Beta-catenin promotes cancer cell growth but B-cell leukemia cells, unexpectedly, depend on its efficient degradation. Our paper out today in @naturecancer, shows how this dependency could be leveraged for the benefit of patients with B-ALL.👇 nature.com/articles/s43018-0…

Wonderful to be hosting Michael Reth @theNASciences , who discovered the ITAM and pioneer in immune receptor signaling. Thank you for an inspirational seminar @YaleIBIO and private brainstorming session over breakfast.

Excited to be hosting Maya Graham @MSKCancerCenter today at @YaleCancer. Many thanks, Maya, for a wonderful seminar, sharing new insights in the biology of oncohistones in the etiology of pediatric gliomas.

Thank you, Stephanie Xie @stephxie @PMResearch_UHN for visiting us at Yale, a wonderful seminar and sharing exciting new insights into inflammatory memory of human HSCs!

Many thanks to Vignesh Shanmugam @Vignesh_Shan for visiting us today at Yale @YaleCancer and for sharing exciting new results on how lymphomas shape their microenvironment -brainstorming with Yanzhi Feng, Kohei Kume and Zhangliang Cheng.

A first of it's kind, the 'Oncogene hyperactivation' conference highlighted an emerging paradigm in cancer research. Many thanks to Harold Varmus, René Bernards @BernardsLabora1, Kim Stegmaier @KStegmaier_DFCI and Bill Sellers for bringing together this eclectic group!

Proud mentor alert: Etienne Leveille gave a spectacular overview of our work at the first international meeting on 'Oncogene hyperactivation' as a new paradigm to treat cancer. Harnessing oncogene hyperactivation to induce negative selection in B-cell malignancies.

Many thanks to Arndt Borkhardt @Borkhardt_Lab, Andi Roy @andiroy and Merja Heinäniemi @heinaniemi for organizing this stimulating workshop on clonal evolution of pediatric leukemias. Exciting science and always nice to come home to beautiful Düsseldorf.

Definitely not the healthiest of all choices, but auspicious colors, red and gold. Prepping Lunar New Year breakfast snacks for lab meeting.

Happy New Year of the Dragon!

Congratulations, @jaehyukchoimd,@julie_garcia, @KoleRoybal, @jay__daniels. Fascinating to see how CARD11-PI3R3 and other "oncogenic drivers" can be harnessed to improve T-cell therapies. Clonal evolution in cancer and the immune system working in similar ways.