@LinusButt

physician scientist, interested in glomerular diseases | @UKKoeln | currently University of Cambridge/Sanger @ClatworthyLab

 Köln, Deutschland
Joined February 2012
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  • Following388
  • Followers829
3Media
Projekt-Manager für ein großes klinisches Studienprojekt (im Bereich Nephrologie) gesucht, multizentrische IIT (AMG). Lust in einem engagierten Studienteam mitzuarbeiten? Eine internationale Studie zu koordinieren? Dann sehr gerne direkt bei mir melden.
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One of the most pressing questions in the era of caplacizumab is if iTTP can be managed without plasma exchange! Check out our paper addressing this question: Management of Immune Thrombotic Thrombocytopenic Purpura without Therapeutic Plasma Exchange ashpublications.org/blood/ar…

Management of immune thrombotic thrombocytopenic purpura without therapeutic plasma exchange

Key PointCaplacizumab with immunosuppression, but without additional TPE, is an effective and safe treatment strategy for acute iTTP.

ashpublications.org
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Linus Butt retweeted
Kasia Bozek@bozeklab1 Mar 2024
We perform a fully unsupervised analysis of the filtration barrier in kidney and show that it allows to group images in a way that reflects their morphometry: frontiersin.org/articles/10.… Great collaboration with the NephroLab @unnersjo @LinusButt !

Frontiers | Self-supervised representation learning of filtration barrier in kidney

While the advance of deep learning has allowed to automate many tasks in bioimage analysis, quantifying key visual features of biological objects in an image...

frontiersin.org
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Linus Butt retweeted
Kasia Bozek@bozeklab9 Jan 2024
We have a freshly funded consortium in eye medicine in Cologne with plenty of challenging image analysis tasks ahead. We're looking for a postdoc, please spread/apply! euraxess.ec.europa.eu/jobs/1…
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Advanced optical imaging reveals preferred spatial orientation of #podocyte processes along the axis of glomerular capillaries. doi.org/10.1016/j.kint.2023.… #glomerulus #ultrafiltration
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Deep learning–based segmentation and quantification of #podocyte foot process morphology suggests differential patterns of foot process effacement across #kidney pathologies doi.org/10.1016/j.kint.2023.… #ArtificialIntelligence #pathology @KTHuniversity @UniCologne
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Our study on deep learning-based segmentation and multi-parameter morphology analysis of foot processes is online! Thanks for a great collaboration @LinusButt @bozeklab @HoehneMartin @BernhardScherm1 kidney-international.org/art…
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New preprint out. Using 3D high-resolution imaging, we found that the orientation of podocyte processes is likely governed by the mechanical forces acting on them. Thanks to all co-authors! @amer_rc @LinusButt @HoehneMartin @BernhardScherm1 biorxiv.org/content/10.1101/…

Mechanical forces at the kidney filtration barrier govern spatial orientation of podocyte processes...

Mammalian kidneys filter enormous volumes of water and small solutes, a filtration driven by the very high hydrostatic pressure in glomerular capillaries. Interdigitating cellular processes of...

biorxiv.org
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Caloric restriction protects from #kidney injury in rodents. But translation to humans requires unravelling the molecular mechanisms. A spotlight on NAD de novo biosynthesis and acetylation of metabolic enzymes. @UniCologne @CECAD_ @UKKoeln see 🧵below journals.lww.com/jasn/Abstra…
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Our meeting report on the 13th International Podocyte Conference 2021 is out. Thanks to the fabulous Rachel Lennon @RLWczyk and her team and all other authors. @syb_k @fab_braun @LinusButt @F_Lausecker @MarylineFresqu1 pubmed.ncbi.nlm.nih.gov/3596…

Integrating basic science with translational research: the 13th International Podocyte Conference...

The 13th International Podocyte Conference was held in Manchester, UK, and online from July 28 to 30, 2021. Originally planned for 2020, this biannual meeting was postponed by a year because of the...

pubmed.ncbi.nlm.nih.gov
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Finally heading for our nephrolab retreat! 🏝🏝🏝
Team Nephrolab Cologne

ALT Team Nephrolab Cologne

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Linus Butt retweeted
@CKD_ce
@ckd_ce28 Apr 2022
19) Thank you for coming back! You are learning from @hjanders_hans all about #CKD + #T2D while you earn 🆓CE/#CME! Hello to @kdjhaveri @KuppeChristoph @Tiff_Caza @AstridWeins @suz_allison @LinusButt @Renalpathsoc @JeanHouMD @ChristophWanne4 @mvaduganathan @KidneyPath
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Which longevity-associated dietary intervention protects best from ischemia-reperfusion injury? Check out Felix Koehler's recent work bit.ly/35l38Sq to find the answer and some insights into a convergent metabolic response. #diet #kidney #longevity
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Linus Butt retweeted
JASN_News@JASN_News6 Dec 2021
Mice carrying a common mutation in the gene encoding podicin show signs of podocyte injury as they age and after injection with a nephrotoxin—suggesting that the mutation confers a genetic predisposition to glomerular disease bit.ly/j202006085 @HoehneMartin
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📣 🆕 𝗜𝗦𝗡 𝗩𝗜𝗗𝗘𝗢 𝗔𝗕𝗦𝗧𝗥𝗔𝗖𝗧 𝗦𝗘𝗥𝗜𝗘𝗦: A mathematical estimation of the physical forces driving podocyte detachment. 2021 from @kidney_Int kidney-international.org/art… @LinusButt @unnersjo @HoehneMartin @BernhardScherm1
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Great to see our recent review on the current knowledge of #RNA-binding proteins in #kidney disease and potential therapeutic implications published online by @NatRevNeph. Wonderful work, @SisaLeufert and the great team @CECAD_ @UniCologne @UKKoeln nature.com/articles/s41581-0…

RNA-binding proteins and their role in kidney disease

Nature Reviews Nephrology - RNA-binding proteins are involved in every stage of the RNA life cycle and have a major impact on cellular biology. Here, the authors discuss current knowledge of...

nature.com
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New preprint for all you paraffin embedding-lovers out there, with @amer_rc @LinusButt @HoehneMartin @BernhardScherm1 and others.
bioRxiv@biorxivpreprint3 Sep 2021
Three-dimensional Super-resolved Imaging of Paraffin-embedded Kidney Samples biorxiv.org/cgi/content/shor… #bioRxiv
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A fantastic start to #podocyte2021 - the pre-meeting organised the amazing early career team ⁦@F_Lausecker⁩ ⁦@RW_Naylor⁩ ⁦@MarylineFresqu1⁩ ⁦@PinyuanTian⁩ ⁦@syb_k⁩ & ⁦@LinusButt⁩ - congrats! You have set the bar high!! ⁦@podocyte2021⁩
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The glomerular filtration barrier: a structural target for novel kidney therapies go.nature.com/36Eh6fH - find out about the potential for a new generation of drugs for kidney diseases in this new review by @ilse_daehn @ISMMSKidney @DOMSinaiNYC and Jeremy Duffield @DuffieldLab
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Check out AMAP, our fully automated algorithm for segmentation and quantification of foot process morphology. Great collaborative effort with ⁦@unnersjo⁩ ⁦@bozeklab⁩ ⁦@HoehneMartin⁩ ⁦@BernhardScherm1⁩ and more biorxiv.org/content/10.1101/…

Deep learning-based segmentation and quantification of podocyte foot process morphology

The kidneys constantly filter enormous amounts of fluid, with almost complete retention of albumin and other macromolecules in the plasma. Diseases of podocytes at the kidney filtration barrier...

biorxiv.org
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