Drug Discovery | Structural Biology | WDR protein family | PI at the SGC-University of Toronto | all opinions are my own.
SGC-Toronto
Joined March 2023
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Our recent crystal structure of TREX1 in complex with a small molecule inhibitor is now available online.
#drugdiscovery #cachechallenge
rcsb.org/structure/8VL7
Levon retweeted
New Blog Post 📢
Learn how @HalabelianLab utilizes AI-driven hit-finding technologies to discover small molecules targeting the WDR protein family and help elucidate the dark proteome.
#OpenScience #drugdiscovery #AI
thesgc.org/node/1649725
Levon retweeted
A comprehensive study by @HalabelianLab reveals the interaction of a small molecule which binds to Cbl-b and acts as an intramolecular glue locking the protein in an inactive state.
Read more: nature.com/articles/s42003-0…
Levon retweeted
Structural and biophysical characterization of a small molecule binding to Cbl-b E3 ligase reveals an intermolecular glue mechanism locking the protein in an inactive state: nature.com/articles/s42003-0…
@HalabelianLab @thesgconline
Levon retweeted
WDR proteins are a large, druggable, and underexplored target class with strong disease associations.
@HalabelianLab just released several WDR structures in complex with inhibitors, which were identified using DEL-ML, in collaboration with @Relay_Tx, @XChemInc and @Google.
Exciting to share that our DCAF1 manuscript is now available online. It was great collaborating with the OICR team to advance this molecule into a nanomolar affinity DCAF1 ligand.
A cool approach utilizing the DEL technology and #MachineLearning models for the discovery and cellular target engagement of the first nanomolar DCAF1 ligand. This is a great example of collaborative science between @OICR_news, @Relay_Tx and the SGC.
pubs.acs.org/doi/10.1021/acs…
Our recent structure of CBL-B in complex with N-Aryl isoindolin-1-one inhibitor is now released. rcsb.org/3d-view/8GCY/1
#E3ligase
