Chromatin & Cancer Biologists at Columbia university
New York, NY
Joined October 2017
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Please spread the word and register. Great event for sharing science and building collaboration for NYC epigenetic labs!
Here we go! Excited to share our latest collaborative work with @MichaelMShen and @califano_lab.
We uncovered that NSD2-catalyzed H3K36me2, a histone mark dearest to our lab, is critical for lineage plasticity and resistance to anti-androgen in prostate cancer.
Nature research paper: NSD2 targeting reverses plasticity and drug resistance in prostate cancer
go.nature.com/48oN7Id
While there is still a lot to learn about the underlying mechanism, these findings suggest the therapeutic potential of combining NSD2 inhibitor with AR inhibitor in treating aggressive prostate tumors. A clinical study is already ongoing: clinicaltrials.gov/study/NCT…
Further, recent work from Gozani, Mazur, Majewski and Jaremko labs demonstrates therapeutic benefit of NSD2 inhibitor in preclinical models of lung and pancreatic cancers, suggesting a broad role of H3K36me2 in cancer chromatin plasticity: nature.com/articles/s41586-0…
Lu Lab_Columbia retweeted
Symposium Registration Deadline Friday! - NYC Chromatin Club - mailchi.mp/cbee4a4e6267/regi…
Lu Lab_Columbia retweeted
Registration - NYC Chromatin Club - July 15, 2025 - mailchi.mp/c3d82b17e5c0/regi…
Lu Lab_Columbia retweeted
Want to work with us on DNA methylation and rare genetic disease? Fully funded PhD project with deadline 16th May:
findaphd.com/phds/project/fu…
Excited to collaborate with @Hannah_K_Long and @bunina_daria (@EdinUni_IGC @MDC_Berlin).
Please share 🙏
#epigenetics
Excited to share this review on chromatin-metabolism crosstalk, lead by our star student Varun Sahu. Here, Varun summarizes the molecular principles governing metabolite-chromatin interaction & highlights emerging technologies that could advance the field. There’re lots to learn!
In this review for our focus issue on patterns in molecular biology, @LuLaboratory explores how metabolites and metabolic enzymes regulate chromatin and histone modification patterns, highlighting the crosstalk between the metabolome and the epigenome.
cell.com/molecular-cell/full…
Check out this important work - congrats to KJ, Victoria and the team!
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Lu Lab_Columbia retweeted
Please Repost-
Excited to be recruiting @CeiFccc @FoxChaseCancer #epigenetic #faculty to continue building our energetic, interactive, supportive #collegial environment
Our goal- Basic Discovery & help translate to positively impact patients
Apply here-
jobs.sciencecareers.org/job/…
Here we go - our preprint on the interplay between DNMT3A and polycomb H2AK119Ub mark is published. We believe these findings offer a potential mechanism driving DNA hypermethylation in cancer. Pls see tweetorial for more details. science.org/doi/10.1126/scia…
Excited to share our new preprint on the interaction between DNMT3A1 and H2AK119Ub. This work is the fruit of a collaboration between @LuLaboratory, @KJArmache Lab and @epicypher and co led with @Xagbomson biorxiv.org/content/10.1101/…
Congrats again to @KristjanGretars @Xagbomson Susan Gloor, Dan Weinberg, @KJArmache @GCloner @epicypher and everyone involved! Thanks to the reviewers and editor @ScienceAdvances for improving our manuscript.
Lastly, shoutout to two other papers that characterize the interaction between DNMT3A and H2AK119Ub nucleosome.
nature.com/articles/s41467-0… by Jikui Song and Greg Wang groups.
biorxiv.org/content/10.1101/… by @mdrwilson group.
Lu Lab_Columbia retweeted
What's new and what's next in cancer epigenetics research? Join us for the 2024 VAI Epigenetics Symposium. Our allstar speaker lineup will highlight the latest advances with a focus on mechanisms and therapeutic applications. Registration closes tomorrow!
vai.org/event/vai-epigenetic…
Lu Lab_Columbia retweeted
How to pick a problem. Today in @CellCellPress. 1/53
cell.com/cell/fulltext/S0092…
Please see tweetorial below for the latest from the lab led by @KristjanGretars. In collaboration with @GCloner @KJArmache @Xagbomson, this work reveals molecular details of DNMT3A targeting to polycomb CGIs and its implication for cancer-associated DNA hypermethylation.
Excited to share our new preprint on the interaction between DNMT3A1 and H2AK119Ub. This work is the fruit of a collaboration between @LuLaboratory, @KJArmache Lab and @epicypher and co led with @Xagbomson biorxiv.org/content/10.1101/…
It also implies that perturbing the interaction between DNMT3A-H2AK119Ub could be a potential strategy to prevent or reverse DNA hypermethylation in cancer.
Lu Lab_Columbia retweeted
Free Hybrid World Class Symposium- Featuring Academic and Pharma/Biotech Leaders!
Register asap. >400 registered and counting.
#Epigenetics #3DGenome #Chromatin
@GAlmouzni @KharasLab @METorresPadilla @ranigeorgelab @LuLaboratory @job_dekker @DaiichiSankyoUS @AstraZeneca @CeiFccc
