@LabParp

Research in biochemistry and structural biology of PARP enzymes and bacterial toxins

Joined January 2021
  • Tweets42
  • Following63
  • Followers102
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Excited to have been awarded @lunduniversity infrastructure support to establish a mini structural bioinformatics facility, LU-Fold. Watch this space!
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PARP lab Lund retweeted
Eugene Kim@eugene_kim__14 May 2022
Excited to share new preprint from my lab @MPIbp in collaboration with #CamillaBjörkegren’s lab at Karolinska Institute! biorxiv.org/cgi/content/shor… (0/n) In this work, we reveal that Smc5/6 complex is a DNA loop extruding motor.
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hopfnerlab@hopfnerlab18 Jan 2022
Another step towards uncovering the secrets of the Schlafen protein family. Check out how we tackled SLFN5 by crystallization and #CryoEM : academic.oup.com/nar/advance… – at Munich, Germany
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Forskningsingenjör i Cryo-EM at @lunduniversity @medfak_LU lu.varbi.com/en/what:job/job…

Research engineer to the cryo-EM research community

Cryo-EM at Lund U niversit y A growing group of researchers at Lund University are using cryo-electron microscopy, especially in its "single-particle" form, to investigate their structural biological

lu.varbi.com
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2 year Cryo-EM engineer job at Lund University. Don't be put off that the ad is in Swedish, as the only formal language requirement is communication skills in English
Vasili Hauryliuk@hauryliuk18 Jan 2022
Forskningsingenjör i Cryo-EM at @lunduniversity @medfak_LU lu.varbi.com/en/what:job/job…

Research engineer to the cryo-EM research community

Cryo-EM at Lund U niversit y A growing group of researchers at Lund University are using cryo-electron microscopy, especially in its "single-particle" form, to investigate their structural biological

lu.varbi.com
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PARP lab Lund retweeted
John Pascal Lab@LabPascal29 Nov 2021
Happy to share our first Cryo-EM structure! Cryo-EM structures and biochemical insights into heterotrimeric PCNA regulation of DNA ligase cell.com/structure/fulltext/…

Cryo-EM structures and biochemical insights into heterotrimeric PCNA regulation of DNA ligase

Sverzhinsky et al. use cryoelectron microscopy to investigate the complex formed by DNA ligase and the sliding clamp PCNA as they bind a nicked DNA molecule. They obtain snapshots of DNA ligation...

cell.com
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Sorry we forgot to add the time: it will be 5pm Paris, 11am Boston, 11pm Beijing like for the first series.🧐 In case, the poster updated with the time is added to this post.👍
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PARP lab Lund retweeted
Eric Brown
@ericmichbrown16 Aug 2021
Super excited to be able to share this study on gut microbiome ADP-ribosyltransferases and their role as phage-encoded fitness factors in the gut. Been a great collaboration with @HASCiencia and @Novartis along with @broadinstitute @MGH_RI & @emilytemple_ cell.com/cell-host-microbe/f…

Gut microbiome ADP-ribosyltransferases are widespread phage-encoded fitness factors

Brown et al. report prevalent ADP-ribosyltransferases in gut microbiome commensals that are associated with bacteriophage elements and secreted as active enzymes. An abundant ADP-ribosyltransferase...

cell.com
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PARP lab Lund retweeted
Da-Neng Wang@danengw28 Jul 2021
Hardcopies of the #CryoEM book by Bob Glaeser, @NogalesLab & @WahChiu1 I ordered months ago have finally arrived. Thanks to the editors and all the chapter authors, we now have an updated textbook for graduate level teaching.
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Serine ADP-ribosylation marks nucleosomes for ALC1-dependent chromatin remodeling dlvr.it/S3Hlmz
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The Lehtiö Lab@LabLehtio9 Jun 2021
Our story about the PARP2-DNA complex is published now on Nature Communications. There is a supplementary video also made by Albert. #fbmm #biocenteroulu @UniOulu @instructhub @CentreFi nature.com/articles/s41467-0…

Activation of PARP2/ARTD2 by DNA damage induces conformational changes relieving enzyme autoinhib...

Nature Communications - Poly(ADP-ribose) polymerase 2 (PARP2) is activated by 5′-phosphorylated DNA breaks but the molecular mechanism is not fully understood. Here, the authors report a...

nature.com
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PARP lab Lund retweeted
The Lehtiö Lab@LabLehtio19 May 2021
X-rays, neutrons and electrons. Crystallography. Course. Virtual. Summer 2021. Excellent teachers! #instruct #UniOulu #fbmm #biocenteroulu @Diamond_MX #FINStruct instruct-eric.org/events/ins…

Instruct-ERIC course on macromolecular X-ray, electron and neutron crystallography

Date: 29-Jun-2021 to 06-Jul-2021 The remote practical course covers principles, differences and applications of macromolecular crystallography using X-rays, neutrons and electrons. The course is...

instruct-eric.org
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PARP lab Lund retweeted
WebFlaGs@webflags14 May 2021
We're back online! Hope you didn't miss us too much! webflags.se
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Tagging of cellular complexes with #CRISPR allows purification for #cryoEM. With @YueLabOX and @v_paavilainen our structures of endogenous TRiC chaperonin reveal interactions with its substrates actin and tubulin biorxiv.org/content/10.1101/… @OxfordStrubi @BIOTECH_UH @HiLIFE_helsinki
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PARP lab Lund retweeted
Saei Lab
@AmirAta827 Feb 2021
Our new work is out and it is called SIESTA (because what else?). It can identify enzyme substrates by thermal analysis. We hope that SIESTA will have huge impacts in drug discovery! My first corresponding author yet. Great collaboration @RZLabKI @LabParp dlvr.it/RtYQ2Y
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PARP lab Lund retweeted
RZLab@RZLabKI9 Mar 2021
Our SIESTA paper now featured in the Structural Biology, Biochemistry and Biophysics collection of Nature Communications! nature.com/collections/hhfig…
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Out today! our study of PRMT5 inhibitors in GBM disrupt splicing, cell cycle and stemness. Awesome collaboration with @BrainSurgn1989, @thesgconline, @katlinbm, @bhaibeka @MatLupien, and many others @SU2C_Canada Cancer Stem Cell Dream Team. rdcu.be/cfaDG
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