Mordes Lab retweeted
Regulation of translation elongation and integrated stress response in heat-shocked neurons: Cell Reports cell.com/cell-reports/fullte…
Mordes Lab retweeted
Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing: nature.com/articles/s41467-0… – at Philadelphia, PA
Mordes Lab retweeted
Excited to share new study from the lab, work led by @JohnPAndrews_MD and grateful for all the collaborators who made this possible including @ChangLabUcsf @ucscgenomics
Today in @NatureNeuro, researchers led by @LabNowakowski, @ChangLabUCSF & Mircea Teodorescu (@ucscgenomics) demonstrate the first use of optogenetics to modulate seizure activity at the network level in human brain tissue:
nature.com/articles/s41593-0…
@JohnPAndrews_MD @UCSFstemcell
Mordes Lab retweeted
Inhibition of RNA splicing triggers CHMP7 nuclear entry, impacting TDP-43 function and leading to the onset of ALS cellular phenotypes
cell.com/neuron/fulltext/S08…
Mordes Lab retweeted
Out @ScienceMagazine! New tech to activate ALS gene therapies only in the right cells at the right time - Increased safety to have more options for ALS.
We do it by taking advantage of cryptic splicing.
science.org/doi/10.1126/scie…
@UCLIoN @TheCrick @OscarWilkins16 @MaxZYJChien
Mordes Lab retweeted
The Target ALS #DataEngine just got bigger!
We’ve expanded datasets across all core collections, added a user manual, and released new demo videos. Now it’s easier than ever to explore and utilize rich data for #ALSResearch.
Explore the updates: bit.ly/3yVk2GF
Mordes Lab retweeted
Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusions: Neuron cell.com/neuron/fulltext/S08…
Mordes Lab retweeted
Excited to finally share work from a past life! In this small study we dissect neuronal vulnerability, myelin dysfunction and microglia activation in #ALS read our full work on @NatureAging
nature.com/articles/s43587-0…
Mordes Lab retweeted
Check out the data that goes along with our new manuscript & conduct an exciting secondary analysis of your own! @RCFNeuro @alzdemjournals
New data from the @YokoyamaLabUCSF and @UCSFmac is now available on AD Workbench. Researchers can use this dataset to identify novel disease associations, cell-specific impacts, and therapeutic targets for Alzheimer’s.
Access data via AD Workbench: bit.ly/45C3zmA
Mordes Lab retweeted
Really excited about our latest preprint, where we uncovered a neuroprotective role for neuronal polyunsaturated fatty acids in FTD and ALS. Led by @AshlingGiblin and @AlexCammack biorxiv.org/cgi/content/shor… 1/9
Mordes Lab retweeted
Are you an incoming UCSF grad student interested in doing research in neurodegeneration? If you are, join us at the IND OPEN HOUSE @ Helen Diller on 11/15 to meet our current trainees and faculty and to discuss their research!
Register here: forms.gle/sqTX5GLNoHiGymQJA
Mordes Lab retweeted
Paper 1 by @MathysHansruedi #VernaZhuyuPeng #CarlesBoix et al reports the largest single-cell atlas of #AD to date, across 2.3 million #scRNA cells and 427 post-mortem samples from #ROSMAP AD and non-AD donors, and reveals selectively vulnerable #somatostatin inhibitory neuron subtypes, epigenomic organization changes in #cohesin, #DNAdamage response factors, and specific inhibitory neuron signatures of #resilience
cell.com/cell/fulltext/S0092…
Mordes Lab retweeted
Check out our new preprint on generation and characterisation of C9orf72 polyGR and polyPR knock-in mice. A huge effort over many years by @milioto_carmelo and many collaborators incl. @marcaurelbusche @soyonhonglab
biorxiv.org/cgi/content/shor… 1/5
Mordes Lab retweeted
TDP-43-stratified single-cell proteomic profiling of postmortem human spinal motor neurons reveals protein dynamics in amyotrophic lateral sclerosis biorxiv.org/content/10.1101/…
Mordes Lab retweeted
Excited to release our cell type atlas of the adult mouse brain! Here’s our portal:
braincelldata.org
And preprint:
biorxiv.org/content/10.1101/…
We find minimal marker sets for all cell types, explore activity-regulated genes, and perform analyses of heritability enrichment.
Mordes Lab retweeted
Six years ago I was told to prepare to die.
This is the improbable, inspiring, love-filled, hope-filled, true story about the extraordinary campaign that happened next.
This is where you come in: please share this trailer with everyone so that we can bring hope to everyone.
Mordes Lab retweeted
I’m thrilled to announce that our collaborative study to identify KOLF2.1J as a reference “C57Bl/6J-like” human induced pluripotent stem cell (iPSC) line is finally out in Cell Stem Cell (bit.ly/3B0ncXp)! 🧵
Mordes Lab retweeted
Excellent review of human stem cell strategies and models for ALS and Neurodegenerative disease by the amazing Francesco Limone @CescoLime and @MordesLab. PS Keep an eye on Francesco who will soon be starting a postdoc with @LiddelowSA @ NYU
Recently published in @FrontiersIn: Pluripotent #stemcell strategies for rebuilding the human brain @CescoLime @MordesLab frontiersin.org/articles/10.…
Mordes Lab retweeted
Two FTD-ALS genes converge on the endosomal pathway to induce TDP-43 pathology and degeneration: science.org/doi/10.1126/scie…
