@LabMotori

We study mitochondria, neurometabolism and neurodegeneration. Our lab is located at the University of Cologne, Germany.

 Cologne, Germany
Joined February 2022
  • Tweets106
  • Following217
  • Followers546
3Media
Motori Lab retweeted
CECAD Cologne@CECAD_27 Sep 2024
🔬👩‍🔬🧑‍🔬👨‍🔬 A wonderful day of networking and scientific exchange for the Research #GroupLeaders Retreat 2024 at @CECAD_ today! #AgingResearch
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A big day for the Cologne mitochondrial community! The #CRC1218 is funded by the DFG for another four years! This collaborative grant will foster exciting discoveries on how #mitochondria regulate cell function. Thank you to all colleagues, postdocs, and PhD students involved.
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How do axons maintain functional #mitochondria? Happy to share our last #CLUH story. #ScienceAdvancesResearch science.org/doi/10.1126/scia…

CLUH maintains functional mitochondria and translation in motoneuronal axons and prevents periphe...

CLUH regulates mitochondrial function in peripheral motor axons, thus promoting growth and preventing degeneration.

science.org
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#ERLIN1 and ERLIN2 are involved in #HSP. Check out our paper about their role to define nanodomains at the #ER. doi.org/10.26508/lsa.2024026…

ERLIN1/2 scaffolds bridge TMUB1 and RNF170 and restrict cholesterol esterification to regulate the...

Complexes of ERLIN1 and ERLIN2 (ER lipid raft–associated 1 and 2) form large ring-like cup-shaped structures on the endoplasmic reticulum (ER) membrane and serve as platforms to bind cholesterol and...

life-science-alliance.org
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We are very happy to share our work Weak neuronal glycolysis sustains cognition and organismal fitness which is out today in open access at @NatMetabolism !! A great effort led by #DaniJimenezBlasco and an excellent group of collaborators !! nature.com/articles/s42255-0… 🧵 1/5👇

Weak neuronal glycolysis sustains cognition and organismal fitness

Nature Metabolism - Jiménez-Blasco et al. show that neurons exhibit moderately low glycolytic rates despite their activity being mainly supported by glucose to preserve redox balance.

nature.com
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Excited to share our highlight on this incredible work by Zorzano and Scorrano's groups! Check it out now! 📚
Bergami Lab@bergami_lab1 Jan 2024
Our take (@bergami_lab and @LabMotori) on the recent findings from Zorzano's lab and @LabScorrano on MFN2 splice variants (DOI: 10.1126/science.adh9351) nature.com/articles/s41392-0…

Janus-faced Mitofusin 2 (MFN2): mitochondria-endoplasmic reticulum shaping and tethering functions...

Signal Transduction and Targeted Therapy - Janus-faced Mitofusin 2 (MFN2): mitochondria-endoplasmic reticulum shaping and tethering functions unveiled

nature.com
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Motori Lab retweeted
CRC_1218@CRC_121821 Dec 2023
Pre-Christmas paper alert 🎄🚨 by #crc1218! @Mitochondrial dysfunction abrogates dietary lipid processing in enterocytes | Nature @AleXTrifunovic #ManolisPasparakis @moschandrea Huge congratulations to all authors!✨🎉 nature.com/articles/s41586-0… – at Cologne, Germany

Mitochondrial dysfunction abrogates dietary lipid processing in enterocytes

Nature - Mitochondria have a pivotal role in the transport of dietary lipids in enterocytes, a finding that might have relevance to understanding the aberrant gastrointestinal function in patients...

nature.com
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Replying to @ScienceAdvances
@ScienceAdvances published our paper in which we asked: "Where does all the sugar go in the brain?" ...it's less the size of the brain, than slow chemical signaling, 4 main findings below 🧵 doi.org/10.1126/sciadv.adi76… #ScienceAdvancesResearch funding: Starting Grant @ERC_Research
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PostDoc opportunity! We are looking for an enthusiastic #PostDoc to study how mitochondrial dysfunction contributes to the pathogenesis of neurodegenerative disease. Join my research group within @MolMet_KI @karolinskainst ki.varbi.com/en/what:job/job…

Postdoctoral studies in the field of mitochondrial dysfunction in neurodegeneration (scholarship)

Do you want to contribute to improving human health? The research at the Division of Molecular Metabolism aims at understanding the regulation of mitochondrial function and the role of mitochondrial d

ki.varbi.com
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Remember we were travelling a few weeks ago to look at possible destinations for our # glia2027. You guessed right, we were in #Italy, namely #Bologna + #Rimini. The decision has been made. #gliameeting goes to Bologna 🎉 We look forward to enjoying La Dolce Vita with you!
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Online now! A century of the Warburg effect dlvr.it/Sz8Chw

A century of the Warburg effect

Nature Metabolism - In 1923, Otto Warburg published his landmark study , in which he described his seminal observations related to metabolic shifts in cancer, often referred to as the Warburg...

nature.com
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Motori Lab retweeted
FrezzaLab@FrezzaLab25 Nov 2023
"Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative damage" nature.com/articles/s41593-0…
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How does mitochondria sense and control their glutathione levels? Our new work @ScienceMagazine by a fantastic student @YuyangLiu1996 describing a redox metabolite sensing mechanism for mitochondria. @RockefellerUniv @TheMarkFdn science.org/doi/10.1126/scie…

Autoregulatory control of mitochondrial glutathione homeostasis

Blockage of an inner mitochondrial membrane protease stabilizes a glutathione transporter, enabling autoregulatory homeostasis.

science.org
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IL-4 shapes microglia-dependent pruning of the cerebellum during postnatal development: Neuron cell.com/neuron/fulltext/S08…

IL-4 shapes microglia-dependent pruning of the cerebellum during postnatal development

Guedes and Ferreira et al. describe a critical window of cerebellar maturation during which a low Th2 environment is required for granule cell pruning by microglia. Early increase in IL-4 closes this...

cell.com
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Do you ❤️ the TCA cycle? (trick question). Our new review discusses the origins, discovery, and many functions of the mammalian TCA cycle. By @paigearnold2 @SKI_CellBiology out now in @jbiolchem jbc.org/article/S0021-9258(2…
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Motori Lab retweeted
CRC_1218@CRC_121822 Dec 2022
📣 SAVE THE DATE 📣07-10.03.2023 #CologneSpringMeeting2023 organized by @sfb_1403 and @CRC_1218 ▶️Open for Registration ▶️ colognespringmeeting2023.uni… @CECAD_ – at Cologne, Germany
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Fun during a joint Christmas breakfast with @LabMotori at @CECAD_!
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Motori Lab retweeted
Koen Kole@KoenKole9 Dec 2022
It is out! We found myelin-dependent clustering of mitochondria in parvalbumin interneurons but not L2/3 pyramidal neurons. Myelin sheaths also effectively attenuate mitochondrial calcium responses. Read all about it in the open access paper linked below! nature.com/articles/s41467-0…
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Motori Lab retweeted
Ons M'Saad@OnsMSaad13 Dec 2022
***See your cells without a microscope*** 👀 Introducing #UnclearingMicroscopy, where cells are expanded 8,000 volumetrically and opaqued with light-scattering molecules of high density to reveal cell microstructure with the naked eye bioRxiv: biorxiv.org/content/10.1101/…
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Dear all, a position for a graduate student is immediately available in my lab to work on mitochondria and primary progressive multiple sclerosis. See the attached flyer for details. Please feel free to pass this advertisement to anyone that could be interested. Many thanks
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