B-cell dynamics, oncogenic signaling in B-cell malignancies @YaleUniversity. Since January 2026 @muschenlab.bsky.social
New Haven, CT
Joined January 2021
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Müschen Lab retweeted
A signaling loop centering on the protein CD25 sustains the growth of acute leukemias such as #AML and #B-ALL by fine-tuning the activity of oncogenic tyrosine kinases, according to a new study. @MuschenLab @Yale scim.ag/4rMXddQ
Yale Study Identifies a New Class of Drug Targets for Aggressive Leukemia m.yale.edu/dfyw
On this week's cover of Science Signaling. Congratulations to Ruifeng Sun and Jaewoong Lee, who led this effort! Dynamic feedback control of oncogenic tyrosine kinase signaling in acute leukemia | Science Signaling science.org/eprint/ZZKJPHHXR…
EACR - Overactivation of Oncogenic Signalling as a Potential Cancer Treatment Strategy - ecancer ecancer.org/en/conference/15…
Beta-catenin promotes cancer cell growth but B-cell leukemia cells, unexpectedly, depend on its efficient degradation. Our paper out today in @naturecancer, shows how this dependency could be leveraged for the benefit of patients with B-ALL.👇 nature.com/articles/s43018-0…
👇In a few weeks, the Samir Zaidi Lab will open at Yale. Exciting and important science and a generous and supportive mentor - phenomenal opportunity for future graduate students and postdocs with an interest in lineage plasticity and drug resistance in cancer.
Fifteen years ago, my wife, Salimah, and I met as graduate students at @Yale in New Haven. Now, in a full-circle moment, I’m thrilled to share that I’ll be joining the @YaleCancer and @ynhhealth to launch my independent lab in March 2025! @samirzaidi
I’ll be based in the Center of Molecular and Cellular Oncology and look forward to collaborating with incredible scientists like @BraunMDPhD, @ishizukalab, @S_J_Aitken, #CarolineMlynarczyk, #FrederickWilson and many others, under the leadership of @MuschenLab.
I’m deeply grateful for the invaluable mentorship at @MSKCancerCenter ––from #CharlesSawyers @SawyersLabMSKCC, #MichaelMorris, @DrRosenbergMSK —who have guided me along this path.
This transition wouldn’t have been possible without the unwavering support and vision of @DrEricWiner. His leadership made Yale feel not just like an exciting scientific home, but a truly warm and welcoming community—one that I can’t wait to be a part of.
Excited to continue seeing patients in my clinic at @YaleCancer, and of course, to introduce our two boys to some legendary New Haven pizza!
Welcome back to Yale, Samir. So glad to have you joining us!
Fifteen years ago, my wife, Salimah, and I met as graduate students at @Yale in New Haven. Now, in a full-circle moment, I’m thrilled to share that I’ll be joining the @YaleCancer and @ynhhealth to launch my independent lab in March 2025! @samirzaidi
I’ll be based in the Center of Molecular and Cellular Oncology and look forward to collaborating with incredible scientists like @BraunMDPhD, @ishizukalab, @S_J_Aitken, #CarolineMlynarczyk, #FrederickWilson and many others, under the leadership of @MuschenLab.
I’m deeply grateful for the invaluable mentorship at @MSKCancerCenter ––from #CharlesSawyers @SawyersLabMSKCC, #MichaelMorris, @DrRosenbergMSK —who have guided me along this path.
This transition wouldn’t have been possible without the unwavering support and vision of @DrEricWiner. His leadership made Yale feel not just like an exciting scientific home, but a truly warm and welcoming community—one that I can’t wait to be a part of.
Excited to continue seeing patients in my clinic at @YaleCancer, and of course, to introduce our two boys to some legendary New Haven pizza!
Müschen Lab retweeted
New research presented at #ASH24 from the @MuschenLab by @RuifengSun2 shows the previously unrecognized role of PKCδ and CD25 in to control BCR signaling in Mature B-Cell #Lymphoma. @YaleMed @OncoAlert @YaleHematology
ash.confex.com/ash/2024/webp…
Müschen Lab retweeted
.@RuifengSun2 presents research @MuschenLab showing CD25 as a regulator of the B pathway and suggesting it as a new therapeutic target for acute lymphoblastic leukemia #ALL at #ASH24. @YaleHematology @OncoAlert @YaleMed @YaleIBIO ash.confex.com/ash/2024/webp…
Müschen Lab retweeted
Zhangliang Cheng @MuschenLab presents on the 3 stages of B Cells and oscillations between MYC and BCL6 dependent states in B Cell #lymphoma. #ASH24 @YaleMed @SmilowCancer
Congratulations, both of you!
We all have our scientific role models. I’m so lucky that mine was my own mom. 1st-generation & running a lab while raising two boys, she overcame many barriers, to say the least. After 45 years of discoveries @MIT, I hope you enjoy retirement! news.mit.edu/2024/jane-jane-…
Müschen Lab retweeted
Leo Meriranta @Merijellona is defending his PhD thesis “molecular cross-section of high/risk #DLBCL” today. It is an honor to chair and enjoyable to listen high level scientific discussion lead by Dr Dan Hodson. Thank you Dan, well done Leo!
Welcome to Yale!
Super excited to share that we’ve moved to Yale University’s Department of Urology to continue our prostate cancer research. Already loving the Yale community and looking forward to some awesome collaborations ahead. @Yale_Urology @YaleMed @YaleCancer @Yale
Wonderful to be hosting Michael Reth @theNASciences , who discovered the ITAM and pioneer in immune receptor signaling. Thank you for an inspirational seminar @YaleIBIO and private brainstorming session over breakfast.
Müschen Lab retweeted
The ‘China Initiative’ failed US research and national security. Don’t bring it back. thehill.com/opinion/national…
Müschen Lab retweeted
Excited our final version of @tineisadora's work on targeted protein relocalization is out today @nature! Molecular control over protein localization could offer new opportunities for therapeutics and biological discovery. @Stanford_ChEMH @StanfordUChem nature.com/articles/s41586-0…
Congratulations, Uli, taking PU.1 research to a whole new level.
Very happy and proud to see this study on PU.1 transcription factor "redistribution" and its mechanistic implications out in @NatureGenet today. Huge congrats to lead author @SamuelJohnTayl1! (recruiters watch out: Sam is on the faculty job market now...!). A big thank you also to the entire collaborative team including the twitterless Gregory Poon and Kristy Stengel! @EinsteinCellBio @Einstein_SCI @EinsteinMed
Müschen Lab retweeted
Very happy and proud to see this study on PU.1 transcription factor "redistribution" and its mechanistic implications out in @NatureGenet today. Huge congrats to lead author @SamuelJohnTayl1! (recruiters watch out: Sam is on the faculty job market now...!). A big thank you also to the entire collaborative team including the twitterless Gregory Poon and Kristy Stengel! @EinsteinCellBio @Einstein_SCI @EinsteinMed
Super thrilled to share our article on pharmacological PU.1 repositioning published in Nature Genetics today! Massive thanks to everyone involved!
Article -> nature.com/articles/s41588-0…
A digestible PUree of the main findings (aka Research Brief) -> nature.com/articles/s41588-0…
Müschen Lab retweeted
Immunologists out there, join us in New York City and @nyugrossman !! All candidates will be considered but the ones with a track record in the development of cutting-edge experimental, engineering and computational approaches to analyze immune responses are particularly encouraged to apply. Apply at: apply.interfolio.com/155023 !! @NYUGSOM_Path #Immunology
