@LabScribbles

Principal Investigator Huntington's Disease Research @TheSGCOnline, Assistant Prof Dept Pharmacology & Toxicology @UofT, Editor-in-chief @HDBuzzFeed, she/her

 Toronto, Ontario
labscribbles.com
Joined December 2015
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  • Following612
  • Followers901
77Media
I am thrilled to share that I have been awarded the Nancy Wexler Young Investigator Prize from the Hereditary Disease Foundation. A big thanks to the HDF for their continued support of my team's work hdfoundation.org/nancy-s-wex…
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We couldn't be prouder of @LabScribbles who joined @UofTPharmacy as an Assistant Professor! Please join us in congratulating Dr. Harding on this remarkable achievement! 📲 thesgc.org/news/dr-rachel-ha…
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We're pleased to welcome Assistant Prof. Rachel Harding (@LabScribbles) to the Department of Pharmaceutical Sciences at UofTPharmacy! Prof. Harding's research aims to unravel the complexities of Huntington’s disease & forge new paths for therapeutics 📖⬇️ pharmacy.utoronto.ca/news-an…

U of T Pharmacy welcomes leading structural biologist focused on advancing Huntington’s Disease...

Professor Harding aims to unravel the complexities of Huntington’s disease to forge new paths for therapeutic development and intervention.

pharmacy.utoronto.ca
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Huntingtin is an RNA binding protein and participates in NEAT1-mediated paraspeckles pubmed.ncbi.nlm.nih.gov/3902… Awesome study by Manisha Yadav, @LabScribbles , @pouladi , @hansenhe7 and Pearson Labs

Huntingtin is an RNA binding protein and participates in NEAT1-mediated paraspeckles - PubMed

Huntingtin protein, mutated in Huntington's disease, is implicated in nucleic acid-mediated processes, yet the evidence for direct huntingtin-nucleic acid interaction is limited. Here, we show...

pubmed.ncbi.nlm.nih.gov
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Replying to @LabScribbles
@LabScribbles was recently honored with the @hdfcures Nancy S. Wexler Young Investigator Prize. The foundation has also provided funding to support Dr. Harding's research on the interaction between the Huntingtin protein and HAP40. thesgc.org/news/dr-rachel-ha…
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Rachel Harding retweeted
aled edwards@aledmedwards20 Jun 2024
A win for @thesgconline’s Rachel and her scientific and #openscience leadership!
HDF@hdfcures19 Jun 2024
HDF is honored to present our 2024 Nancy S. Wexler Young Investigator Prize to Rachel Harding who is committed to collaboration to find a treatment for #Huntingtonsdisease. Learn more: tinyurl.com/NSWPrize2024 #research #cures #cureHD @HDYOFeed @AmericanBrainCo @HDBuzzFeed @HDSA
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We are proud of our very own @LabScribbles! Rachel has been working on #HuntingtonsDisease at SGC-Toronto with a strong ethos of #OpenScience and collaboration. Congratulations, Rachel, on this well-deserved recognition!
HDF@hdfcures19 Jun 2024
HDF is honored to present our 2024 Nancy S. Wexler Young Investigator Prize to Rachel Harding who is committed to collaboration to find a treatment for #Huntingtonsdisease. Learn more: tinyurl.com/NSWPrize2024 #research #cures #cureHD @HDYOFeed @AmericanBrainCo @HDBuzzFeed @HDSA
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Rachel Harding retweeted
Matthieu Schapira@mattschap6 Jun 2024
Now peer-reviewed: rdcu.be/dJ7IY ... and just funded by a 5-year #CIHR grant to see with @fgentile9,@LabScribbles,@thesgconline, @chem4biology and a growing number of chemistry labs what this expanding non-commercial chemistry space can do for hit finding.
Matthieu Schapira@mattschap12 Dec 2023
Happy to explore with Canadian chemists a mechanism, pioneered by @chem4biology, to open academic chemistry to ultra-large virtual screening. Useful for challenging targets where the commercial chemistry space is not sufficient: bit.ly/3RikUtY @thesgconline
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Today is the International Day of #HuntingtonsDiseaseAwareness. Read more about the recent visit of the @HuntingtonSC to the SGC. Families saw firsthand the progress of @LabScribbles' group in #HDResearch. ▶️thesgc.org/node/1649788
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How benchmarking challenges and data in the public domain will guide development in AI-based methods and breakthroughs in #drugdesign on a scale analogous to that seen for protein fold prediction? @mattschap @LabScribbles @CherylArrowsmi1 @HalabelianLab nature.com/articles/s41589-0…
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Through #OpenScience collaborations, we make our research outputs available to the scientific community with no strings attached. If you haven't already, check @LabScribbles and @CherylArrowsmi1 last preprint on #Huntingtonsdisease biorxiv.org/content/10.1101/…

Huntingtin is an RNA-binding protein and participates in NEAT1-mediated paraspeckles

Huntingtin protein, mutated in Huntington disease, is implicated in nucleic acid- mediated processes, yet evidence for direct huntingtin-nucleic acid interaction is limited. Here we show wildtype and...

biorxiv.org
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In-depth perspective on the first CACHE challenge in @NatRevDrugDisc nature.com/articles/d41573-0… #compchem @thesgconline @consciencemeds
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A new study demonstrates for the first time the ability of Huntingtin protein to directly bind to RNA species. Read our preprint and learn more about the role of a specific RNA, called NEAT1, in connecting with Huntingtin within cells. 📰 biorxiv.org/content/10.1101/…

Huntingtin is an RNA-binding protein and participates in NEAT1-mediated paraspeckles

Huntingtin protein, mutated in Huntington disease, is implicated in nucleic acid- mediated processes, yet evidence for direct huntingtin-nucleic acid interaction is limited. Here we show wildtype and...

biorxiv.org
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CACHE#1 results are in: bit.ly/48zjBhI. No prior ligand for the target. 1955 compounds predicted by 23 experts. 7 convincingly confirmed experimentally. This is the state-of-the-art. Exploration of modern AI techniques in 6 of the 7 top performing methods. #compchem
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"A protein implicated in a disease, remains a lock without a key unless a molecule can be found to bind to it and deter its harmful effects". Glad to see @globeandmail featuring CACHE Challenges in their piece on AI-guided #drugdiscovery. @consciencemeds theglobeandmail.com/canada/a…

In the quest for new medicines, developers seek to make AI their divining rod

Developing and testing a drug candidate can take years of effort and billions of dollars of investment. Any shortcut that AI can offer could be a game changer

theglobeandmail.com
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Replying to @mattschap
@mattschap, @LabScribbles and Derek Wilson identified a chemical handle that binds to USP3 without affecting its normal function. This compound provides a foundation for future USP3-recruiting DUBTACs to rescue targets from proteasomal degradation. pubs.acs.org/doi/10.1021/acs…

Small Molecule Screen Identifies Non-catalytic USP3 Chemical Handle

Abstract. Zinc-finger ubiquitin-binding domains (ZnF-UBDs) are noncatalytic domains mostly found in deubiquitylases (DUBs) such as USP3. They represent an

pubs.acs.org
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Announcing the 5th CACHE challenge. Predict novel antagonists for MCHR1, a GPCR with no structure in the PDB but hundreds of known ligands... Compounds will be tested in Bryan Roth @zenbrainest lab at UNC and results published. Apply by Feb 14th. bit.ly/484U7Zi #compchem
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Rachel Harding retweeted
HDBuzz@HDBuzzFeed20 Dec 2023
Steady progress from uniQure - promising data to end the year - ift.tt/aqYxPHZ
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Rachel Harding retweeted
Nikola Stikov@Stikov20 Dec 2023
A lay introduction to the @NeuroLibre publishing initiative conp.ca/about-neurolibre/ Big thank you to Patrick Bermudez, Rachel Harding (@LabScribbles), Estrid Jakobsen (@Estrid_J) and the CONP Communication Committee on putting this together!

What is NeuroLibre? - the Canadian Open Neuroscience Platform

NeuroLibre is the CONP's platform for reproducible publishing. Each paper is published with its code, data and computing environment, archived and re-executable, so that readers can examine and reuse...

conp.ca
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A chemical handle that binds to but does not inhibit USP3... In principle it could serve as a starting point for future USP3-recruiting DUBTACs to rescue targets from proteasomal degradation. @thesgconline Fun collab. with @LabScribbles and Derek Wilson! bit.ly/41sxlbo
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