Understand protein structure-function relationships and use this knowledge to answer fundamental questions of chemistry/biochemistry at the University of Otago.
Joined April 2020
- Tweets42
- Following216
- Followers146
- Likes57
Just out: Covalent isothiocyanate inhibitors of macrophage migration inhibitory factor as potential colorectal cancer treatments. Great collaborative effort between @OtagoPharmacy @joel_tyndall , @OtagoBiochemist and @otago Chemistry
doi.org/10.1002/cmdc.2024003…
New @BiochemistryACS paper about one of my favorite enzymes ever - Structural, Spectroscopic, and Computational Insights of the Ethylene-Forming Enzyme. Collaboration between @MSU_BMB @michigantech and myself at @OtagoBiochemist doi.org/10.1021/acs.biochem.…
Structures just released
rcsb.org/structure/8T87
rcsb.org/structure/8T88
determined in collaboration with @Stanford @mbogyo and my lab at @OtagoBiochemist - JACS paper on Probes for Specific Detection of Staph Infections
doi.org/10.1021/jacs.3c13974 @JeyunJo @TulsiUpadhyay5 +others
MatthiasFellner retweeted
Check out our latest covalent probes for imaging Staphylococcus aureus infections published @J_A_C_S. Great work from @JeyunJo and @TulsiUpadhyay5 and collaborators. pubs.acs.org/doi/full/10.102…
MatthiasFellner retweeted
Thrilled to share the news!! Thanks Matt @mbogyo, for giving this fantastic opportunity to work on this project. Enjoyed teaming up with @JeyunJo, @MFellnerLab and all our collaborators 🙌 Thanks @ec_woods, @NikkiPedowitz, @SijieWang5 for helping us with this project!!
Check out our latest covalent probes for imaging Staphylococcus aureus infections published @J_A_C_S. Great work from @JeyunJo and @TulsiUpadhyay5 and collaborators. pubs.acs.org/doi/full/10.102…
MatthiasFellner retweeted
Exciting news from our recent research with @TulsiUpadhyay5 on oxadiazolone-based probes targeting FphE, a S. areus specific serine hydrolase. This is a result of great collaboration with @MFellnerLab, the Valdez lab, Joanna Jaworek-Korjakowska, and the team at @mbogyo lab.
Looking for a new covalent electrophile for serine and cysteine nucleophiles? Check out this great work by @JeyunJo and @TulsiUpadhyay5 developing an oxadiazolone based probe for the S aureus serine hydrolase FphE. biorxiv.org/content/10.1101/…
MatthiasFellner retweeted
Looking for a new covalent electrophile for serine and cysteine nucleophiles? Check out this great work by @JeyunJo and @TulsiUpadhyay5 developing an oxadiazolone based probe for the S aureus serine hydrolase FphE. biorxiv.org/content/10.1101/…
1. characterization of a highly conserved S. aureus serine hydrolase. pubs.acs.org/doi/10.1021/acs…
@OtagoBiochemist (Annabel Walsh) OtagoChemistry (Sutherland, Tan) & international collaborators A. Bakker, @mariovdstelt, @NatMart_Chembio, @NadiaAftab18, S. Dela Ahator @ChristianSLentz
One week left to apply #postdoc #position in #biochemistry on #research into #peptide & #enzyme via #phage in ##infectiousdisease at #university @OtagoBiochemist in #NewZealand and #Shanghai #SIMM
Details: otago.taleo.net/careersectio…
We are looking for a Postdoctoral Fellow to create peptide tools for the treatment & diagnosis of infectious diseases at the University of Otago & Shanghai Institute of Materia Medica.
Funded by New Zealand Maurice Wilkins Centre Starting September
Details otago.taleo.net/careersectio…
We are looking for an Assistant Research Fellow to create Staphylococcus aureus samples for metabolomics to identify the roles of serine hydrolases in biofilms (otago.ac.nz/biochemistry/new…)
University of Otago, Dunedin, New Zealand.
Starting in July
Details: otago.taleo.net/careersectio…
MatthiasFellner retweeted
Bacterial biofilm therapeutics project wins Marsden Fund support ift.tt/Ylq0Vr9
A project investigating new ways to fight deadly bacterial biofilms has won a Marden Fast-Start fellowship for its lead researcher, Otago biochemist Dr Matthias Fellner.
Matthias is seeki…
MatthiasFellner retweeted
Otago researchers set to tackle health issues with Career Development Awards ift.tt/ED3hxJa
From a global health crisis to Aotearoa’s health inequity – University of Otago projects awarded Health Research Council funding will benefit those at home and around the world…
MatthiasFellner retweeted
$3.8 million to Otago researchers in Career Development Awards ift.tt/Zaz9o1D
The Health Research Council has awarded 19 Otago researchers almost $3.8 million in Career Development Awards.
These awards help launch research careers through a wide range of master’s and…
MatthiasFellner retweeted
Taputapu kē! Dr Matthias Fellner🧑🔬 @MFellnerLab @OtagoBiochemist @otago has been awarded a #MarsdenFund Fast-Start to study how #Staphylococcus aureus 🦠 use biofilms in antibiotic 💊 resistant bacteria #infection s🏥. #staph #AntibioticResistance
royalsociety.org.nz/what-we-…
MatthiasFellner retweeted
Really excited to have our paper describing mutations in histone H4 now out - a fantastic collaboration with @GijsvanHaaften and lots of families around the world. Now investigating the mechanism thanks to @MarsdenFund support!
New! Tessadori et al. demonstrate that de novo variants in histone H4 cause a neurodevelopmental disorder
bit.ly/3IgnevO
MatthiasFellner retweeted
Thanks also to @MacePeter for helping with the structural interpretations of these mutations within the nucleosome!
Newly discovered #Staphylococcus aureus serine hydrolase probe and drug targets
pub.iapchem.org/ojs/index.ph…
My latest review of ten S. aureus protein targets for probe & drug development. Looking forward to new advances @mbogyo @ChristianSLentz and myself @OtagoBiochemist.
Excited to share my latest paper in #JournalofLifeSciences on #Cesium binding in #protein #crystals based on work between @MSU_NatSci and @OtagoBiochemist
doi.org/10.36069/JoLS/202103…
Consider #caesium in your #crystallography experiments to improve #diffraction or solve #phases.
Altered structure and dynamics of pathogenic cytochrome c variants correlate with increased apoptotic activity
doi.org/10.1042/BCJ20200793
Our latest work hot off the press from @OtagoBiochemist. Thanks @parakra, KD, @ItamarKass, @gnljameson, SMW & @Liz_Ledgerwood
