@MordesLab

Integrating neuropathology, stem cells, and multi-omics to study neurodegeneration #ALS #dementia @UCSFPath @INDUCSF 🧠🔬🌻

 San Francisco, CA
mordeslab.ucsf.edu/
Joined February 2022
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Huge congrats to @JulieSmeyers for being awarded a Springboard Fellowship from Target ALS! targetals.org/2025/12/08/spr…
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Excited to share our @CellReports article! We investigated how the loss of TBK1 function contributes to ALS and dementia using human stem cell-derived neurons and advanced proteomics. Many thanks to all co-authors for their great work and collaboration! sciencedirect.com/science/ar…
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Regulation of translation elongation and integrated stress response in heat-shocked neurons: Cell Reports cell.com/cell-reports/fullte…
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Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing: nature.com/articles/s41467-0… – at Philadelphia, PA

Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome...

Nature Communications - Here the authors identify TNIP1 as a risk factor for a fatal neurodegenerative disorder and discover specific genetic loci associated with the three main subtypes of this...

nature.com
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In this study, we observed that a C9ORF72-ALS/FTD dipeptide repeat protein perturbs the phosphorylation of RNA binding proteins and STMN2 expression, and found that SRSF7 sustains STMN2 levels in induced neurons. Congrats to @JulieSmeyers and Karen! #ALS actaneurocomms.biomedcentral…

C9ORF72 poly-PR disrupts expression of ALS/FTD-implicated STMN2 through SRSF7

Acta Neuropathologica Communications - A hexanucleotide repeat expansion in C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and...

link.springer.com
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Excited to share new study from the lab, work led by @JohnPAndrews_MD and grateful for all the collaborators who made this possible including @ChangLabUcsf @ucscgenomics
UCSF Neurosurgery@NeurosurgUCSF15 Nov 2024
Today in @NatureNeuro, researchers led by @LabNowakowski, @ChangLabUCSF & Mircea Teodorescu (@ucscgenomics) demonstrate the first use of optogenetics to modulate seizure activity at the network level in human brain tissue: nature.com/articles/s41593-0… @JohnPAndrews_MD @UCSFstemcell
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Inhibition of RNA splicing triggers CHMP7 nuclear entry, impacting TDP-43 function and leading to the onset of ALS cellular phenotypes cell.com/neuron/fulltext/S08…

Inhibition of RNA splicing triggers CHMP7 nuclear entry, impacting TDP-43 function and leading to...

Al-Azzam et al. reveal that SmD1, a member of the SMN complex, regulates CHMP7 translocation. Reduced SmD1 expression in sporadic ALS leads to CHMP7 nuclear translocation, while overexpression...

cell.com
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Had a great time at the Oktoberfest IND collaboration hour! Thanks to everyone who stopped by.
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Mordes Lab retweeted
FrattaLab@FrattaLab4 Oct 2024
Out @ScienceMagazine! New tech to activate ALS gene therapies only in the right cells at the right time - Increased safety to have more options for ALS. We do it by taking advantage of cryptic splicing. science.org/doi/10.1126/scie… @UCLIoN @TheCrick @OscarWilkins16 @MaxZYJChien

Creation of de novo cryptic splicing for ALS and FTD precision medicine

Loss of function of the RNA-binding protein TDP-43 (TDP-LOF) is a hallmark of amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders. Here we describe TDP-REG, which exploits the...

science.org
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Excited to announce new funding from the NIA to investigate the connection between defects in protein homeostasis and neurodegeneration. #FTD #dementia #ALS
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Had a lot of fun at lab lunch! Welcome to the lab, Nicole and Lisa!
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Deciphering Distinct Genetic Risk Factors for FTLD-TDP Pathological Subtypes via Whole-Genome Sequencing medrxiv.org/content/10.1101/…

Deciphering Distinct Genetic Risk Factors for FTLD-TDP Pathological Subtypes via Whole-Genome...

Frontotemporal lobar degeneration with neuronal inclusions of the TAR DNA-binding protein 43 (FTLD-TDP) is a fatal neurodegenerative disorder with only a limited number of risk loci identified. We...

medrxiv.org
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The Target ALS #DataEngine just got bigger! We’ve expanded datasets across all core collections, added a user manual, and released new demo videos. Now it’s easier than ever to explore and utilize rich data for #ALSResearch. Explore the updates: bit.ly/3yVk2GF
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Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusions: Neuron cell.com/neuron/fulltext/S08…

Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of...

Intracellular proteinaceous inclusions in neurodegeneration are heterogeneous. Lam, Ndayisaba, et al. developed an iPSC toolbox to rapidly induce CNS cells with inclusions. α-Synuclein “inclusionop...

cell.com
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Excited to finally share work from a past life! In this small study we dissect neuronal vulnerability, myelin dysfunction and microglia activation in #ALS read our full work on @NatureAging nature.com/articles/s43587-0…

Single-nucleus sequencing reveals enriched expression of genetic risk factors in extratelencephalic...

Nature Aging - Using single-nucleus RNA sequencing data from patients with sporadic amyotrophic lateral sclerosis (ALS) cortices, the authors find that higher expression of ALS risk genes is...

nature.com
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Check out the data that goes along with our new manuscript & conduct an exciting secondary analysis of your own! @RCFNeuro @alzdemjournals
Alzheimer's Disease Data Initiative@AlzData18 Jun 2024
New data from the @YokoyamaLabUCSF and @UCSFmac is now available on AD Workbench. Researchers can use this dataset to identify novel disease associations, cell-specific impacts, and therapeutic targets for Alzheimer’s. Access data via AD Workbench: bit.ly/45C3zmA
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Exciting study from the Gitler Lab: TDP-43 nuclear loss in FTD/ALS causes widespread alternative polyadenylation changes biorxiv.org/content/10.1101/…

TDP-43 nuclear loss in FTD/ALS causes widespread alternative polyadenylation changes

In frontotemporal dementia and amyotrophic lateral sclerosis, the RNA-binding protein TDP-43 is depleted from the nucleus. TDP-43 loss leads to cryptic exon inclusion but a role in other RNA proces...

biorxiv.org
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Really excited about our latest preprint, where we uncovered a neuroprotective role for neuronal polyunsaturated fatty acids in FTD and ALS. Led by @AshlingGiblin and @AlexCammack biorxiv.org/cgi/content/shor… 1/9
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Are you an incoming UCSF grad student interested in doing research in neurodegeneration? If you are, join us at the IND OPEN HOUSE @ Helen Diller on 11/15 to meet our current trainees and faculty and to discuss their research! Register here: forms.gle/sqTX5GLNoHiGymQJA
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Win the IND pumpkin carving contest 2 years in a row - ✅ Congrats to the team! @TaylorHWatanabe @JulieSmeyers @LinYadanar_31
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