@LainaHall

@UCB_biophysics graduate student with @bronwynalucas

Joined July 2020
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  • Followers140
8Media
Finally got around to crafting some sds page earrings (complete with my favorite type III crispr complex)!
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This month's faculty focus interview features Bronwyn Lucas! On running a lab: "It’s about equipping the people in my lab to tackle challenges & mentoring them as they develop their own approaches." Read more on our website: bit.ly/QB3_Bronwyn
The Lucas lab gathered outside on a balcony overlooking Berkeley.

ALT The Lucas lab gathered outside on a balcony overlooking Berkeley.

Individual ribosomes and ribosome precursors visualized inside a yeast cell.

ALT Individual ribosomes and ribosome precursors visualized inside a yeast cell.

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The Cryo-EM: the next 50 years Symposium held yesterday at @UCBerkeley was a smashing success!!
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We're Hiring! Assistant Professor of Biochemistry, Biophysics, and Structural Biology in MCB. Learn more and apply online: aprecruit.berkeley.edu/JPF04…
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Congrats to MCB's Bronwyn Lucas @bronwynalucas and Ziyang Zhang @bignerdzzy on being among the 2024 #NIHHighRisk New Innovator Awardees! @NIH_CommonFund 👏🎉commonfund.nih.gov/newinnova…
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1/8 ❄️🔬Excited to share our latest work published in @NatureComms! Led by @kaitlyn_m_abe and in colab with @GrantCryoEMLab, we've discovered a simple, cost-effective way to mitigate sample damage at the air-water interface during grid preparation. #CryoEM rdcu.be/dSWfn
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I can’t think of cooler work to fund, but am a bit biased. Congratulations!!
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Check out the latest story from the Sternberg group: phages coopted transposon-encoded nucleases (TnpB) and repurposed them for regulation of host genes! nature.com/articles/s41586-0… Thrilled to see this work in print, & a huge thanks to my amazing co-authors!!

TnpB homologues exapted from transposons are RNA-guided transcription factors

Nature - RNA-guided transcription factors arose repeatedly via the domestication of transposon-encoded tnpB genes, representing a parallel evolutionary path to CRISPR-Cas adaptive immunity.

nature.com
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Congrats to MCB's David Savage @SavageCatsOnly on his promotion to Professor of Biochemistry, Biophysics and Structural Biology! 👏🥂 mcb.berkeley.edu/news-and-ev…
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Recently, @KimiHerath, Matthew, and I were lucky enough to become the Lucas labs (@bronwynalucas) first graduate students. We‘ll be spending the summer finding proteins inside cells, learning and raiding the stellar snack cupboard at the @cziscience imaging institute
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Cellular repair of DNA breaks enables editing of the human genome. Do human cells repair RNA breaks, and can we use it to edit transcriptomes? Our work with @ANemudraia and @WiedenheftLab is now online in @ScienceMagazine! #ScienceResearch science.org/doi/10.1126/scie…

Repair of CRISPR-guided RNA breaks enables site-specific RNA excision in human cells

Genome editing with CRISPR RNA-guided endonucleases generates DNA breaks that are resolved by cellular DNA repair machinery. However, analogous methods to manipulate RNA remain unavailable. We show...

science.org
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What limits rubisco function? Is it the chemical mechanism? Evolution? In an updated pre-print @prywes et. al explore this question by assaying >99% of single amino acid mutants in Form II rubisco (1/7)
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New preprint! @ben_a_adler and I @doudna_lab, in collaboration with @Emy_nim and @JoePogliano, unveil a mechanism for Hachiman immunity. The punchline - Hachiman is a genome integrity sensor. @UCB_Chemistry @igisci @HHMINEWS biorxiv.org/content/10.1101/… 🧵 1/14

Hachiman is a genome integrity sensor

Hachiman is a broad-spectrum antiphage defense system of unknown function. We show here that Hachiman comprises a heterodimeric nuclease-helicase complex, HamAB. HamA, previously a protein of unknown...

biorxiv.org
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The Santiago-Frangos lab is open and ready to do some exciting research on CRISPR biology and CRISPR applications! Ecstatic to be on UPenn's campus amongst such a supportive group of excellent scientists!🤓
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Our team at #CZImagingInstitute is excited to share the #CryoET Data Portal beta release. With over 13,000 tomograms, it’s the start of what we hope will be a large, open-access portal of high-quality, standardized & annotated cryo-ET data. bit.ly/3T9sZ6D
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Please join me in congratulating @dominick_faith on advancing to PhD candidacy! Congrats Dom! Special thanks to @WiedenheftLab for joining us from Montana State this morning
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Embarrassing how giddy I was to see that my favorite podcast highlighted my paper! Go to minute 36 for a Bozeman shoutout :)
MicrobeTV@profvrr17 Sep 2023
TWiV 1045: Less Lassa, CRISPR RNA viruses 〰️ TWiV reviews a Lassa virus mRNA vaccine that confers protection against disease without inducing neutralizing antibodies, and a CRISPR-based method for engineering the genome of RNA viruses. 📺 bit.ly/3PEvpYO
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📢I'm hiring! Postdocs, PhDs, and Research Techs at Dept. of @PennBiology at @Penn! We'll use bioinformatics 🖥️, biochem 🧪, and cryo-EM ❄️🔬, to study how CRISPR systems work & applications. Work on cool science with a supportive mentor! web.sas.upenn.edu/sanfrango-… RTs appreciated!
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Did you know there’s a tiny town in Montana with two Krios scopes? Beyond a large Krios per capita ratio, the people are really what makes this place special! Grateful for my time learning EM at Rocky Mountain Labs, and excited to start grad school at @UCBerkeley this fall!
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Over the last year, I fell down a rabbit hole that ended up tumbling me through one the biggest paradigm shifts I've experienced in my four decades on this planet. Today, I share it with you. I hope you, squawk, enjoy. radiolab.org/podcast/seagull…

The Seagulls

How a study about seagulls from the 1970s rocked our understanding of what’s natural in animals... and in us.

radiolab.org
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Cannot say enough good things about Andrew as a mentor, scientist and person. So exciting and highly recommended this lab to incoming students!
Andrew Santiago-Frangos, PhD@SantiagoFrangos21 May 2023
Delighted to share I'll be joining the wonderful folks at the Department of @PennBiology at @Penn as an Assistant Professor in Jan 2024. The Santiago-Frangos lab will study how bacteria make DNA memories of phage infections, and how @CRISPR systems signal an anti-phage response.
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