@Meng2Fu

AssistProf @berkeleyMCB Myelin, microtubules, Golgi outposts, RNA transport. Prev: PI @NIH, Barres Lab @Stanford, Holzbaur Lab @Penn, UG @Caltech. Personal acct

 Berkeley, CA
fulab.squarespace.com
Joined September 2018
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Excited to share our new pre-print collab w. @RDasLab! Study led by @VedTopkar brilliant MD/PhD student who used biochemistry and bioinformatics to probe the relationship between Mbp mRNA structure & transport/local translation in oligodendrocytes! biorxiv.org/content/10.1101/… 1/8

RNA switch model for localization and translation of the myelin basic protein mRNA

Oligodendrocytes myelinate the central nervous system by extending cellular projections that ensheath axons and elongate to form lipid-rich myelin. Classic studies visualizing RNA dynamics showed...

biorxiv.org
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Combined w. work from Jackie Trotter & Doug Fields Labs, we propose a RNA switch model: - During transport, hnRNP-F binds unstructured MLS to inhibit translation. - At the cell periphery, membrane-bound Fyn kinase phosphorylates & releases hnRNP-F to initiate translation. 7/8
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It was fantastic to work w. Ved & Rhiju! Ved was incredibly productive & received a R21 for this work. This was a project that survived COVID, 2 lab moves, sabbatical... We're fortunate & grateful to @ZucheroLab Brad for help w. oligo cultures after I left Stanford 🙏 8/8
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Excited to share our preprint on cytoskeletal organization in astrocytes! biorxiv.org/content/10.1101/… Postdoc @mewynne759 looked at microtubules, IFs/GFAP & actin along long elaborate processes. Wonderful to collaborate w postdoc @dharshinigopal & @NogalesLab on cryo-ET 🤓 1/x

Spatially patterned cytoskeletal organization shapes astrocyte branch complexity

Astrocytes, the most abundant cells in the brain, extend elaborate branches that enable diverse functions, from synapse maintenance to blood-brain-barrier integrity. The cytoskeletal basis of this...

biorxiv.org
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Many distal ends are enriched in GFAP. We don't know what this means yet - maybe these can become endfeet that contact blood vessels. Astrocyte processes are heterogeneous in vivo (some contact blood vessels, others contact synapses) - like axons vs. dendrites in neurons. 7/x
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So this preprint opens up many new questions in astrocyte cell biology! This was a real team effort: - Postdoc Will Barclay started the project at the NIH - Postbac Johanna Bergstrom and undergrad Eva Lopez analyzed data - PhD student Lana Ho contributed imaging data
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You can support the next generation of myelin scientists by funding the Myelin Gordon Research Seminar: my.grc.org/p/contributions/1…. @ubhjkri @MS_Focus @mssociety @NeuroForuMS @SfNtweets @GlialInitiative
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Hard to quit this app because I need the cute animal videos! Any colleagues in Scotland seeing this and want to invite me to give a talk? ☺️
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🗓️ Mark your calendar! Join JCB special session at #CellBio2024 with an excellent panel of speakers: @s__ellis, @LabFriedman, @Meng2Fu, @BinyamMogessie, Andrew Muroyama, moderated by @oegemadesai_lab and @timisstuck! See more info 👉 hubs.la/Q02WF1Mn0
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Another issue here is the gap time between bachelors and starting a PhD. At 27, trainees could and should be finishing a 5-year PhD and moving forward in their careers. PhD programs need to normalize accepting students straight out of undergrad.
The PhD Place
@ThePhDPlace3 Nov 2024
We’re all thinking it
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