@MSchlapansky
Joined April 2018
  • Tweets222
  • Following246
  • Followers100
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Moritz Schlapansky retweeted
Jacob Corn@jcornlab24 Oct 2025
Ever noticed that #CRISPR editing results differ between cells? Awesome PhD student @MSchlapansky developed "scOUT-seq" to measure single cell transcriptomes + editing. 1.2 million cells, 74 cell types, living 🐭. Cell subtypes differ wildly from bulk! biorxiv.org/content/10.1101/…

Cell-stereotyped DNA repair outcomes are widespread during genome editing

Genome editing outcomes are governed by DNA repair pathways that vary with cell type and state. We developed scOUT-seq (single-cell Outcomes Using Transcript sequencing), a scalable approach that...

biorxiv.org
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Moritz Schlapansky retweeted
Jacob Corn@jcornlab30 Jan 2025
Cells are filled with toxic stuff that damages healthy proteins. Is that garbage just left to rot on the curb? No way! Ubiquitin ligases have evolved to recognize chemical damage and clean it up! nature.com/articles/s41586-0…

C-terminal amides mark proteins for degradation via SCF–FBXO31

Nature - SCF–FBXO31 scans proteins for C-terminal amidation and marks them for subsequent proteasomal degradation.

nature.com
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Moritz Schlapansky retweeted
Jacob Corn@jcornlab4 Oct 2024
I'm looking for a #bioinformatician to join my group! Searching for someone collaborative & self-motivated with expertise in #NGS analysis. For example, functional genomics, #singlecell, splicing, RNA binding, lineage barcoding, ChIP-seq. Apply at jobs.ethz.ch/job/view/JOPG_e…
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Moritz Schlapansky retweeted
Alex Lercher@alex_lercher1 Oct 2024
How do past viral infections influence future viral diseases? We found that SARS-CoV-2 recovery protected from severe influenza A virus disease. But how come? There seemed to be some antigen-independent immunological memory going on.. Paper @ImmunityCP: authors.elsevier.com/c/1js3h…
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Moritz Schlapansky retweeted
Julia S. Brunner@jules_stef5 Jan 2024
Thank you @NatureComms for publishing my first paper and asking me about the slightly turbulent back story! nature.com/articles/s41467-0…
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Moritz Schlapansky retweeted
Alex Plesa@amplesa21 Dec 2023
Can we reverse aging? 7 yrs ago, Ocampo et al. showed that partial reprogramming can ameliorate aging hallmarks. But, OSKM induction has safety limitations & no new factors have emerged since. Here, biorxiv.org/content/10.1101/… we used 🧬 screens to find new rejuvenation factors🧵1/8
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Moritz Schlapansky retweeted
Philipp Fisch@fisch_philipp5 Oct 2023
Ever wondered about combining 2 tissue engineered grafts? 💭Check out our latest publication in which we combine tissue engineered skin and cartilage for ear reconstruction!👂🏻 @ZenobiWongLab @AgnesKlar science.org/doi/10.1126/scia… @ScienceAdvances #ScienceAdvancesResearch

Combining bioengineered human skin with bioprinted cartilage for ear reconstruction

A therapy for microtia patients utilizes bioprinted auricular cartilage combined with a tissue-engineered skin graft.

science.org
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Moritz Schlapansky retweeted
Lukas Schmidheini@LSchmidheini21 Sep 2023
Today we @schwanklab report in @nchembio a PACE-evolved, PAM-relaxed, compact Cas9 enzyme. evoCjCas9 supports base- and prime editing, and, owing to its small size, can be delivered on single AAV vector systems. nature.com/articles/s41589-0… @UZH_Science @ETH_en (1/6)
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Moritz Schlapansky retweeted
Antonio Santinha@AntonioSantinha20 Sep 2023
🚨🚨🚨 Ever wanted to do in vivo single-cell CRISPR screens but don’t know where to start? Then check our latest publication @Nature introducing AAV-Perturb-seq. nature.com/articles/s41586-0… 1/🧵

Transcriptional linkage analysis with in vivo AAV-Perturb-seq

Nature - An in vivo single-cell CRISPR screening method identifies transcriptional phenotypes of 22q11.2 deletion syndrome associated with a broad dysregulation of a class of disease susceptibility...

nature.com
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Congrats, Dr. @DerGenger!! Well done. As PI, it remains a special and humbling experience to see a PhD student defend. 🦠 🌈 🙏 #virus #immunology #immunometabolism #epidemiology #phdchat #PIchat @Bergthalerlab @MedUni_Wien @CeMM_News @oeaw #Vienna
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Moritz Schlapansky retweeted
Jacob Corn@jcornlab21 Aug 2023
Genetic interactions reveal unexpected biology and can lead to novel therapeutics (e.g. #Olaparib). In a new preprint, John Fielder and @SMSiegner w/ @CejkaLab comprehensively unravel *all* genetic interactions in the human DNA damage response! biorxiv.org/content/10.1101/… 🧵

Comprehensive Interrogation of Synthetic Relationships in the Human DNA Damage Response

The DNA damage response (DDR) is a multi-faceted network of pathways that preserves genome stability. Unraveling the complementary interplay between these pathways remains a challenge. Here, we...

biorxiv.org
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Moritz Schlapansky retweeted
Anna Obenauf@obenaufa17 Jul 2023
Ever wondered why hair grows excessively within your moles? Super interesting! 👇
nature
@Nature22 Jun 2023
Nature research paper: Signalling by senescent melanocytes hyperactivates hair growth go.nature.com/46e5Ns9

Signalling by senescent melanocytes hyperactivates hair growth

Nature - Senescent melanocytes of skin nevi drive hyperactivation of hair growth through the signalling factor SPP1.

nature.com
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Moritz Schlapansky retweeted
Jacob Corn@jcornlab30 Jun 2023
Cells degrade unfolded proteins. But do they also check for chemical damage? We found that a C-terminal amide is completely sufficient for degradation by an SCF/FBXO31 ligase complex! With @bode_lab @matthias_muhar @jakobfarnung. biorxiv.org/content/10.1101/… 🧵

C-terminal amides mark proteins for degradation via SCF/FBXO31

During normal cellular homeostasis unfolded and mis-localized proteins are recognized and removed, preventing the build-up of toxic byproducts[1][1]. When protein homeostasis is perturbed during...

biorxiv.org
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Moritz Schlapansky retweeted
Kim Fabiano Marquart
@marquark26 Jun 2023
🎙️Excited to launch my new podcast #CRISPRli, a deep dive into the revolutionary world of #CRISPR. I'll be hosting interviews with top genome editing experts. Ideal for scientists, students or anyone curious about this cutting-edge tech. #GeneEditing open.spotify.com/show/1NDD79… – at Zurich, Switzerland
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Moritz Schlapansky retweeted
Jacob Corn@jcornlab20 Jun 2023
I'm looking for a bioinformatician to join my group! Searching for someone collaborative & self-motivated with expertise in NGS analysis.For example, functional genomics, single-cell, splicing, RNA binding, lineage barcoding, ChIP-seq. Apply at jobs.ethz.ch/job/view/JOPG_e…
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Moritz Schlapansky retweeted
The Bergthaler Lab@Bergthalerlab19 Jun 2023
Open positions for 1 PhD student and 1 Master student in our lab at the @MedUni_Wien in Vienna, Austria The successful applicants will work on advanced #pathogen #surveillance. More details: bergthalerlab.com . #Phdposition #Masterposition #Vienna #Jobs #AcademicChatter
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Moritz Schlapansky retweeted
Poon Lab @ UTEP@ThePoonLab17 Jun 2023
We have a BME/MASE #PhD position open in the lab for Sept 2023! Come join us if you're interested in engineering tools to study nano-bio interactions for nanoparticle-based drug delivery systems! 🔬⚗️🧬💉💊 Deadline for application is July 1st! #newPI – at El Paso, TX
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Moritz Schlapansky retweeted
Hannah@xHannahGhasemi27 Feb 2023
Beyond proud to share the very first paper to come out of the @richardson_lab - what an honor! Special thanks to Chris Richardson (my PI/mentor) and @JulienBacal for pioneering and evolving this project with me. 🧵
Nature Biotechnology
@NatureBiotech27 Feb 2023
Interstrand crosslinking of homologous repair template DNA enhances gene editing in human cells - @mcdbucsb go.nature.com/3YaXTdD
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Moritz Schlapansky retweeted
Ming "Tommy" Tang@tangming200520 Jan 2023
All biology is computational biology. data are omnipresent, learn computational skills and you will be unstoppable. Take 5 mins to bookmark the following threads to guide your learning 👇🧵 journals.plos.org/plosbiolog…

All biology is computational biology

Here, I argue that computational thinking and techniques are so central to the quest of understanding life that today all biology is computational biology. Computational biology brings order into our...

journals.plos.org
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Moritz Schlapansky retweeted
Tanja Rothgangl@tanjarothgangl22 Sep 2022
The SWISSPR 2022 took place during the last 3 days. It was a great experience to meet fantastic scientists from @jcornlab, @MartinJinek, @randall_platt and @schwanklab and learn about their exciting research. Many thanks to our keynote speakers @xecoli (#GEML) and @MartinPacesa!
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