@MossbauerLab
 Pittsburgh, PA
chem.cmu.edu/groups/guo/
Joined November 2017
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  • Following256
  • Followers332
15Media
Regio- and Stereoselective Halogenation by an Iron(II)- and 2-Oxoglutarate-Dependent Halogenase in the Biosynthesis of Halogenated Nucleosides | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/jac…

Regio- and Stereoselective Halogenation by an Iron(II)- and 2‑Oxoglutarate-Dependent Halogenase in...

Abstract. Iron­(II)- and 2-oxoglutarate-dependent (Fe/2OG) enzymes have garnered strong research interest in past decades due to their ability to catalyze

pubs.acs.org
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Learn about graduate programs in @CMU_Chem in a virtual session on Nov. 25. Register here: apply-dc-mcs.mcs.cmu.edu/reg…

MCS | CHEM | F25 Virtual Info Session 3

 

apply-dc-mcs.mcs.cmu.edu
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Please consider to attend ICCC2024 this summer. You can find all the conference programs by following this link (iccc2024.colostate.edu). The abstract submission is due on April 26.
ICCC_2024@Iccc202415 Apr 2024
Registration is now live! conferencereg.colostate.edu/…
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The Penn State Bioinorganic Workshop will be offered from May 29 - June 4 - please see updates at sites.psu.edu/bioinorganic/2… with @jmarbol21 @BookerMan_PSU @CotruvoLab @StollPatrol @Prof_SJE @MossbauerLab @ShafaatLab @TamraBlue3 @jwilcoxen and many others
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This is cool!
Bernhard Research @ CMU
@bernlab27 Oct 2023
Happy Friday! No luminescence, but pretty colors
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A Porphyrin Iron(III) pi-Dication Species and its Relevance in Catalyst Design for the Umpolung of Nucleophiles (Johannes E. M. N. Klein and co-workers) @sileneengbers, @MossbauerLab, @lab_klein, @StratinghInst, @CMU_Chem #openaccess onlinelibrary.wiley.com/doi/…

A Porphyrin Iron(III) π‐Dication Species and its Relevance in Catalyst Design for the Umpolung of...

A key intermediate in bioinspired umpolung of nucleophiles is an iron(III) π-dication. We identify that the meso-substituent of the porphyrin controls its accessibility and report the detailed study...

onlinelibrary.wiley.com
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An S1 Iron(IV) Intermediate Revealed in a Non-Heme Iron Enzyme-Catalyzed Oxidative C-S Bond Formation (Yisong Guo and co-workers) @NCStateChem @Prof_SJE @BUChemisty @BUChemistry @MossbauerLab @CMU_Chem #AngewandteVIP #openaccess onlinelibrary.wiley.com/doi/…

An S=1 Iron(IV) Intermediate Revealed in a Non‐Heme Iron Enzyme‐Catalyzed Oxidative C−S Bond...

The first non-heme enzymatic S=1 Fe(IV) intermediate is discovered via transient kinetics and spectroscopic (Mössbauer, EPR, and XANES) characterizations. This novel species is a key intermediate to...

onlinelibrary.wiley.com
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Replying to @Chemjobber
We use internet-connected Raspberry Pis with cameras to monitor almost everything in the lab. Added benefit of remote access: You can  be disappointed about your reaction's performance 24/7
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Repurposing Iron- and 2-Oxoglutarate-Dependent Oxygenases to Catalyze Olefin Hydration (Chuo Chen and co-workers) @MossbauerLab @CMU_Chem @ncstatechem @UTSWGradSchool #openaccess onlinelibrary.wiley.com/doi/…

Repurposing Iron‐ and 2‐Oxoglutarate‐Dependent Oxygenases to Catalyze Olefin Hydration

It is shown that the 2-His-1-carboxylate coordination triad commonly deployed in Fe/2OG-dependent enzymes can be used as a general ligand system to support sequential hydrogen atom transfer and...

onlinelibrary.wiley.com
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A recent study led by Chang @NCStateChem and Chen @UTSWGradSchool and joined by us @MossbauerLab @CMU_Chem discovered that Fe/2OG dependent enzymes are capable of catalyzing 2OG independent Mukaiyama hydration! onlinelibrary.wiley.com/doi/…

Repurposing Iron‐ and 2‐Oxoglutarate‐Dependent Oxygenases to Catalyze Olefin Hydration

It is shown that the 2-His-1-carboxylate coordination triad commonly deployed in Fe/2OG-dependent enzymes can be used as a general ligand system to support sequential hydrogen atom transfer and...

onlinelibrary.wiley.com
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Is the Fe(IV) intermediate in non-heme iron enzymes always in an S = 2 spin state? Answer is No. A collaborative study by @lbgee1, Chang @NCStateChem, @Prof_SJE and Liu @BUChemistry, and us @CMU_Chem revealed the first S = 1 Fe(IV) in non-heme catalysis. onlinelibrary.wiley.com/doi/…

An S=1 Iron(IV) Intermediate Revealed in a Non‐Heme Iron Enzyme‐Catalyzed Oxidative C−S Bond...

The first non-heme enzymatic S=1 Fe(IV) intermediate is discovered via transient kinetics and spectroscopic (Mössbauer, EPR, and XANES) characterizations. This novel species is a key intermediate to...

onlinelibrary.wiley.com
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We are getting ready to celebrate 40 years of Larry Que's career at @UMNChemistry. Larry has mentored 150 researchers in this time. What an amazing career and I can't wait to hear more about #iron #enzymes and #catalysis in this party. #LQfest
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We thank @ChemicalScience for featuring our recent collaborative work on a novel triplet Iron(IV)-Bisimido complex with @Deng_SIOC and Ye @dicp_cas. The steric and electron-withdrawing nature of imido substituents enable unique chemical/physical and reactivity properties.
Chemical Science@ChemicalScience17 Mar 2023
NEW 🎨#ChemSciCovers 📢 Spin polarization assisted facile C–H activation by an S = 1 iron(iv)–bisimido complex: a comprehensive spectroscopic and theoretical investigation by L. Deng, S. Ye, Y. Guo et al. Read it here ➡️ ow.ly/6Qyv50NjLjs 🎨 by Samantha Zemanek
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Mechanistic Studies of Aziridine Formation Catalyzed by Mononuclear Non-Heme Iron #Enzymes by Lide Cha, Jared C. Paris, Brady Zanella, Martha Spletzer, Angela Yao, Yisong Guo @MossbauerLab at @CMU_Chem, and Wei-chen Chang at @NCStateChem in @J_A_C_S pubs.acs.org/doi/10.1021/jac…
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Seeing the cis-Dihydroxylating Intermediate: A Mononuclear Nonheme Iron-Peroxo Complex in cis-Dihydroxylation Reactions Modeling Rieske Dioxygenases #Dihydroxylation #Mononuclear #Nonheme #IronPeroxo #Rieske #Mechansim pubs.acs.org/doi/10.1021/jac…

Seeing the cis-Dihydroxylating Intermediate: A Mononuclear Nonheme Iron-Peroxo Complex in cis-Dih...

Abstract. The nature of reactive intermediates and the mechanism of the cis-dihydroxylation of arenes and olefins by Rieske dioxygenases and synthetic nonh

pubs.acs.org
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Please register to the virtual sessions to learn more about our diverse research programs.
Bernhard Research @ CMU
@bernlab26 Oct 2022
Virtual Information Session!
Our website is officially live now! Check it out by clicking link below to find more about our symposium! cmugsspc.org
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Excited about this facility at @CmuScience Cloud labs: where robots do the research nature.com/articles/d41586-0…

Cloud labs: where robots do the research

Nature - A host of companies provide a remote, automated workforce for conducting experiments around the clock.

nature.com
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Excited to share my lab’s first paper online today at Science. So proud of my team @JRui7001 @qun_zhao @ajhuls1 @noelnehc It was great fun to collaborate with Guo Group @MossbauerLab at CMU and Garcia-Borràs Group @MarcGBQ at IQCC-UdG on this project! science.org/doi/10.1126/scie…

Directed evolution of nonheme iron enzymes to access abiological radical-relay C(sp3)−H azidation

Engineered nonheme iron enzymes perform enantioselective radical azidation on aryl N-fluoroamide substrates.

science.org
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Congratulations, Kris!
National Academy of Sciences@theNASciences29 Apr 2022
In recognition of his contributions to polymer and materials chemistry, Krzysztof Matyjaszewski of @MatyPolymerLab @CarnegieMellon @CMU_Chem is being inducted into the National Academy of Sciences. Watch #NAS159: ow.ly/yiMg50IV6Vn #materialsscience #chemistry
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