@MaxFottner

Postdoc in the @klanglab at ETH Zurich. Trying to shed light on the ubiquitin system using chemical biology.

 München, Bayern
Joined February 2019
  • Tweets118
  • Following458
  • Followers276
4Media
Peptide passports: Programmable import fuels novel protein building blocks dlvr.it/TPv3X7
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New paper today in @ScienceMagazine shows Nudix hydrolase 5 protein binds adenosine, making some people sensitive to some chemo drugs. Maybe it binds NAD too, and this could desensitize patients to the toxicity science.org/doi/10.1126/scie…

A non-enzymatic role of Nudix hydrolase 5 in repressing purine de novo synthesis

Folate metabolism is intricately linked to purine de novo synthesis through the incorporation of folate-derived one-carbon units into the purine scaffold. By investigating chemical and genetic...

science.org
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Max Fottner retweeted
nature
@Nature21 Oct 2025
Nature research paper: Hijacking a bacterial ABC transporter for genetic code expansion go.nature.com/3J2iTSE

Hijacking a bacterial ABC transporter for genetic code expansion

Nature - Bacterial ATP-binding cassette (ABC) transporters can be utilized and engineered to transport non-canonical amino acids into Escherichia coli for highly efficient synthesis of proteins...

nature.com
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Max Fottner retweeted
Kathrin Lang@klanglab27 Sep 2024
Happy that this is finally online! Genetic code expansion approaches to decipher the ubiquitin code @ACSChemRev Many congratulations to Vera, Max and Marco! @VeraWanka @MaxFottner @MarkoCigler 🥂🎉🥳 pubs.acs.org/doi/10.1021/acs…
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Thank you @GCEcenter @klang @AChemSynBio for the opportunity to share our work and hear what's happening with genetic code expansion at #GCE2024. And what a finish to the evening! 😎
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Proud to see our 'detective story' on uncovering the MoA of Orpinolide published in its final form in @nchembio! Immensely grateful to @georg_e_winter, the Waldmann lab @mpimoph and @laraialab for being part of this fantastic collaboration!
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I'm happy to share our News & Views article featured in @NatureChemistry, highlighting the excellent work on site-specific incorporation of glutarylated and succinylated lysine residues into multidomain proteins via genetic code expansion by @klanglab! nature.com/articles/s41557-0…

Reversing the charge of lysine by genetic code expansion

Nature Chemistry - Posttranslational modifications alter the structure and function of proteins. Now, genetic code expansion enables encoding of ε-N-succinyllysine and ε-N-glutaryllysine...

nature.com
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Check out our new paper @NatureChemistry where we use microfluidics to identify a mini enzyme from a de novo designed library giving a plausible scenario for emergence of enzymatic function at #OriginOfLife by #DirectedEvolution! nature.com/articles/s41557-0…

Selection of a promiscuous minimalist cAMP phosphodiesterase from a library of de novo designed...

Nature Chemistry - Evolution separates complex modern enzymes from their hypothetical simpler early ancestors, which raises the question of how unevolved sequences can develop new functions. Here a...

nature.com
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Max Fottner retweeted
Kathrin Lang@klanglab25 Apr 2024
Very excited to co-organize GCE2024 with @AChemSynBio and @Mehl_lab at @GCEcenter! Come to Corvallis, Oregon to hear about the newest in genetic code expansion! We have a stellar speaker lineup from academia and industry!👇 Retweet and register! gceconferences.org/

GCE Conferences from Oregon State University

Online GCE

gceconferences.org
Abhishek Chatterjee@AChemSynBio25 Apr 2024
🚨🚨All genetic code expansion enthusiasts, don’t miss the GCE 2024 conference this summer (gceconferences.org/)! Fantastic speakers both from academia and industry. Please retweet! @klanglab @Mehl_lab
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Biocatalysts make chemical industry more sustainable but engineering enzymes is too slow! Check out our preprint @hollfelderlab where we show how microfluidics & AI can help: We rapidly sequence-function profile an IRED in microdroplets and use AI to accelerate its engineering⚡️
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Max Fottner retweeted
Kathrin Lang@klanglab29 Mar 2024
Genetically encoding negatively charged lysine PTMs succinylation/glutarylation and studying their funcional roles! Great team effort by first authors @ML_Jokisch and @Maria_Weyh! Congrats @Maria_Weyh @ML_Jokisch @MaxFottner and Anh! 🥳🤩🙌👨‍🔬🧑‍🔬 @klanglab nature.com/articles/s41557-0…
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Check out our latest preprint @hollfelderlab presenting a versatile cascade for enzyme screening in microfluidic droplets! We hope coupled assay like this will make microfluidics more accessible reducing cost and speeding up sustainable biocatalyst discovery timelines 🌱⏰
Matt Penner@mattpennerKY24 Nov 2023
Really excited to share the most recent preprint from the @hollfelderlab, a new fluorescence assay for NAD(P)H quantification that helps to bridge the gap between plate and droplet screening for enzymes with @MaxGantz_ and Jamie Klein. (biorxiv.org/content/10.1101/…). When applying

Sub-single-turnover quantification of enzyme catalysis at ultrahigh throughput via a versatile...

Enzyme engineering and discovery are crucial for a future sustainable bioeconomy, and harvesting new biocatalysts from large libraries through directed evolution or functional metagenomics requires...

biorxiv.org
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Max Fottner retweeted
Kathrin Lang@klanglab18 Sep 2023
We have a new doctor in the @klanglab! Well done to Kristina - Dr. Krauskopf - who successfully defended her thesis!🎓🥳👏 Many thanks to @SieberLab and Hubert Gasteiger for being on the committee at TUM! Very sorry for only being present via Zoom and missing the party fun 🤒🦠🙄
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Amazing virtual talk by @klanglab at #ESBOC56 @ESBOC_Gregynog. She talked about her group's work on expanding the functions of proteins with non-canonical amino acids. Great applications in bioconjugations, crosslinking and defined ubiquitin conjugates. nature.com/articles/s41467-0…

A modular toolbox to generate complex polymeric ubiquitin architectures using orthogonal sortase...

Nature Communications - Ubiquitin (Ub) and Ub-like modifiers (Ubls) can form chains of various topologies, but preparing defined chains for functional studies remains challenging. Here, the authors...

nature.com
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I am looking for a #Postdoc! Do you have #molecular_biology experience and are excited about developing top edge #drug_discovery modalities in a young team pomplunlab.com/open-position…? Join us @LACDR @LeidenScience Please RT! nature.com/naturecareers/job…

Open positions

There is a labcoat waiting for YOU Bachelor & Master StudentsWe have several exciting M.Sc. projects available. The projects are in the field of early drug discovery and you will learn and appl…

pomplunlab.com
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Replying to @ERC_Research
@ERC_Research funded #postdoc position in my group We are looking for a molecular biologist excited to help developing synthetic tools that can control gene transcription. @UniLeiden @LACDR @LeidenScience Please RT!!! And apply :-) universiteitleiden.nl/en/vac…
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Max Fottner retweeted
Kathrin Lang@klanglab19 Jul 2022
Check out our new paper for site-specific labeling proteins and building defined Ub/Ubl-protein conjugates using a plant Asp-endopeptidase. Great effort by @MaxFottner @jhmgrtnr @MaxGantz_ @RaMue1304 and @NkTimon! Congratulations to all!👩‍🔬👨‍🔬🤩🙌🥳
J. Am. Chem. Soc.@J_A_C_S19 Jul 2022
Site-Specific Protein Labeling & Generation of Defined Ubiquitin-Protein Conjugates Using an Asparaginyl Endopeptidase @ETH_DCHAB @ETH_en @klanglab @TU_Muenchen @MaxFottner #SiteSpecific #ProteinLabelling #Ubiquitin #Conjugates #Asparaginyl #Endopeptidase pubs.acs.org/doi/10.1021/jac…

Site-Specific Protein Labeling and Generation of Defined Ubiquitin-Protein Conjugates Using an...

Abstract. Asparaginyl endopeptidases (AEPs) have recently been widely utilized for peptide and protein modification. Labeling is however restricted to prot

pubs.acs.org
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Site-Specific Protein Labeling & Generation of Defined Ubiquitin-Protein Conjugates Using an Asparaginyl Endopeptidase @ETH_DCHAB @ETH_en @klanglab @TU_Muenchen @MaxFottner #SiteSpecific #ProteinLabelling #Ubiquitin #Conjugates #Asparaginyl #Endopeptidase pubs.acs.org/doi/10.1021/jac…

Site-Specific Protein Labeling and Generation of Defined Ubiquitin-Protein Conjugates Using an...

Abstract. Asparaginyl endopeptidases (AEPs) have recently been widely utilized for peptide and protein modification. Labeling is however restricted to prot

pubs.acs.org
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Max Fottner retweeted
D-CHAB@ETH_DCHAB30 May 2022
Sometimes we must create artificial things to understand nature. Kathrin Lang @klanglab, new professor of #ChemicalBiology #LOC, develops special tools and enables deep insights into complex biological systems. Learn more on June 1 #inaugurallecture & on chab.ethz.ch/en/news-and-eve…
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Join us as a postdoc at the amazing @mpi_nat: mpinat.mpg.de/3895934/26-21

Stellenangebote

mpinat.mpg.de
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