@LeeRubinLab

Neuroscientist studying brain aging and disease leading a lab filled with incredible scientists at the @hscrb department. •Asian food enthusiast.

 Cambridge, MA
hscrb.harvard.edu/res-fl-rubin
Joined March 2019
  • Tweets51
  • Following96
  • Followers636
4Media
What are the latest strategies to reverse the effects of aging on brain function? What drives tissue regeneration in the skin and eye, and how can we harness it to treat age-related disease? Join #NYSCF2025 to find out! Advance registration closes 3/14: conference.nyscf.org/registr…
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Lee Rubin retweeted
HSCRB@HSCRB14 Jun 2023
Check out recent research from @LeeRubinLab, featured on @NatureComms Editors' Highlights page. nature.com/collections/mjkks…

From brain to behaviour

On this page, we highlight some of the most exciting neuroscience papers that advance our understanding of the brain, covering neurodegeneration, neurological ...

nature.com
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We are excited to welcome our 2023 NYSCF - Druckenmiller Fellows: @AnuHemalatha (@YaleGenetics), Kentaro Iwasawa (@CincyChildrens), Brian J. Joseph (@Columbia), Kaylee Wells (@Harvard), and Jiajie Xu (@MassGeneralNews)! nyscf.org/programs/extramura…
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Lee Rubin retweeted
HSCRB@HSCRB22 Dec 2022
New research from @LeeRubinLab in @stemcellreports opens up new avenues for studying inflammatory responses and their regulation in human #astrocytes and serves as a platform to identify therapeutic drugs for #Schizophrenia. cell.com/stem-cell-reports/f…
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Excited to share this manuscript-the first from our bi-coastal collaboration between the Ritz/Khurana/Rubin labs using iPSC-derived dopamine neurons to learn more about the role of pesticides in Parkinson's Disease biorxiv.org/content/10.1101/… @beate_ritz @khurana_lab @LeeRubinLab

Coupling comprehensive pesticide-wide association study to iPSC dopaminergic screening identifies...

Parkinson’s disease (PD) is a complex, multi-factorial neurodegenerative disease, known to involve genetic, aging-related components, but also to be highly sensitive to environmental factors. In...

biorxiv.org
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Excited to share our preprint showing that parabiosis regulates aging hallmarks by shifting aging-induced changes of the transcriptome in multiple brain cell types. Great teamwork between @LeeRubinlab @jzlevin AvivRegev AmyWagers | @HSCRB @BroadInstitute | biorxiv.org/content/10.1101/…

Heterochronic parabiosis reprograms the mouse brain transcriptome by shifting aging signatures in...

Aging is a complex process involving transcriptomic changes associated with deterioration across multiple tissues and organs, including the brain. Recent studies using heterochronic parabiosis have...

biorxiv.org
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Researchers in a new Science study used electron cryo–electron microscopy to determine the structures of Aβ42 filaments from human brain. These structures aid in understanding the development of amyloid diseases. Learn more: fcld.ly/azf0679; fcld.ly/72wtzy7
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In Serine and Jon's work (science.org/doi/10.1126/scie…) we competed normal and mutant stem cells in a zebrafish while marking the clones in different colors. We modeled mutations causing clonal hematopoiesis of aging- found a pathway to restore clonal balance. answers.childrenshospital.or…

Resistance to inflammation underlies enhanced fitness in clonal hematopoiesis

In zebrafish blood stem cells, clonal fitness of mutant clones is driven by enhanced resistance to inflammatory signals.

science.org
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Today we report in @biorxivpreprint twin prime editing, a variant of prime editing that enables in human cells targeted large DNA deletion and replacement, as well as gene-sized integration and inversion when combined with site-specific recombinases. 1/9 biorxiv.org/content/10.1101/…
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How do stem cells maintain their regenerative potential throughout life? Can this potential be preserved to prevent aging? What are the most recent innovations in biomaterials for cell therapy? Find out next week at #NYSCF2021! Register here: bit.ly/2ZZ4Rdz
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Transplanting gut microbiota from young to old mice can counteract specific aging-associated changes in the brain, according to a study in @NatureAging. go.nature.com/3yN05wp
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Congrats to @LeeRubinLab & colleagues for their new #SkeletalMuscle paper: Pro-myogenic small molecules revealed by a chemical screen on primary muscle stem cells. tinyurl.com/yxlcuoju
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NEW PAPER in @stemcellreports by @AhfeldtTim & @Harvard’s Lee L. Rubin on "Pathogenic Pathways in Early-Onset Autosomal Recessive #ParkinsonsDisease Discovered Using Isogenic Human Dopaminergic #Neurons". CONGRATULATIONS! 🎉🍾cell.com/stem-cell-reports/f…
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Lee Rubin retweeted
HSCRB@HSCRB19 Jul 2019
By analyzing health insurance records, @LeeRubinLab identified connections between spinal muscular atrophy and problems in other parts of the body. These whole-body symptoms could serve as an early warning system: hscrb.harvard.edu/news/spina…

Spinal Muscular Atrophy’s early warning system | HSCRB

Harvard study identifies whole-body symptoms of rare nerve disease

hscrb.harvard.edu
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Lee L. Rubin of @Harvard now speaking at #ITMAT about research on improving brain function and what can be done to treat people who already have cognitive loss or other types of impairment associated with neural degeneration @LeeRubinLab
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Excited that our paper is out @NatureNeuro. We present a single-cell atlas of the aging mouse brain that hopefully will help towards understanding #aging. Credits to @LeeRubinLab @HSCRB | JoshuaLevin, AvivRegev @BroadInstitute | @GaryBader1 @DonnellyCentre nature.com/articles/s41593-0…
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