š§ Modelling neurodegenerative diseases š¼ Job openings National Neuroscience Institute
Singapore
Joined August 2022
- Tweets26
- Following119
- Followers38
- Likes5
Pinned Tweet
We are looking for a motivated #bioinformatician (immediate position) to analyze #transcriptomic data on #neurodegenerative diseases to join our lab. All PhD, MSc and BSc with relevant experience are welcome to apply!
jobstreet.com.sg/en/job/seniā¦
Check out our latest study on the effects of itanapraced on #Parkinsons disease! Thanks @mnt for the feature šš¼
Alzheimerās drug candidate may have potential for treating Parkinsonās disease zpr.io/yMKhmUe6ZXhW #ScienceTwitter
Neural Stem Cell Research Lab retweeted
Upcoming ā¦ @devbio_sg virtual ā©seminar by Associate Professor Quenten Schwarz on interneuron development, happening on 27 October! ā¦ @phil1pingham @MonteiroLab @onsunlau_nus @NSCRLab @HongyanWang9 @Yusuke_Toyama @ReversadeLab @unisaresearch
Neural Stem Cell Research Lab retweeted
Upcoming exciting ā¦@devbio_sgā© seminar by Anna Akhmanova on #microtubules! ā¦@phil1pinghamā© ā¦@MonteiroLabā© ā¦@onsunlau_nusā© ā¦@NSCRLabā© @HongyanWang9ā© ā¦@Yusuke_Toyamaā© ā¦@ReversadeLabā©
Neural Stem Cell Research Lab retweeted
SCSS Symposium 2022: Registration is open - mailchi.mp/d04991d7e09c/scssā¦
Thanks for the feature! @Ingentium_PD The APP intracellular domain promotes LRRK2 expression to enable feed-forward neurodegenerative mechanisms in Parkinson's disease. magazine.ingentium.com/2022/ā¦
Neural Stem Cell Research Lab retweeted
An experimental therapy for Alzheimerās disease can break a molecular loop and protect neurons in mouse models of Parkinsonās disease, hinting similar approaches could prove beneficial for this incurable neurodegenerative condition. @NSCRLab #Neuroscience fcld.ly/2ro163e
Neural Stem Cell Research Lab retweeted
Annovis Bio @AnnovisBio has announced that the 1st patient in the Phase 3 clinical trial evaluating buntanetap (aka ANVS401, Posiphen) in early stage #Parkinsons has been dosed; The trial will enroll a total of 450 participants, treatment for 6 months
irpages2.eqs.com/websites/anā¦
Just today, our paper on a feed-forward loop between the APP intracellular domain (AICD) fragment and the kinase LRRK2 which promotes #Parkinsonsdisease pathology was published on @scisignal #ScienceSignalingResearch
science.org/doi/10.1126/scisā¦
We propose that AICD cooperates with transcription factor of FOXO3a to promote LRRK2 transcriptional activation and expression. Experimental drug, itanapraced, inhibits LRRK2-mediated neurotoxicity. @ScienceMagazine @scisignal #Parkinsonsdisease
Neural Stem Cell Research Lab retweeted
An experimental treatment for Alzheimerās disease can break a molecular loop and protect neurons in mouse models of #ParkinsonsDisease, suggesting similar approaches could prove beneficial for this incurable neurodegenerative condition. fcld.ly/j7bul55 @SciSignal
Neural Stem Cell Research Lab retweeted
A positive feedback loop between AICD and #LRRK2 drives #neurodegeneration and mitochondrial dysfunction in #ParkinsonsDisease but can be targeted with the experimental drug itanapraced, show experiments in mice from the Tan and Zeng labs. @mysgh @NSCRLab fcld.ly/ccrcssg
Neural Stem Cell Research Lab retweeted
New paper from the @NSCRLab! They found that in cultured neurons & brain tissue from mouse models of #ParkinsonsDisease, LRRK2-mediated phosphorylation of APP increased the abundance and activity of the APP intracellular domain. š§
@scisignal
https://xitter.cf/t.co/uZwqFKFCNG
Neural Stem Cell Research Lab retweeted
A self-sustaining molecular loop that drives Parkinsonās disease can be targeted in mice, new research answers a longstanding question about Wnt signaling, and more in this weekās new issue of Science Signaling. fcld.ly/q53lnia
We found that blood miR-150-5p was upregulated in #AlzheimersDisease #Dementia which could be a promising cost-effective and non-invasive biomarker for AD. Read our article published in @journal_ad!
pubmed.ncbi.nlm.nih.gov/3581ā¦
Earlier this year, we published on @BioMedCentral reporting the increased expression of pathological markers in Parkinsonās disease dementia post-mortem brains compared to dementia with Lewy bodies. Check it out! #Parkinsonsdisease #lewybody
bmcneurosci.biomedcentral.coā¦
