@PomplunSeb
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Chemist. Dad. Assistant Professor @LeidenScience @LACDR. Drug Discovery - Novel Chemical Modalities - Combinatorial Chemistry https://nitter.cf/t.co/3VBwFtKIAz
Boston, MA
Joined June 2019
- Tweets908
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- Followers1.4K
- Likes3.1K
Sebastian Pomplun retweeted
📢 JOB ALERT 📢
My team @molecularML is searching for a #postdoc with a background in medicinal chemistry! 👩🔬👨🔬🧪
Do you have the experience?
Are you eager to contribute to #AI for discovering new drugs?
👉Then DM me!
Funded by @ERC_Research and located at @TUeindhoven 🚀
Sebastian Pomplun retweeted
We had a small change in the program. The @LED3hub Lecture by Paola Picotti @Picotti_Lab was moved to February 6th, 2025.
This week we are kicking of the @LED3hub Lectures of this academic year. We are very excited to again have an amazing lineup. If you are interested , you are very much invited to join us in Leiden for these exciting lectures. universiteitleiden.nl/en/sci…
Sebastian Pomplun retweeted
Thrilled to share our latest work on the late-stage, site-specific chemical insertion of aromatic PTMs into proteins, published today in @J_A_C_S
A big thanks to @LashuelLab for the exciting collaboration. Congratulations to Lin, Shaswati, and the team!
pubs.acs.org/doi/10.1021/jac…
Sebastian Pomplun retweeted
Come join us at EPFL! We are looking to fill a new position for a Tenure Track Professor in Chemical Biology! Find all info how to apply here: epfl.ch/about/working/page-2…
Sebastian Pomplun retweeted
Can you simultaneously improve the potency and safety profile of a clinically used antibiotic?
The group of @NatMart_Chembio of the @LED3hub presents the guanidino lipoglycopeptide antibiotic class with potent antibacterial activity in @ScienceTM.
science.org/doi/10.1126/scit…
Sebastian Pomplun retweeted
Amazing news that two projects involving @LED3hub scientists have been awarded funding through @NWOFunding Open Competition M2 grants. Congratulations to @PomplunSeb and Matthias Barz from the @LACDR as well as Sander van Kasteren from the LIC.
nwo.nl/en/news/twenty-one-in…
Sebastian Pomplun retweeted
A focused library of site-specifically acetylated Max transcription factor analogs was chemically synthesized to dissect the role of Lys-acetylation in its DNA binding activity
NEW #ASAP by @jbaram90 @afek7afek
Read it here: go.acs.org/a9D
Sebastian Pomplun retweeted
MC4DD: New EU consortium on drug discovery dedicated to macrocycles. 8 universities and 6 industry partner join forces to advance the science of macrocycles as drugs. More information: MC4DD.com
Sebastian Pomplun retweeted
Can you improve an antibiotic that has been in clinical use for 75 years?
The group of @NatMart_Chembio of the @LED3hub addressed this question by developing bacitracin analogs with enhanced activity against vancomycin-resistant enterococci (VRE).
pnas.org/doi/10.1073/pnas.23…
Sebastian Pomplun retweeted
Our latest paper is just out in ACS Chemical Biology. Novel quenched fluorescent activity-based probes for serine proteases based on phosphinate esters. This work was part of the PhD of @KahlerJp. pubs.acs.org/doi/10.1021/acs…
Sebastian Pomplun retweeted
Great paper from the groups of @J_McGouran and Sander van Kasteren with first author @SeanMcK27 in @rsc_chembio. Fully-functionalized probes based on the metal chelator 8-mercaptoquinoline for affinity-based protein profiling of metal-binding proteins. doi.org/10.1039/D4CB00053F
Sebastian Pomplun retweeted
LED3’s first PhD/Postdoc symposium was a big success!🎉 Researchers from different Leiden Science institutes presented their interdisciplinary research on Early Drug Discovery.
Read more about the collaboration: universiteitleiden.nl/en/sci…
#LED3Symposium
Sebastian Pomplun retweeted
At the #LED3Symposium, we also announced next year's #LED3Lectures with an amazing program including @BalskusLab, Andrew Leach, Tjeerd Barf, @Picotti_Lab, @RentmeisterLab, Jeff Kelly, @johnpoverington, Kim Lewis, @TateScience and @jaykeasling.
Sebastian Pomplun retweeted
It was great to see all the lively discussions between researchers from all of our institutes at the poster session of the #LED3Symposium. We had a very high quality of posters with an amazing diversity of topics and a lot of interdisciplinary connections.
Sebastian Pomplun retweeted
Great talk by Bert Beerkens at the #LED3Symposium. He talked about his research on the development of labeling reagents for the adenosine A2B receptor using ligand-directed chemistry. Interesting application of N-acyl-N-alkyl sulfonamide (NASA) chemistry.
Sebastian Pomplun retweeted
Great talk by Sophie Wintermans at the #LED3Symposium. She talked about her PhD research in the group of @Martola1985 into a high throughput screening method for RNA-binding small molecules on the example of the PreQ1 riboswitch. biorxiv.org/content/10.1101/…
Sebastian Pomplun retweeted
The final keynote lecture of the #LED3Symposium was given by @NatMart_Chembio. He talked about his group's amazing research into inhibitors of the cancer driver protein Nicotinamide N-methyltransferase (NNMT). sciencedirect.com/science/ar…
Sebastian Pomplun retweeted
Great talk by Nataliia Machushynets at the #LED3Symposium. She talked about her research in the group of @GillesvanWezel into new tridecaptin antibiotics with enhanced biological activity. An exciting interdisciplinary project across several @LED3hub groups.
Sebastian Pomplun retweeted
Great science at the Flash Talk session of the #LED3Symposium. Amazing to see all the diverse topics including antibiotics, cyclic peptides, GPCRs, genome mining, hydrogels, covalent inhibitors and many more that are covered in interdisciplinary projects within the @LED3hub.
