
ObarLab retweeted
Happy to share our new paper in @Nature “Type 2 immune history trains lung macrophages for viral disease tolerance” nature.com/articles/s41586-0… the work was fearlessly led by @PayalYokota Thanks to all our collaborators! @nyulangone @nyugrossman
ObarLab retweeted
🍄Full program for 2027 GRC Immunology of Fungal Infections is now online!
👀Think it looks good? Apply now - only a handful of spaces are left to grab!
🚨Fellowships available for those who qualify.
All details and the program are here:
grc.org/immunology-of-fungal…
ObarLab retweeted
🚨Spaces are filling up fast for the 2027 GRC
Immunology Fungal Infections meeting - submit your application now to avoid missing out! Full program available next week but you can see the invited speakers here:
grc.org/immunology-of-fungal…
ObarLab retweeted
Our new studies show that neutrophils increase in the urine of #lupus patients with active skin disease, in LN kidneys, and after skin exposure to UV, promoting renal tissue remodeling. @J_Immunol @andreafaa
@GeiselMed @DartmouthHealth @MCBDartmouth academic.oup.com/jimmunol/ar…
ObarLab retweeted
We previously showed that APS-1/APECED features excess IFNg responses that can be targeted therapeutically (Oikonomou NEJM 2024). We now extend this to show that early JAK inhibition can intercept the development of irreversible autoimmune endocrinopathies
nature.com/articles/s41467-0…
ObarLab retweeted
📢 The abstract deadline for the 2027 Gordon Research Conference on Immunology of Fungal Infections is approaching. Submit by September 1, 2026 for consideration for a short talk.#FungalImmunology #GRC See details: grc.org/immunology-of-fungal…
ObarLab retweeted
MCB Students and Alumni: The 4th Annual Gary Heussler Alumni Lecture will be presented Sept. 18th by Megan O'Connor! The lecture will be followed by a networking event to connect students and alumni.
Alumni: If you didn't get an email last Friday, please comment/DM!
Congratulations to my PhD student, @abigailpmcgee, who was awarded her F31 today looking the role of MAVS in regulating mitochondrial health and cell survival.
ObarLab retweeted
Thrilled to share my second postdoc paper, out today in @SciImmunology. We continued dissecting the host response to fungal pathogens in the lung and uncovered another spatial circuit that shapes macrophage function and pathogen persistence.
#Macrophage-derived cholesterol metabolites called oxysterols recruit immunosuppressive T helper 2 (#TH2) cells to fungal lesions in the lungs of mice. @EricVDang1 @yufanzheng7
Learn more in Science #Immunology: scim.ag/4wO0cFq
ObarLab retweeted
A new PAMP, a new innate immunity principle and a new preclinical application. I am so pleased to share our study on STING activation mechanisms in health and disease. Led by the fantastic Stephanie Ragland, follow the summary below for all we learned.
cell.com/immunity/fulltext/S…
Our work with @andolive85’s lab is now live @J_Immunol in which we demonstrate alveolar macrophage are potent inducers of the type I interferon response
A #CuttingEdge article suggests TGFβ modulates the metabolic networks and immune signaling cascades of alveolar macrophages to control inflammatory pathways and that the role of type I IFNs is a key initial response to invading pathogens in the lungs. ow.ly/nmIW50ZhTkV.
ALT Mitochondrial ROS contributes to TGFβ-dependent IFN responses. (A) WT TGFβ (−) FLAMs and WT or Mavs KO TGFβ (+) FLAMs were stained for the peroxisomal markers PMP70 and catalase in addition to cellular DNA with DAPI. Shown are representative images from at least 3 independent experiments. The far-left column images were taken with a 100× oil objective; inset images were cropped to a single cell and have a scale bar that is 10 μm in size. (B) MFI of each peroxisomal marker in (A) was quantified. Each individual data point represents a single cell from a representative experiment. (C) WT TGFβ (−) FLAMs and WT or Mavs KO TGFβ (+) FLAMs were stained for the mitochondrial markers Tomm20 and ATP synthase in addition to cellular DNA with DAPI. Shown are representative images from at least 3 independent experiments. The far-left column images were taken with a 100× oil objective; inset images were cropped to a single cell and have a scale bar that is 10 μm in size.
ObarLab retweeted
Championship Day! Boys lax heads to Burlington to face #1 Harwood in a 6:00 game at Virtue Field (UVM). Tickets available on GoFan or at the gate. Fan bus departs at 4:15 from HHS. Might want to bring some rain gear... #GoCanes!!!
ObarLab retweeted
👉 HIF activity prevents proper macrophage maturation
Deleting VHL → stabilizes HIFs → immature AM phenotype
Only removing BOTH HIF-1α + HIF-2α fully restores identity
👉 HIF signaling is the dominant driver downstream of VHL
ObarLab retweeted
#InterferonPower! #InflammasomePower! 💥With @kjena21 &co we show @NatImmunol that our fungal adjuvant #Mannadjuvant, via IL1 & IFNs, prolongs & potentiates protection of #mRNA #vaccines, broadening it to new variants & overcoming antigenic imprinting! 👉 nature.com/articles/s41590-0…
