@RothbartLab

Professor @VAInstitute. Chromatin biochemistry, cancer epigenetics, functional proteomics.

 Grand Rapids, MI
rothbartlab.vai.org/
Joined November 2018
  • Tweets261
  • Following255
  • Followers621
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Scott Rothbart retweeted
Yael David@Yael_David__17 Jul 2025
Big day for the David lab! 🎉 Our @MolecularCell paper is out today- huge congrats to first authors @IfeAkano & Jake Hebert for leading this beautiful study uncovering SMARCA3 as a novel H3 E3 ligase that shapes heterochromatin regulation in colorectal cancer 🤩
Molecular Cell@MolecularCell17 Jul 2025
Online Now: The SWI/SNF-related protein SMARCA3 is a histone H3K23 ubiquitin ligase that regulates H3K9me3 in cancer dlvr.it/TLz0Lw
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A person’s lifetime risk for #cancer may begin before they are even born, reports a paradigm-shifting study by Van Andel Institute scientists published in @NatureCancer. @PospisilikJ @Bi0lilla vai.org/cancer-risk-developm…
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Thrilled to share the results @Cancer_Cell of years of hard work to develop classifiers for all major TCGA cancer subtypes, enabling assessment of differential drug response among cancer subtypes in clinical trials. cell.com/cancer-cell/fulltex…

Classification of non-TCGA cancer samples to TCGA molecular subtypes using compact feature sets

Ellrott et al. provide a means to assign patient samples from clinical trials and other cancer genome studies to published TCGA molecular subtypes. Applying machine learning to data from five...

cell.com
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Scott Rothbart retweeted
Lluis Morey@lluismorey11 Dec 2024
We have postdoc positions open to study epigenetic mechanisms contributing to resistance to chemo+immuno in TNBC, and projects related to epigenetic determinants of neurodevelopmental disorders. Feel free to reach out to me here/via email. Please like and repost!
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Congratulations to Van Andel Institute’s Dr. Peter Jones, VAI and @HopkinsKimmel's Dr. Stephen Baylin, and @HopkinsMedicine's Dr. Andrew Feinberg, who will receive the Harvey Prize for their groundbreaking work in cancer epigenetics! Read more: vai.org/harvey-prize
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Manuscript acceptance (stay tuned) and a new preprint. Pretty good 24hrs for the lab! biorxiv.org/content/10.1101/…

UHRF1 ubiquitin ligase activity supports the maintenance of low-density CpG methylation

The RING E3 ubiquitin ligase UHRF1 is an established cofactor for DNA methylation inheritance. Nucleosomal engagement through histone and DNA interactions directs UHRF1 ubiquitin ligase activity...

biorxiv.org
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This preprint is now published with some key additions guided by an excellent review process @NAR_Open. Also grateful to our collaborators for helping progress this one across the finish line! @suscla1 @qianthefirst @Yael_David__ @zhouwanding and others! academic.oup.com/nar/advance…

UHRF1 ubiquitin ligase activity supports the maintenance of low-density CpG methylation

Abstract. The RING E3 ubiquitin ligase UHRF1 is an established cofactor for DNA methylation inheritance. The model posits that nucleosomal engagement throu

academic.oup.com
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Online Now: DNA hypomethylation promotes UHRF1-and SUV39H1/H2-dependent crosstalk between H3K18ub and H3K9me3 to reinforce heterochromatin states dlvr.it/TGZ732
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Scott Rothbart retweeted
Ayush Raman@aayushraman4 Dec 2024
Congratulations to the authors @RothbartLab, shows the role of UHRF1 in the redistribution of H3K9me3 following DNA hypomethylation, a lingering question in the field and may have implications for the field of aging. cell.com/molecular-cell/full…
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Two new papers from the lab to end the year! Will be posting about them both at the new place in the coming weeks. @rothbartlab.bsky.social Come join us - it’s great! #SciCommBackAgain
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Time to move. See you all on Bluesky: @helink.bsky.social Let's work on getting our respective institutions and our colleagues to move as well. There is an exponential increase in members on Bluesky!! theguardian.com/media/2024/n…
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If you are interested in a faculty position in the heart of metabolism, at one of strongest and most supportive institutes focused on metabolism, epigenetics, neurodegeneration and more, VAI is recruiting at all levels! vai.wd1.myworkdayjobs.com/en…
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Scott Rothbart retweeted
Russell Jones@DrRGJonesLab18 Sep 2024
Great place to post doc @VAInstitute
This Post is from an account that no longer exists. Learn more
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Scott Rothbart retweeted
Kanishk Jain@chromajain1 Aug 2024
Just 2 postdocs from @DrBrianStrahl’s lab (current: me; former: @RothbartLab) with their mentor. Looking forward to joining Scott on the former postdoc/current PI list by the next #BioMethylSRC
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Scott Rothbart retweeted
Yael David@Yael_David__13 Jun 2024
Registration is still open for this super exciting meeting! ⭐️Unbelievable lineup of #epigenetics & #aging speakers ⭐️Opportunities for short talks ⭐️New pre-meeting dedicated to trainees w/ extra opportunities for career development & 1:1 with PIs ⭐️Special awards available!
Yael David@Yael_David__12 Mar 2024
Excited to be organizing my first international conference w/@petertessarz @TheWebbLab & @Morrison_Lab_SU on #epigenetic & #aging & everything in between! Amazing speakers (keynotes @BrunetLab @MAF_Dawson @OdedRechavi) & a new opportunity for trainees⬇️ events.faseb.org/event/a7662…
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What's new and what's next in cancer epigenetics research? Join us for the 2024 VAI Epigenetics Symposium. Our allstar speaker lineup will highlight the latest advances with a focus on mechanisms and therapeutic applications. Registration closes tomorrow! vai.org/event/vai-epigenetic…
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Registration closes May 10 for the VAI Epigenomics Workshop. This 3-day, hands-on, problem-based experience will immerse PhD students in the latest epigenomics research and techniques. Please share with anyone who might be interested! vai.org/event/vai-epigenomic…
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Holes in the patio umbrella on the terrace ⁦@VAInstitute⁩ produced hundreds of tiny eclipse shadows for us to enjoy. ⁦@BurtonNick⁩ was right place right time to catch some on his shirt too!
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A pair of medications that make malignant cells act as if they have a virus could hold promise for treating #colorectalcancer & other solid tumors, according to a new preclinical study by scientists @RothbartLab. #ColorectalCancerAwarenessMonth vai.org/rothbart-crc-study
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Scott Rothbart retweeted
ACS Research@ACS_Research28 Mar 2024
"The unmet potential of DNA methyltransferase inhibition therapy in patients with solid tumors underscores the importance of our findings." Congrats to @AmericanCancer grantee @RothbartLab for this this exciting study as we come to the end of #ColorectalCancerAwarenessMonth!
Scott Rothbart@RothbartLab28 Mar 2024
New paper from the lab reveals a link between epigenetic therapy-induced viral mimicry and NFAT:AP1 signaling. Rationale for combining DNMT and EZH2 inhibitors in colon cancer. Thankful to ⁦@theNCI⁩ and ⁦@ACS_Research⁩ for supporting our work! science.org/doi/10.1126/scia…

Select EZH2 inhibitors enhance viral mimicry effects of DNMT inhibition through a mechanism...

Select EZH2 inhibitors enhance DNMT inhibitor–induced viral mimicry in colon cancer cells through NFAT:AP-1 signaling.

science.org
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New paper from the lab reveals a link between epigenetic therapy-induced viral mimicry and NFAT:AP1 signaling. Rationale for combining DNMT and EZH2 inhibitors in colon cancer. Thankful to ⁦@theNCI⁩ and ⁦@ACS_Research⁩ for supporting our work! science.org/doi/10.1126/scia…

Select EZH2 inhibitors enhance viral mimicry effects of DNMT inhibition through a mechanism...

Select EZH2 inhibitors enhance DNMT inhibitor–induced viral mimicry in colon cancer cells through NFAT:AP-1 signaling.

science.org
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